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    Brsk2 BR serine/threonine kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293631, updated on 4-Jan-2025

    Summary

    Symbol
    Brsk2provided by RGD
    Full Name
    BR serine/threonine kinase 2provided by RGD
    Primary source
    RGD:1566256
    See related
    EnsemblRapid:ENSRNOG00000020021 AllianceGenome:RGD:1566256
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including G2/M transition of mitotic cell cycle; cytoskeleton organization; and intracellular signal transduction. Predicted to act upstream of or within neuron projection morphogenesis and peptidyl-serine phosphorylation. Located in distal axon. Orthologous to human BRSK2 (BR serine/threonine kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Brain (RPKM 120.1) and Spleen (RPKM 6.7) See more
    Orthologs
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    Genomic context

    See Brsk2 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (206465040..206518156)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (197035505..197088624)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214918757..214940883)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene mucin 5B, oligomeric mucus/gel-forming Neighboring gene toll interacting protein Neighboring gene uncharacterized LOC134485203 Neighboring gene MOB kinase activator 2 Neighboring gene dual specificity phosphatase 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 39
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables ATP binding  
    enables ATPase binding  
    enables ATPase binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables metal ion binding  
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables ribosomal protein S6 kinase activity  
    enables tau-protein kinase activity  
    enables tau-protein kinase activity  
    enables tau-protein kinase activity  
    enables tau-protein kinase activity  
    Items 1 - 25 of 39
    Items 1 - 25 of 40
    Process Evidence Code Pubs
    involved_in DNA damage response PubMed 
    involved_in ERAD pathway  
    involved_in ERAD pathway  
    involved_in G2/M transition of mitotic cell cycle  
    involved_in G2/M transition of mitotic cell cycle  
    involved_in G2/M transition of mitotic cell cycle  
    involved_in actin cytoskeleton organization  
    involved_in actin cytoskeleton organization  
    involved_in axonogenesis  
    involved_in axonogenesis  
    involved_in axonogenesis  
    involved_in axonogenesis  
    involved_in cell division  
    involved_in chromatin remodeling  
    involved_in establishment of cell polarity  
    involved_in establishment of cell polarity  
    acts_upstream_of_or_within establishment of cell polarity  
    involved_in establishment of cell polarity  
    involved_in establishment of cell polarity  
    involved_in exocytosis  
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  
    involved_in microtubule cytoskeleton organization involved in establishment of planar polarity  
    involved_in microtubule cytoskeleton organization involved in establishment of planar polarity  
    involved_in mitotic G2 DNA damage checkpoint signaling PubMed 
    involved_in mitotic cell cycle checkpoint signaling  
    involved_in nervous system development  
    acts_upstream_of_or_within neuron differentiation  
    involved_in neuron differentiation  
    acts_upstream_of_or_within neuron projection morphogenesis  
    acts_upstream_of_or_within peptidyl-serine phosphorylation  
    involved_in protein phosphorylation  
    involved_in protein phosphorylation PubMed 
    involved_in regulation of axonogenesis  
    involved_in regulation of axonogenesis  
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus  
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus  
    involved_in regulation of neuron projection development  
    involved_in response to UV PubMed 
    NOT involved_in response to ionizing radiation PubMed 
    Items 1 - 25 of 40
    Component Evidence Code Pubs
    is_active_in centrosome  
    located_in centrosome  
    located_in centrosome  
    located_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in distal axon PubMed 
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in nucleus PubMed 
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    serine/threonine-protein kinase BRSK2
    Names
    BR serine/threonine-protein kinase 2
    brain serine/threonine kinase 2
    brain-specific serine/threonine-protein kinase 2
    serine/threonine-protein kinase BRSK2-like
    serine/threonine-protein kinase SAD-A
    NP_001406495.1
    XP_038957200.1
    XP_038957201.1
    XP_038957202.1
    XP_038957203.1
    XP_038957204.1
    XP_038957206.1
    XP_038957207.1
    XP_038957208.1
    XP_038957209.1
    XP_038957210.1
    XP_038957212.1
    XP_038957213.1
    XP_038957214.1
    XP_038957215.1
    XP_063142736.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419566.1NP_001406495.1  serine/threonine-protein kinase BRSK2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Related
      ENSRNOP00000097899.2, ENSRNOT00000116048.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      206465040..206518156
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101272.2XP_038957200.1  serine/threonine-protein kinase BRSK2 isoform X1

      Conserved Domains (2) summary
      cd14340
      Location:298351
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:18271
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    2. XM_039101273.2XP_038957201.1  serine/threonine-protein kinase BRSK2 isoform X2

      Related
      ENSRNOP00000078625.2, ENSRNOT00000113716.2
      Conserved Domains (2) summary
      cd14340
      Location:298351
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:18271
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    3. XM_039101274.2XP_038957202.1  serine/threonine-protein kinase BRSK2 isoform X3

      Conserved Domains (2) summary
      cd14340
      Location:298351
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:18271
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    4. XM_039101275.2XP_038957203.1  serine/threonine-protein kinase BRSK2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GM96
      Conserved Domains (2) summary
      cd14340
      Location:298351
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:18271
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    5. XM_039101281.2XP_038957209.1  serine/threonine-protein kinase BRSK2 isoform X7

      Conserved Domains (2) summary
      cd14340
      Location:298351
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:18271
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    6. XM_039101276.2XP_038957204.1  serine/threonine-protein kinase BRSK2 isoform X5

      Conserved Domains (2) summary
      cd14340
      Location:298351
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:18271
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    7. XM_039101279.2XP_038957207.1  serine/threonine-protein kinase BRSK2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6ABA6
      Conserved Domains (2) summary
      cd14340
      Location:298351
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:18271
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    8. XM_039101284.2XP_038957212.1  serine/threonine-protein kinase BRSK2 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZQ20
      Related
      ENSRNOP00000080546.1, ENSRNOT00000117225.2
      Conserved Domains (2) summary
      cd14340
      Location:298351
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:18271
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    9. XM_039101285.2XP_038957213.1  serine/threonine-protein kinase BRSK2 isoform X11

      Conserved Domains (2) summary
      cd14340
      Location:298351
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:18271
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    10. XM_039101278.2XP_038957206.1  serine/threonine-protein kinase BRSK2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6ABA6
      Conserved Domains (2) summary
      cd14340
      Location:298351
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:18271
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    11. XM_039101280.2XP_038957208.1  serine/threonine-protein kinase BRSK2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6ABA6
      Conserved Domains (2) summary
      cd14340
      Location:298351
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:18271
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    12. XM_063286666.1XP_063142736.1  serine/threonine-protein kinase BRSK2 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZLC7
      Related
      ENSRNOP00000090176.2, ENSRNOT00000113212.2
    13. XM_039101286.2XP_038957214.1  serine/threonine-protein kinase BRSK2 isoform X12

      Conserved Domains (2) summary
      cd14340
      Location:298351
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:18271
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    14. XM_039101282.2XP_038957210.1  serine/threonine-protein kinase BRSK2 isoform X8

      Conserved Domains (2) summary
      cd14340
      Location:217270
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cl21453
      Location:12190
      PKc_like; Protein Kinases, catalytic domain
    15. XM_039101287.2XP_038957215.1  serine/threonine-protein kinase BRSK2 isoform X13

      Conserved Domains (1) summary
      cd14340
      Location:3386
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

    RNA

    1. XR_005499534.2 RNA Sequence

    2. XR_005499535.2 RNA Sequence

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