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    Spon1 spondin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64456, updated on 27-Nov-2024

    Summary

    Official Symbol
    Spon1provided by RGD
    Official Full Name
    spondin 1provided by RGD
    Primary source
    RGD:619918
    See related
    EnsemblRapid:ENSRNOG00000058003 AllianceGenome:RGD:619918
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sponf
    Summary
    Predicted to enable LBD domain binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within negative regulation of amyloid-beta formation; positive regulation of amyloid precursor protein catabolic process; and positive regulation of protein processing. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human SPON1 (spondin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 310.7), Kidney (RPKM 268.6) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Spon1 in Genome Data Viewer
    Location:
    1q33
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (177363526..177662689)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (167929049..168228239)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (178568777..178935715)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484911 Neighboring gene uncharacterized LOC102548271 Neighboring gene 60S ribosomal protein L31 pseudogene Neighboring gene uncharacterized LOC134483774 Neighboring gene RAS related 2 Neighboring gene ribosomal protein L27a, pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Clone Names

    • MGC124557

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables LBD domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables LBD domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    spondin-1
    Names
    f-spondin
    spondin 1, (f-spondin) extracellular matrix protein
    spondin 1, extracellular matrix protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172067.2NP_742064.2  spondin-1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P35446
      UniProtKB/TrEMBL
      A0A0G2K775, F1LND6, Q3B7D6
      Related
      ENSRNOP00000074092.1, ENSRNOT00000092099.3
      Conserved Domains (4) summary
      cd08544
      Location:43182
      Reeler; the N-terminal domain of reelin, F-spondin, and a variety of other proteins
      pfam00090
      Location:562610
      TSP_1; Thrombospondin type 1 domain
      pfam06468
      Location:205392
      Spond_N; Spondin_N
      pfam19028
      Location:669720
      TSP1_spondin; Spondin-like TSP1 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      177363526..177662689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)