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    KDM5A lysine demethylase 5A [ Canis lupus familiaris (dog) ]

    Gene ID: 477727, updated on 17-Aug-2024

    Summary

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    Official Symbol
    KDM5Aprovided by VGNC
    Official Full Name
    lysine demethylase 5Aprovided by VGNC
    Primary source
    VGNC:VGNC:42327
    See related
    Ensembl:ENSCAFG00845027343
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    JARID1A
    Orthologs
    human mouse all
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    Genomic context

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    See KDM5A in Genome Data Viewer
    Location:
    chromosome: 27
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (42718407..42806253, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (4236467..4324130)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (3597143..3683827)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (42663789..42745548, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (42630772..42717451, complement)

    Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 12 Neighboring gene solute carrier family 6 member 13 Neighboring gene uncharacterized LOC102151557 Neighboring gene ran guanine nucleotide release factor-like Neighboring gene coiled-coil domain containing 77 Neighboring gene beta-1,4-N-acetyl-galactosaminyltransferase 3 Neighboring gene uncharacterized LOC111092728

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone demethylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lysine-specific demethylase 5A; LOW QUALITY PROTEIN: lysine-specific demethylase 5A
    Names
    jumonji, AT rich interactive domain 1A
    XP_005637389.2
    XP_038295289.1
    XP_038295290.1
    XP_038315579.1
    XP_038369946.1
    XP_038432323.1
    XP_038432324.1
    XP_038497795.1
    XP_038497796.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051831.1 Reference ROS_Cfam_1.0

      Range
      42718407..42806253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038439361.1 → XP_038295289.1  lysine-specific demethylase 5A isoform X1

      UniProtKB/TrEMBL
      A0A8C0N9P9, A0A8C0R197, A0A8I3PT80, A0A8P0PL09
      Related
      ENSCAFP00845037794.1, ENSCAFT00845048183.1
      Conserved Domains (8) summary
      smart00545
      Location:18 → 59
      JmjN; Small domain found in the jumonji family of transcription factors
      cd15602
      Location:295 → 343
      PHD1_KDM5A; PHD finger 1 found in Lysine-specific demethylase 5A (KDM5A)
      cd15606
      Location:1163 → 1215
      PHD2_KDM5A; PHD finger 2 found in Lysine-specific demethylase 5A (KDM5A)
      cd15686
      Location:1608 → 1659
      PHD3_KDM5A; PHD finger 3 found in Lysine-specific demethylase 5A (KDM5A)
      cd16873
      Location:84 → 175
      ARID_KDM5A; ARID/BRIGHT DNA binding domain of lysine-specific demethylase 5A (KDM5A)
      pfam02373
      Location:470 → 586
      JmjC; JmjC domain, hydroxylase
      pfam02928
      Location:676 → 728
      zf-C5HC2; C5HC2 zinc finger
      pfam08429
      Location:741 → 1070
      PLU-1; PLU-1-like protein

    2. XM_038439362.1 → XP_038295290.1  lysine-specific demethylase 5A isoform X2

      UniProtKB/TrEMBL
      A0A8C0NK26, A0A8C0NKG7, A0A8I3Q276
      Related
      ENSCAFP00845038156.1, ENSCAFT00845048641.1
      Conserved Domains (8) summary
      smart00545
      Location:18 → 59
      JmjN; Small domain found in the jumonji family of transcription factors
      cd15602
      Location:295 → 343
      PHD1_KDM5A; PHD finger 1 found in Lysine-specific demethylase 5A (KDM5A)
      cd15606
      Location:1163 → 1215
      PHD2_KDM5A; PHD finger 2 found in Lysine-specific demethylase 5A (KDM5A)
      cd16873
      Location:84 → 175
      ARID_KDM5A; ARID/BRIGHT DNA binding domain of lysine-specific demethylase 5A (KDM5A)
      pfam02373
      Location:470 → 586
      JmjC; JmjC domain, hydroxylase
      pfam02928
      Location:676 → 728
      zf-C5HC2; C5HC2 zinc finger
      pfam08429
      Location:741 → 1070
      PLU-1; PLU-1-like protein
      cl22851
      Location:1608 → 1622
      PHD_SF; PHD finger superfamily

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049287.1 Alternate UMICH_Zoey_3.1

      Range
      42663789..42745548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038514018.1 → XP_038369946.1  LOW QUALITY PROTEIN: lysine-specific demethylase 5A isoform X1

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

      Range
      42630772..42717451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038641867.1 → XP_038497795.1  lysine-specific demethylase 5A isoform X1

    2. XM_038641868.1 → XP_038497796.1  lysine-specific demethylase 5A isoform X2

      Conserved Domains (8) summary
      smart00545
      Location:18 → 59
      JmjN; Small domain found in the jumonji family of transcription factors
      cd15602
      Location:295 → 343
      PHD1_KDM5A; PHD finger 1 found in Lysine-specific demethylase 5A (KDM5A)
      cd15606
      Location:1163 → 1215
      PHD2_KDM5A; PHD finger 2 found in Lysine-specific demethylase 5A (KDM5A)
      cd16873
      Location:84 → 175
      ARID_KDM5A; ARID/BRIGHT DNA binding domain of lysine-specific demethylase 5A (KDM5A)
      pfam02373
      Location:470 → 586
      JmjC; JmjC domain, hydroxylase
      pfam02928
      Location:676 → 728
      zf-C5HC2; C5HC2 zinc finger
      pfam08429
      Location:741 → 1070
      PLU-1; PLU-1-like protein
      cl22851
      Location:1608 → 1622
      PHD_SF; PHD finger superfamily

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

      Range
      3597143..3683827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038576396.1 → XP_038432324.1  lysine-specific demethylase 5A isoform X2

      UniProtKB/TrEMBL
      A0A8C0NK26, A0A8C0NKG7, A0A8I3Q276
      Conserved Domains (8) summary
      smart00545
      Location:18 → 59
      JmjN; Small domain found in the jumonji family of transcription factors
      cd15602
      Location:295 → 343
      PHD1_KDM5A; PHD finger 1 found in Lysine-specific demethylase 5A (KDM5A)
      cd15606
      Location:1163 → 1215
      PHD2_KDM5A; PHD finger 2 found in Lysine-specific demethylase 5A (KDM5A)
      cd16873
      Location:84 → 175
      ARID_KDM5A; ARID/BRIGHT DNA binding domain of lysine-specific demethylase 5A (KDM5A)
      pfam02373
      Location:470 → 586
      JmjC; JmjC domain, hydroxylase
      pfam02928
      Location:676 → 728
      zf-C5HC2; C5HC2 zinc finger
      pfam08429
      Location:741 → 1070
      PLU-1; PLU-1-like protein
      cl22851
      Location:1608 → 1622
      PHD_SF; PHD finger superfamily

    2. XM_038576395.1 → XP_038432323.1  lysine-specific demethylase 5A isoform X1

      UniProtKB/TrEMBL
      A0A8C0N9P9, A0A8C0R197, A0A8I3PT80, A0A8P0PL09
      Conserved Domains (8) summary
      smart00545
      Location:18 → 59
      JmjN; Small domain found in the jumonji family of transcription factors
      cd15602
      Location:295 → 343
      PHD1_KDM5A; PHD finger 1 found in Lysine-specific demethylase 5A (KDM5A)
      cd15606
      Location:1163 → 1215
      PHD2_KDM5A; PHD finger 2 found in Lysine-specific demethylase 5A (KDM5A)
      cd15686
      Location:1608 → 1659
      PHD3_KDM5A; PHD finger 3 found in Lysine-specific demethylase 5A (KDM5A)
      cd16873
      Location:84 → 175
      ARID_KDM5A; ARID/BRIGHT DNA binding domain of lysine-specific demethylase 5A (KDM5A)
      pfam02373
      Location:470 → 586
      JmjC; JmjC domain, hydroxylase
      pfam02928
      Location:676 → 728
      zf-C5HC2; C5HC2 zinc finger
      pfam08429
      Location:741 → 1070
      PLU-1; PLU-1-like protein

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      4236467..4324130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038459651.1 → XP_038315579.1  lysine-specific demethylase 5A isoform X2

      UniProtKB/TrEMBL
      A0A8C0NK26, A0A8C0NKG7, A0A8I3Q276
      Conserved Domains (8) summary
      smart00545
      Location:18 → 59
      JmjN; Small domain found in the jumonji family of transcription factors
      cd15602
      Location:295 → 343
      PHD1_KDM5A; PHD finger 1 found in Lysine-specific demethylase 5A (KDM5A)
      cd15606
      Location:1163 → 1215
      PHD2_KDM5A; PHD finger 2 found in Lysine-specific demethylase 5A (KDM5A)
      cd16873
      Location:84 → 175
      ARID_KDM5A; ARID/BRIGHT DNA binding domain of lysine-specific demethylase 5A (KDM5A)
      pfam02373
      Location:470 → 586
      JmjC; JmjC domain, hydroxylase
      pfam02928
      Location:676 → 728
      zf-C5HC2; C5HC2 zinc finger
      pfam08429
      Location:741 → 1070
      PLU-1; PLU-1-like protein
      cl22851
      Location:1608 → 1622
      PHD_SF; PHD finger superfamily

    2. XM_005637332.4 → XP_005637389.2  lysine-specific demethylase 5A isoform X1

      UniProtKB/TrEMBL
      A0A8C0N9P9, A0A8C0R197, A0A8I3PT80, A0A8P0PL09
      Conserved Domains (8) summary
      smart00545
      Location:18 → 59
      JmjN; Small domain found in the jumonji family of transcription factors
      cd15602
      Location:295 → 343
      PHD1_KDM5A; PHD finger 1 found in Lysine-specific demethylase 5A (KDM5A)
      cd15606
      Location:1163 → 1215
      PHD2_KDM5A; PHD finger 2 found in Lysine-specific demethylase 5A (KDM5A)
      cd15686
      Location:1608 → 1659
      PHD3_KDM5A; PHD finger 3 found in Lysine-specific demethylase 5A (KDM5A)
      cd16873
      Location:84 → 175
      ARID_KDM5A; ARID/BRIGHT DNA binding domain of lysine-specific demethylase 5A (KDM5A)
      pfam02373
      Location:470 → 586
      JmjC; JmjC domain, hydroxylase
      pfam02928
      Location:676 → 728
      zf-C5HC2; C5HC2 zinc finger
      pfam08429
      Location:741 → 1070
      PLU-1; PLU-1-like protein
    Nucleotide Protein
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