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    Acod1 aconitate decarboxylase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306127, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acod1provided by RGD
    Official Full Name
    aconitate decarboxylase 1provided by RGD
    Primary source
    RGD:1563454
    See related
    EnsemblRapid:ENSRNOG00000009919 AllianceGenome:RGD:1563454
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Irg1; RGD1563454
    Summary
    Predicted to enable aconitate decarboxylase activity and protein homodimerization activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; regulation of defense response; and regulation of gene expression. Predicted to act upstream of or within response to lipopolysaccharide. Predicted to be active in mitochondrion. Orthologous to human ACOD1 (aconitate decarboxylase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 5.2), Testes (RPKM 3.6) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acod1 in Genome Data Viewer
    Location:
    15q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (86286531..86295803)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (79871819..79881101)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (93612968..93622322)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 12 Neighboring gene uncharacterized LOC134482003 Neighboring gene uncharacterized LOC120097063 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC108352966

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The proinflammatory cytokine-induced IRG1 protein associates with mitochondria. Degrandi D, et al. J Interferon Cytokine Res, 2009 Jan. PMID 19014335
    2. Immune-responsive gene 1 is a novel target of progesterone receptor and plays a critical role during implantation in the mouse. Cheon YP, et al. Endocrinology, 2003 Dec. PMID 14500577
    3. Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Michelucci A, et al. Proc Natl Acad Sci U S A, 2013 May 7. PMID 23610393, Free PMC Article
    4. Cloning and analysis of gene regulation of a novel LPS-inducible cDNA. Lee CG, et al. Immunogenetics, 1995. PMID 7721348
    5. Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species. Li Y, et al. J Biol Chem, 2013 Jun 7. PMID 23609450, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aconitate decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aconitate decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to molecule of bacterial origin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to progesterone stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryo implantation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of toll-like receptor 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of antimicrobial humoral response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tolerance induction to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cis-aconitate decarboxylase
    Names
    immunoresponsive 1 homolog
    immunoresponsive gene 1
    NP_001100752.1
    XP_006252502.1
    XP_038949324.1
    XP_038949326.1
    XP_038949327.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107282.1 → NP_001100752.1  cis-aconitate decarboxylase

      See identical proteins and their annotated locations for NP_001100752.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473951
      UniProtKB/TrEMBL
      A6HU86, D3ZWM1
      Related
      ENSRNOP00000013182.4, ENSRNOT00000013182.8
      Conserved Domains (1) summary
      pfam03972
      Location:8 → 450
      MmgE_PrpD; MmgE/PrpD family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      86286531..86295803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093396.2 → XP_038949324.1  cis-aconitate decarboxylase isoform X1

      Conserved Domains (1) summary
      pfam03972
      Location:8 → 420
      MmgE_PrpD; MmgE/PrpD family

    2. XM_039093399.2 → XP_038949327.1  cis-aconitate decarboxylase isoform X3

      Conserved Domains (1) summary
      cl00912
      Location:2 → 232
      MmgE_PrpD; MmgE/PrpD family

    3. XM_006252440.5 → XP_006252502.1  cis-aconitate decarboxylase isoform X2

      Conserved Domains (1) summary
      pfam03972
      Location:1 → 359
      MmgE_PrpD; MmgE/PrpD family

    4. XM_039093398.2 → XP_038949326.1  cis-aconitate decarboxylase isoform X2

      Conserved Domains (1) summary
      pfam03972
      Location:1 → 359
      MmgE_PrpD; MmgE/PrpD family
    Nucleotide Protein Strain
    Heading Accession and Version

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