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    Napa NSF attachment protein alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140673, updated on 9-Dec-2024

    Summary

    Official Symbol
    Napaprovided by RGD
    Official Full Name
    NSF attachment protein alphaprovided by RGD
    Primary source
    RGD:620855
    See related
    EnsemblRapid:ENSRNOG00000001494 AllianceGenome:RGD:620855
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    alpha-SNAP
    Summary
    Enables syntaxin binding activity. Involved in positive regulation of ATP-dependent activity and protein-containing complex disassembly. Located in terminal bouton. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex. Is active in neuromuscular junction; postsynapse; and presynaptic active zone membrane. Orthologous to human NAPA (NSF attachment protein alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 379.9), Muscle (RPKM 299.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Napa in Genome Data Viewer
    Location:
    1q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (85915088..85934054)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (76787036..76805869)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (77994227..78012846)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691043 Neighboring gene BRD4 interacting chromatin remodeling complex associated protein Neighboring gene zinc finger protein 541 Neighboring gene kaptin (actin binding protein) Neighboring gene solute carrier family 8 member A2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNARE binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables SNARE binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables soluble NSF attachment protein activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables syntaxin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in SNARE complex disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in SNARE complex disassembly IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within SNARE complex disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apical protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within apical protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane fusion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ATP-dependent activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein-containing complex disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of synaptic vesicle priming IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of synaptic vesicle priming ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic vesicle priming ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic vesicle priming IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic vesicle priming ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in terminal bouton HDA PubMed 

    General protein information

    Preferred Names
    alpha-soluble NSF attachment protein
    Names
    N-ethylmaleimide sensitive fusion protein attachment protein alpha
    N-ethylmaleimide-sensitive factor attachment protein, alpha
    SNAP-alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080585.2NP_542152.1  alpha-soluble NSF attachment protein

      See identical proteins and their annotated locations for NP_542152.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P54921
      UniProtKB/TrEMBL
      A0A8L2PZF0, A6J895
      Related
      ENSRNOP00000081324.2, ENSRNOT00000103865.2
      Conserved Domains (1) summary
      pfam14938
      Location:19287
      SNAP; Soluble NSF attachment protein, SNAP

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      85915088..85934054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081759.2XP_038937687.1  alpha-soluble NSF attachment protein isoform X1

      UniProtKB/TrEMBL
      A0A8L2PZF0
      Related
      ENSRNOP00000002044.5, ENSRNOT00000002044.8
      Conserved Domains (1) summary
      pfam14938
      Location:19279
      SNAP; Soluble NSF attachment protein, SNAP
    2. XM_063270674.1XP_063126744.1  alpha-soluble NSF attachment protein isoform X3

    3. XM_039081799.2XP_038937727.1  alpha-soluble NSF attachment protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQH1
      Conserved Domains (1) summary
      pfam14938
      Location:2237
      SNAP; Soluble NSF attachment protein, SNAP
    4. XM_063270700.1XP_063126770.1  alpha-soluble NSF attachment protein isoform X3