Myo7a myosin VIIA [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myo7aprovided by RGD
Official Full Name: myosin VIIAprovided by RGD
Primary source: RGD:628830
See related: EnsemblRapid:ENSRNOG00000013641 AllianceGenome:RGD:628830
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including adenyl ribonucleotide binding activity; calmodulin binding activity; and identical protein binding activity. Involved in actin filament-based movement. Located in upper tip-link density. Part of myosin VII complex. Used to study Usher syndrome. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Usher syndrome (multiple); auditory system disease (multiple); and congenital nystagmus. Orthologous to human MYO7A (myosin VIIA). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 123.9), Kidney (RPKM 118.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 52

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (161755110..161825397, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (152342611..152414171, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (163001313..163071545, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

crucial to support cellular transport and adhesion during spermatogenesis
Title: Myosin VIIa Supports Spermatid/Organelle Transport and Cell Adhesion During Spermatogenesis in the Rat Testis.
Data indicate that CNGA3 interacts with cadherin 23 and with cadherin 23 binding partner, myosin VIIa.
Title: Cyclic nucleotide-gated channel α-3 (CNGA3) interacts with stereocilia tip-link cadherin 23 + exon 68 or alternatively with myosin VIIa, two proteins required for hair cell mechanotransduction.
Myo7a is the candidate gene for the human Usher syndromes model.
Title: Identification of a rat model for usher syndrome type 1B by N-ethyl-N-nitrosourea mutagenesis-driven forward genetics.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Myo7a (e-PCR), detects polymorphism
- UniSTS:532116

RH136948 (e-PCR)
- UniSTS:219037

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal motor activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IDA Inferred from Direct Assay more info	PubMed
enables microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables spectrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament-based movement	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within auditory receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell projection organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cochlea development	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in equilibrioception	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear auditory receptor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear receptor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in lysosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mechanoreceptor differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagolysosome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pigment granule localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pigment granule transport	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISO Inferred from Sequence Orthology more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of light stimulus	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of light stimulus	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info
involved_in visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in melanosome	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin VII complex	IDA Inferred from Direct Assay more info	PubMed
part_of myosin complex	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor connecting cilium	ISO Inferred from Sequence Orthology more info
NOT located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
NOT located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
is_active_in stereocilium	ISO Inferred from Sequence Orthology more info
located_in stereocilium	ISO Inferred from Sequence Orthology more info
located_in stereocilium base	ISO Inferred from Sequence Orthology more info
NOT located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in upper tip-link density	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: unconventional myosin-VIIa

Names: myosin VIIA (Usher syndrome 1B (autosomal recessive, severe)); myosin-VIIa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001414743.1 → NP_001401672.1 unconventional myosin-VIIa isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I5ZWB0, A6I6C4

Related

ENSRNOP00000083122.1, ENSRNOT00000103282.2
NM_153473.2 → NP_703203.1 unconventional myosin-VIIa isoform 2

See identical proteins and their annotated locations for NP_703203.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6I6C4, D4AB24, Q8CJE3

Conserved Domains (13) summary

smart00015
Location:766 → 787

IQ; Calmodulin-binding motif

cd11881
Location:1567 → 1631

SH3_MYO7A; Src Homology 3 domain of Myosin VIIa and similar proteins

smart00139
Location:1709 → 1858

MyTH4; Domain in Myosin and Kinesin Tails

smart00242
Location:60 → 741

MYSc; Myosin. Large ATPases

smart00295
Location:1865 → 2077

B41; Band 4.1 homologues

cd13198
Location:1468 → 1566

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:2073 → 2168

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd14473
Location:1363 → 1463

FERM_B-lobe; FERM domain B-lobe

cd01381
Location:79 → 729

MYSc_Myo7; class VII myosin, motor domain

pfam00373
Location:1975 → 2077

FERM_M; FERM central domain

pfam05672
Location:857 → 935

MAP7; MAP7 (E-MAP-115) family

pfam08597
Location:875 → 930

eIF3_subunit; Translation initiation factor eIF3 subunit

pfam09379
Location:1262 → 1301

FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

161755110..161825397 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229744.5 → XP_006229806.1 unconventional myosin-VIIa isoform X2

UniProtKB/TrEMBL

A0A8J8XYU9, A6I6C5

Related

ENSRNOP00000019053.7, ENSRNOT00000019053.8

Conserved Domains (13) summary

smart00015
Location:766 → 787

IQ; Calmodulin-binding motif

cd11881
Location:1605 → 1669

SH3_MYO7A; Src Homology 3 domain of Myosin VIIa and similar proteins

smart00139
Location:1747 → 1896

MyTH4; Domain in Myosin and Kinesin Tails

smart00242
Location:60 → 741

MYSc; Myosin. Large ATPases

smart00295
Location:1903 → 2115

B41; Band 4.1 homologues

cd13198
Location:1468 → 1604

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:2111 → 2206

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd14473
Location:1363 → 1463

FERM_B-lobe; FERM domain B-lobe

cd01381
Location:79 → 729

MYSc_Myo7; class VII myosin, motor domain

pfam00373
Location:2013 → 2115

FERM_M; FERM central domain

pfam05672
Location:857 → 935

MAP7; MAP7 (E-MAP-115) family

pfam08597
Location:875 → 930

eIF3_subunit; Translation initiation factor eIF3 subunit

pfam09379
Location:1262 → 1301

FERM_N; FERM N-terminal domain
XM_006229742.5 → XP_006229804.1 unconventional myosin-VIIa isoform X1

UniProtKB/TrEMBL

A6I6C5

Conserved Domains (13) summary

smart00015
Location:827 → 848

IQ; Calmodulin-binding motif

cd11881
Location:1666 → 1730

SH3_MYO7A; Src Homology 3 domain of Myosin VIIa and similar proteins

smart00139
Location:1808 → 1957

MyTH4; Domain in Myosin and Kinesin Tails

smart00242
Location:121 → 802

MYSc; Myosin. Large ATPases

smart00295
Location:1964 → 2176

B41; Band 4.1 homologues

cd13198
Location:1529 → 1665

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:2172 → 2267

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd14473
Location:1424 → 1524

FERM_B-lobe; FERM domain B-lobe

cd01381
Location:140 → 790

MYSc_Myo7; class VII myosin, motor domain

pfam00373
Location:2074 → 2176

FERM_M; FERM central domain

pfam05672
Location:918 → 996

MAP7; MAP7 (E-MAP-115) family

pfam08597
Location:936 → 991

eIF3_subunit; Translation initiation factor eIF3 subunit

pfam09379
Location:1323 → 1362

FERM_N; FERM N-terminal domain
XM_039102474.2 → XP_038958402.1 unconventional myosin-VIIa isoform X3

UniProtKB/TrEMBL

A6I6C5

Conserved Domains (10) summary

smart00015
Location:755 → 776

IQ; Calmodulin-binding motif

cd11881
Location:1594 → 1658

SH3_MYO7A; Src Homology 3 domain of Myosin VIIa and similar proteins

smart00139
Location:1736 → 1885

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1892 → 2104

B41; Band 4.1 homologues

cd13198
Location:1457 → 1593

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:2100 → 2195

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd01381
Location:68 → 718

MYSc_Myo7; class VII myosin, motor domain

cd17092
Location:1246 → 1344

FERM1_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 1, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

cd17093
Location:1890 → 1987

FERM2_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 2, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

pfam15346
Location:832 → 924

ARGLU; Arginine and glutamate-rich 1
XM_039102487.2 → XP_038958415.1 unconventional myosin-VIIa isoform X5

Conserved Domains (9) summary

cd11881
Location:994 → 1058

SH3_MYO7A; Src Homology 3 domain of Myosin VIIa and similar proteins

smart00139
Location:1136 → 1285

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1292 → 1504

B41; Band 4.1 homologues

COG5022
Location:33 → 335

COG5022; Myosin heavy chain [General function prediction only]

cd13198
Location:857 → 993

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:1500 → 1595

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd17092
Location:646 → 744

FERM1_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 1, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

cd17093
Location:1290 → 1387

FERM2_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 2, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

cl22853
Location:33 → 118

Motor_domain; Myosin and Kinesin motor domain
XM_039102483.2 → XP_038958411.1 unconventional myosin-VIIa isoform X4

Conserved Domains (9) summary

cd11881
Location:1008 → 1072

SH3_MYO7A; Src Homology 3 domain of Myosin VIIa and similar proteins

smart00139
Location:1150 → 1299

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1306 → 1518

B41; Band 4.1 homologues

COG5022
Location:47 → 349

COG5022; Myosin heavy chain [General function prediction only]

cd13198
Location:871 → 1007

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:1514 → 1609

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd17092
Location:660 → 758

FERM1_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 1, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

cd17093
Location:1304 → 1401

FERM2_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 2, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

cl22853
Location:47 → 132

Motor_domain; Myosin and Kinesin motor domain