Fuz fuzzy planar cell polarity protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fuzprovided by RGD
Official Full Name: fuzzy planar cell polarity proteinprovided by RGD
Primary source: RGD:1310608
See related: EnsemblRapid:ENSRNOG00000053084 AllianceGenome:RGD:1310608
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310608
Summary: Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including embryonic morphogenesis; non-motile cilium assembly; and regulation of signal transduction. Predicted to act upstream of or within several processes, including circulatory system development; embryonic morphogenesis; and regionalization. Predicted to be located in cell projection; cytoplasm; and cytoskeleton. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human FUZ (fuzzy planar cell polarity protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 59.8), Brain (RPKM 49.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (104515782..104524591)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (95379542..95384532)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (100891832..100896811)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AW530045 (e-PCR)
- UniSTS:244502

Ap2a1 (e-PCR), detects polymorphism
- UniSTS:141096

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within aorta development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac septum development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within coronary vasculature development	ISO Inferred from Sequence Orthology more info
involved_in embryonic body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic body morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic neurocranium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal system morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of planar polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of planar polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in hair follicle development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within larynx morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neural crest formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neural crest formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in neural tube closure	ISS Inferred from Sequence or Structural Similarity more info
involved_in non-motile cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in non-motile cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of protein processing	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of smoothened signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spinal cord development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spinal cord dorsal/ventral patterning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tongue morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein fuzzy homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037646.2 → NP_001032735.1 protein fuzzy homolog isoform 2

See identical proteins and their annotated locations for NP_001032735.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I5XV94

Related

ENSRNOP00000074982.1, ENSRNOT00000086890.3
NM_001399381.1 → NP_001386310.1 protein fuzzy homolog isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q3B756

UniProtKB/TrEMBL

A0A8I5XV94, A6JAU2

Related

ENSRNOP00000070688.1, ENSRNOT00000083336.3

Conserved Domains (1) summary

cd21091
Location:12 → 413

Fuzzy; protein fuzzy and homologs
NM_001399382.1 → NP_001386311.1 protein fuzzy homolog isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

Conserved Domains (1) summary

cl40581
Location:12 → 322

Fuzzy; protein fuzzy and homologs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

104515782..104524591

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229060.5 → XP_006229122.1 protein fuzzy homolog isoform X2

UniProtKB/TrEMBL

A0A8I5XV94, A0A8I6ABP8

Related

ENSRNOP00000091471.1, ENSRNOT00000114637.2
XM_039112059.2 → XP_038967987.1 protein fuzzy homolog isoform X7

Conserved Domains (1) summary

cl40581
Location:12 → 263

Fuzzy; protein fuzzy and homologs
XM_063261942.1 → XP_063118012.1 protein fuzzy homolog isoform X4
XM_063261966.1 → XP_063118036.1 protein fuzzy homolog isoform X9
XM_063261949.1 → XP_063118019.1 protein fuzzy homolog isoform X7
XM_039112029.2 → XP_038967957.1 protein fuzzy homolog isoform X1

UniProtKB/TrEMBL

A0A8I5XV94

Related

ENSRNOP00000112429.1, ENSRNOT00000152626.1

Conserved Domains (1) summary

cl40581
Location:12 → 390

Fuzzy; protein fuzzy and homologs
XM_039112048.2 → XP_038967976.1 protein fuzzy homolog isoform X6

UniProtKB/TrEMBL

A0A8I5XV94

Conserved Domains (1) summary

cl40581
Location:12 → 324

Fuzzy; protein fuzzy and homologs
XM_063261955.1 → XP_063118025.1 protein fuzzy homolog isoform X8
XM_006229061.5 → XP_006229123.1 protein fuzzy homolog isoform X3

UniProtKB/TrEMBL

A0A8I5XV94
XM_039112046.2 → XP_038967974.1 protein fuzzy homolog isoform X5

UniProtKB/TrEMBL

A0A8I5XV94

Conserved Domains (1) summary

cl40581
Location:20 → 332

Fuzzy; protein fuzzy and homologs
XM_039112064.2 → XP_038967992.1 protein fuzzy homolog isoform X10

Conserved Domains (1) summary

cl40581
Location:1 → 251

Fuzzy; protein fuzzy and homologs