U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Coq8b coenzyme Q8B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308453, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Coq8bprovided by RGD
    Official Full Name
    coenzyme Q8Bprovided by RGD
    Primary source
    RGD:1311356
    See related
    EnsemblRapid:ENSRNOG00000020848 AllianceGenome:RGD:1311356
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Adck4
    Summary
    Predicted to enable ATP binding activity. Predicted to be involved in cerebellar Purkinje cell layer morphogenesis and ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in nephrotic syndrome type 9. Orthologous to human COQ8B (coenzyme Q8B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 111.6), Testes (RPKM 77.2) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Coq8b in Genome Data Viewer
    Location:
    1q21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (91653241..91676822)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (82525578..82549182)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (84043487..84067066)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein polypeptide A Neighboring gene actin maturation protease Neighboring gene inositol-trisphosphate 3-kinase C Neighboring gene NUMB-like, endocytic adaptor protein Neighboring gene ribosomal protein L14, pseudogene 3 Neighboring gene uncharacterized LOC120099779 Neighboring gene small nuclear ribonucleoprotein G-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity. Stefely JA, et al. Mol Cell, 2016 Aug 18. PMID 27499294, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cerebellar Purkinje cell layer morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cerebellar Purkinje cell layer morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquinone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    atypical kinase COQ8B, mitochondrial
    Names
    aarF domain containing kinase 4
    aarF domain-containing protein kinase 4
    coenzyme Q protein 8B

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012065.1 → NP_001012065.1  atypical kinase COQ8B, mitochondrial

      See identical proteins and their annotated locations for NP_001012065.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079227
      UniProtKB/Swiss-Prot
      Q6AY19
      UniProtKB/TrEMBL
      A0A8I6AH42
      Related
      ENSRNOP00000028290.6, ENSRNOT00000028290.8
      Conserved Domains (1) summary
      cd13970
      Location:171 → 420
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      91653241..91676822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261398.1 → XP_063117468.1  atypical kinase COQ8B, mitochondrial isoform X3

    2. XM_017589119.3 → XP_017444608.1  atypical kinase COQ8B, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q6AY19
      UniProtKB/TrEMBL
      A0A8I6AH42
      Conserved Domains (1) summary
      cd13970
      Location:171 → 420
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

    3. XM_039111525.2 → XP_038967453.1  atypical kinase COQ8B, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:171 → 294
      PKc_like; Protein Kinases, catalytic domain

    4. XM_039111513.2 → XP_038967441.1  atypical kinase COQ8B, mitochondrial isoform X2

      Conserved Domains (1) summary
      cd13970
      Location:17 → 266
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

    5. XM_063261396.1 → XP_063117466.1  atypical kinase COQ8B, mitochondrial isoform X2

    6. XM_063261394.1 → XP_063117464.1  atypical kinase COQ8B, mitochondrial isoform X2

    RNA

    1. XR_005505196.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY19.1 GenPept UniProtKB/Swiss-Prot:Q6AY19

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools