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    Glis2 GLIS family zinc finger 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302946, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Glis2provided by RGD
    Official Full Name
    GLIS family zinc finger 2provided by RGD
    Primary source
    RGD:1309177
    See related
    EnsemblRapid:ENSRNOG00000004766 AllianceGenome:RGD:1309177
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in central nervous system development; negative regulation of smoothened signaling pathway; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including hematopoietic stem cell homeostasis; positive regulation of protein localization to nucleus; and regulation of transcription by RNA polymerase II. Predicted to be located in non-motile cilium and nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in nephronophthisis 7. Orthologous to human GLIS2 (GLIS family zinc finger 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 132.7), Lung (RPKM 73.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Glis2 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (11457594..11484948, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (10951157..10978524, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (11154459..11177063, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene coronin 7 Neighboring gene vasorin Neighboring gene uncharacterized LOC120095029 Neighboring gene presequence translocase associated motor 16 Neighboring gene uncharacterized LOC120095030 Neighboring gene transcription factor AP-4 Neighboring gene uncharacterized LOC134480651

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Up-regulation of Glis2 involves in neuronal apoptosis after intracerebral hemorrhage in adult rats. Ke K, et al. Cell Mol Neurobiol, 2015 Apr. PMID 25370802
    2. Kruppel-like zinc finger protein Glis2 is essential for the maintenance of normal renal functions. Kim YS, et al. Mol Cell Biol, 2008 Apr. PMID 18227149, Free PMC Article
    3. Identification of nuclear localization, DNA binding, and transactivating mechanisms of Kruppel-like zinc finger protein Gli-similar 2 (Glis2). Vasanth S, et al. J Biol Chem, 2011 Feb 11. PMID 21127075, Free PMC Article
    4. Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis. Attanasio M, et al. Nat Genet, 2007 Aug. PMID 17618285
    5. Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs. Li B, et al. Hum Mol Genet, 2011 Nov 1. PMID 21816948, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glis2 exerts pro-apoptotic functions in neurons following intracerebral hemorrhage.
      Title: Up-regulation of Glis2 involves in neuronal apoptosis after intracerebral hemorrhage in adult rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation involved in kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in non-motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein GLIS2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106978.1 → NP_001100448.1  zinc finger protein GLIS2

      See identical proteins and their annotated locations for NP_001100448.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474017
      UniProtKB/TrEMBL
      A6K4S5
      Related
      ENSRNOP00000099656.1, ENSRNOT00000153775.1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 327
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:213 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      11457594..11484948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085846.2 → XP_038941774.1  zinc finger protein GLIS2 isoform X1

      UniProtKB/TrEMBL
      D3ZIA9
      Conserved Domains (2) summary
      COG5048
      Location:234 → 328
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:213 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_039085847.2 → XP_038941775.1  zinc finger protein GLIS2 isoform X1

      UniProtKB/TrEMBL
      D3ZIA9
      Related
      ENSRNOP00000006680.5, ENSRNOT00000006680.7
      Conserved Domains (2) summary
      COG5048
      Location:234 → 328
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:213 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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