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    Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29747, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnmb1provided by RGD
    Official Full Name
    potassium calcium-activated channel subfamily M regulatory beta subunit 1provided by RGD
    Primary source
    RGD:2961
    See related
    EnsemblRapid:ENSRNOG00000005465 AllianceGenome:RGD:2961
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BKbeta; BKbeta1; slo-beta; slo-beta-1; k(VCA)beta-1
    Summary
    Enables potassium channel regulator activity. Involved in several processes, including cellular response to bile acid; cellular response to ethanol; and cellular response to hypoxia. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Used to study hypertension. Biomarker of hypertension and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human KCNMB1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 45.2), Kidney (RPKM 10.4) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kcnmb1 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (19062014..19119005)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (18557510..18614824)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (18910586..18922856)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel interacting protein 1 Neighboring gene large ribosomal subunit protein eL29-like Neighboring gene uncharacterized LOC120095245 Neighboring gene uncharacterized LOC134480773 Neighboring gene lymphocyte cytosolic protein 2 Neighboring gene similar to human chromosome 5 open reading frame 58

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-activated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    calcium-activated potassium channel subunit beta-1
    Names
    BK channel subunit beta-1
    calcium-activated potassium channel beta subunit
    calcium-activated potassium channel subunit beta
    calcium-activated potassium channel, subfamily M subunit beta-1
    charybdotoxin receptor subunit beta-1
    maxi K channel subunit beta-1
    potassium channel subfamily M regulatory beta subunit 1
    potassium large conductance calcium-activated channel, subfamily M, beta member 1
    slowpoke-beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019273.1NP_062146.1  calcium-activated potassium channel subunit beta-1

      See identical proteins and their annotated locations for NP_062146.1

      Status: PROVISIONAL

      Source sequence(s)
      AF020712
      UniProtKB/Swiss-Prot
      O35337, O88805, P97678, Q9ESK7, Q9QWI7
      UniProtKB/TrEMBL
      A6HDH5, B5U130
      Related
      ENSRNOP00000103628.1, ENSRNOT00000159821.1
      Conserved Domains (1) summary
      pfam03185
      Location:7190
      CaKB; Calcium-activated potassium channel, beta subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      19062014..19119005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085796.2XP_038941724.1  calcium-activated potassium channel subunit beta-1 isoform X2

      Conserved Domains (1) summary
      pfam03185
      Location:7102
      CaKB; Calcium-activated potassium channel, beta subunit
    2. XM_039085797.2XP_038941725.1  calcium-activated potassium channel subunit beta-1 isoform X3

      UniProtKB/TrEMBL
      A6HDH4
      Related
      ENSRNOP00000071161.2, ENSRNOT00000090659.3
      Conserved Domains (1) summary
      pfam03185
      Location:7126
      CaKB; Calcium-activated potassium channel, beta subunit
    3. XM_006246089.5XP_006246151.1  calcium-activated potassium channel subunit beta-1 isoform X1

      See identical proteins and their annotated locations for XP_006246151.1

      UniProtKB/Swiss-Prot
      O35337, O88805, P97678, Q9ESK7, Q9QWI7
      UniProtKB/TrEMBL
      A6HDH5, B5U130
      Conserved Domains (1) summary
      pfam03185
      Location:7190
      CaKB; Calcium-activated potassium channel, beta subunit
    4. XM_063268844.1XP_063124914.1  calcium-activated potassium channel subunit beta-1 isoform X3

      UniProtKB/TrEMBL
      A6HDH4