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    Marchf11 membrane associated ring-CH-type finger 11 [ Mus musculus (house mouse) ]

    Gene ID: 211147, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Marchf11provided by MGI
    Official Full Name
    membrane associated ring-CH-type finger 11provided by MGI
    Primary source
    MGI:MGI:3608327
    See related
    Ensembl:ENSMUSG00000022269 AllianceGenome:MGI:3608327
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    March11; 9630025C22
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in cytoplasmic vesicle membrane. Orthologous to human MARCHF11 (membrane associated ring-CH-type finger 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 147.5) See more
    Orthologs
    human all
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    Genomic context

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    See Marchf11 in Genome Data Viewer
    Location:
    15 B1; 15 9.77 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (26309134..26409672)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (26309048..26409586)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38204 Neighboring gene predicted gene, 41279 Neighboring gene STARR-seq mESC enhancer starr_38206 Neighboring gene predicted gene, 57625 Neighboring gene STARR-seq mESC enhancer starr_38207 Neighboring gene predicted gene, 52201 Neighboring gene STARR-seq mESC enhancer starr_38209 Neighboring gene STARR-seq mESC enhancer starr_38210 Neighboring gene predicted gene, 36790 Neighboring gene predicted gene, 52206 Neighboring gene F-box and leucine-rich repeat protein 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of SAMT family proteins as substrates of MARCH11 in mouse spermatids. Yogo K, et al. Histochem Cell Biol, 2012 Jan. PMID 22075566
    2. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
    3. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF11
    Names
    E3 ubiquitin-protein ligase MARCH11
    MARCH-XI
    RING-type E3 ubiquitin transferase MARCH11
    RING-type E3 ubiquitin transferase MARCHF11
    membrane-associated RING finger protein 11
    membrane-associated RING-CH protein XI
    membrane-associated ring finger (C3HC4) 11
    NP_001297703.1
    NP_808265.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310774.1 → NP_001297703.1  E3 ubiquitin-protein ligase MARCHF11 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon, which results in a frameshift compared to variant 1. The resulting isoform (2) is shorter with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK035990, AK162044, BF467885
      Consensus CDS
      CCDS79365.1
      UniProtKB/TrEMBL
      D3YXE6
      Related
      ENSMUSP00000120622.2, ENSMUST00000152841.2
      Conserved Domains (1) summary
      smart00744
      Location:167 → 213
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    2. NM_177597.6 → NP_808265.2  E3 ubiquitin-protein ligase MARCHF11 isoform 1

      See identical proteins and their annotated locations for NP_808265.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK035990, AK162044, BF467885, BU961611
      Consensus CDS
      CCDS27401.2
      UniProtKB/Swiss-Prot
      B9EIG0, Q8CBH7
      Related
      ENSMUSP00000118729.2, ENSMUST00000140840.8
      Conserved Domains (1) summary
      smart00744
      Location:167 → 213
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      26309134..26409672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CBH7.2 GenPept UniProtKB/Swiss-Prot:Q8CBH7

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