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    Septin12 septin 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363542, updated on 27-Dec-2024

    Summary

    Official Symbol
    Septin12provided by RGD
    Official Full Name
    septin 12provided by RGD
    Primary source
    RGD:1565511
    See related
    EnsemblRapid:ENSRNOG00000003137 AllianceGenome:RGD:1565511
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sept12
    Summary
    Predicted to enable several functions, including GTP binding activity; GTPase activity; and protein homodimerization activity. Predicted to be involved in cytoskeleton-dependent cytokinesis and protein localization. Predicted to be located in several cellular components, including midbody; perinuclear region of cytoplasm; and sperm annulus. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Human ortholog(s) of this gene implicated in spermatogenic failure 10. Orthologous to human SEPTIN12 (septin 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 168.0) See more
    Orthologs
    NEW
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    Genomic context

    See Septin12 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (11087354..11097036)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (10580900..10590582)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (10774702..10784276)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene rogdi atypical leucine zipper Neighboring gene small integral membrane protein 22 Neighboring gene dynein axonemal assembly factor 8 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of septin complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sperm annulus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100865.1NP_001094335.1  septin-12

      See identical proteins and their annotated locations for NP_001094335.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097401
      UniProtKB/Swiss-Prot
      Q4V8G5
      UniProtKB/TrEMBL
      A6K4P8
      Related
      ENSRNOP00000057921.1, ENSRNOT00000061208.4
      Conserved Domains (1) summary
      cd01850
      Location:45315
      CDC_Septin; CDC/Septin GTPase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      11087354..11097036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086448.2XP_038942376.1  septin-12 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A6R7, A6K4P9
      Related
      ENSRNOP00000088547.1, ENSRNOT00000111695.2
      Conserved Domains (1) summary
      cd01850
      Location:45272
      CDC_Septin; CDC/Septin GTPase family
    2. XM_039086446.2XP_038942374.1  septin-12 isoform X1

      Conserved Domains (1) summary
      cd01850
      Location:45272
      CDC_Septin; CDC/Septin GTPase family
    3. XM_039086447.2XP_038942375.1  septin-12 isoform X2

      Conserved Domains (1) summary
      cd01850
      Location:45272
      CDC_Septin; CDC/Septin GTPase family