Ryr1 ryanodine receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ryr1provided by RGD
Official Full Name: ryanodine receptor 1provided by RGD
Primary source: RGD:1586637
See related: EnsemblRapid:ENSRNOG00000020557 AllianceGenome:RGD:1586637
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RYR-1; Ryr1l
Summary: Enables ryanodine-sensitive calcium-release channel activity. Involved in several processes, including cellular response to ATP; negative regulation of transforming growth factor beta receptor signaling pathway; and release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Located in several cellular components, including sarcolemma; sarcomere; and sarcoplasmic reticulum. Is extrinsic component of cytoplasmic side of plasma membrane. Used to study myocardial infarction. Biomarker of osteochondrodysplasia and pulmonary hypertension. Human ortholog(s) of this gene implicated in congestive heart failure (multiple); intracranial vasospasm; and muscle tissue disease (multiple). Orthologous to human RYR1 (ryanodine receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 2762.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 106

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (93420078..93551305, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (84292578..84423824, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (87959596..88066252, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Redox modification of ryanodine receptor contributes to impaired Ca(2+) homeostasis and exacerbates muscle atrophy under high altitude.
Title: Redox modification of ryanodine receptor contributes to impaired Ca(2+) homeostasis and exacerbates muscle atrophy under high altitude.
Ryanodine receptor 1 mediated dexamethasone-induced chondrodysplasia in fetal rats.
Title: Ryanodine receptor 1 mediated dexamethasone-induced chondrodysplasia in fetal rats.
ERalpha has a profound regulatory role in ryanodine receptor-dependent transition to chronic pain
Title: Marked Sexual Dimorphism in the Role of the Ryanodine Receptor in a Model of Pain Chronification in the Rat.
Septic diaphragm contractility and expression of RyR1 and DHPRalpha1s are significantly decreased in a sepsis model compared with controls.
Title: Decreased intracellular [Ca(2+) ] coincides with reduced expression of Dhprα1s, RyR1, and diaphragmatic dysfunction in a rat model of sepsis.
these results suggest that RyR1 expression and voltage-dependent Ca2+ channels activity are the focal points of the regulation of Ca2+ signals activated by vasoconstriction in rat cerebral arteries with an increase of the voltage-dependent Ca2+ influx.
Title: Up-regulation of ryanodine receptor expression increases the calcium-induced calcium release and spontaneous calcium signals in cerebral arteries from hindlimb unloaded rats.
RyR sensitization by PCB 95 activates the CREB-dependent signaling pathway to trigger dendritic spine formation and synaptogenesis.
Title: The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation.
These results indicate that RyR1 possesses a mitochondrial targeting/retention signal and modulates mitochondrial morphology and Ca(2+)-induced ATP production in cardiac H9c2 myoblasts.
Title: Overexpression of ryanodine receptor type 1 enhances mitochondrial fragmentation and Ca2+-induced ATP production in cardiac H9c2 myoblasts.
The expression levels of dihydropyridine alpha1s and RyR1 receptors (the isoforms of skeletal muscles) are significantly lower in the diaphragm of septic rats than in control rats.
Title: Reduced DHPRα1S and RyR1 expression levels are associated with diaphragm contractile dysfunction during sepsis.
RyR1 expression was elevated in the gracilis muscle of rats with pressure ulcer in the early stage. Activity of total ATPase was positively correlated with the RyR1 mRNA expression level.
Title: [Activity of adenosine triphosphatase and the expression of ryanodine receptor 1 mRNA in local tissue of pressure ulcer at early stage in gracilis of rats].
a novel 225 pS channel is the native mitochondrial ryanodine receptor channel activity in heart mitoplasts with biophysical and pharmacological properties that distinguish it from previously identified mitochondrial ion channels
Title: Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU028111 (e-PCR)
- UniSTS:112648

AU049008 (e-PCR)
- UniSTS:145456

RH133862 (e-PCR)
- UniSTS:217145

RH130025 (e-PCR)
- UniSTS:213313

AI528790 (e-PCR)
- UniSTS:185702

AW534727 (e-PCR)
- UniSTS:260812

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-induced calcium release activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ryanodine-sensitive calcium-release channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ryanodine-sensitive calcium-release channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ryanodine-sensitive calcium-release channel activity	IEA Inferred from Electronic Annotation more info
enables ryanodine-sensitive calcium-release channel activity	ISO Inferred from Sequence Orthology more info
enables ryanodine-sensitive calcium-release channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ATP	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to caffeine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to caffeine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to caffeine	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in muscle contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ossification involved in bone maturation	ISO Inferred from Sequence Orthology more info
involved_in ossification involved in bone maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in outflow tract morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to caffeine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to caloric restriction	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in sarcoplasmic reticulum calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in skeletal muscle contraction	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal muscle fiber development	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle fiber development	ISS Inferred from Sequence or Structural Similarity more info
involved_in skin development	ISO Inferred from Sequence Orthology more info
involved_in skin development	ISS Inferred from Sequence or Structural Similarity more info
involved_in striated muscle contraction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in I band	IEA Inferred from Electronic Annotation more info
located_in I band	ISO Inferred from Sequence Orthology more info
located_in T-tubule	ISO Inferred from Sequence Orthology more info
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
part_of calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extrinsic component of cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of junctional membrane complex	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in organelle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of ryanodine receptor complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcomere	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in sarcoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in smooth endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in smooth endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in terminal cisterna	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ryanodine receptor 1

Names: ryanodine receptor 1 (skeletal); ryanodine receptor 1, skeletal muscle; ryanodine receptor 1-like, skeletal muscle; skeletal muscle calcium release channel; skeletal muscle ryanodine receptor; skeletal muscle-type ryanodine receptor; type 1 ryanodine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419537.1 → NP_001406466.1 ryanodine receptor 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0G2K5J1, V9GZ83

Related

ENSRNOP00000073446.2, ENSRNOT00000079473.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

93420078..93551305 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039100854.2 → XP_038956782.1 ryanodine receptor 1 isoform X3

UniProtKB/TrEMBL

A0A0G2K5J1

Related

ENSRNOP00000027893.8, ENSRNOT00000027893.8

Conserved Domains (10) summary

cd12877
Location:644 → 795

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1074 → 1206

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1420 → 1568

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4751 → 4935

Ion_trans; Ion transport protein

pfam01365
Location:445 → 638

RYDR_ITPR; RIH domain

pfam02026
Location:852 → 942

RyR; RyR domain

pfam02815
Location:213 → 391

MIR; MIR domain

pfam06459
Location:4369 → 4657

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3869 → 3985

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:12 → 211

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_039100852.2 → XP_038956780.1 ryanodine receptor 1 isoform X1

UniProtKB/TrEMBL

A0A0G2K5J1

Conserved Domains (10) summary

cd12877
Location:644 → 795

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1074 → 1206

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1420 → 1568

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4757 → 4941

Ion_trans; Ion transport protein

pfam01365
Location:445 → 638

RYDR_ITPR; RIH domain

pfam02026
Location:852 → 942

RyR; RyR domain

pfam02815
Location:213 → 391

MIR; MIR domain

pfam06459
Location:4375 → 4663

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3875 → 3991

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:12 → 211

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_039100853.2 → XP_038956781.1 ryanodine receptor 1 isoform X2

UniProtKB/TrEMBL

A0A0G2K5J1

Conserved Domains (10) summary

cd12877
Location:644 → 795

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1074 → 1206

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1420 → 1568

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4756 → 4940

Ion_trans; Ion transport protein

pfam01365
Location:445 → 638

RYDR_ITPR; RIH domain

pfam02026
Location:852 → 942

RyR; RyR domain

pfam02815
Location:213 → 391

MIR; MIR domain

pfam06459
Location:4374 → 4662

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3874 → 3990

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:12 → 211

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor