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    Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84347, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cacng2provided by RGD
    Official Full Name
    calcium voltage-gated channel auxiliary subunit gamma 2provided by RGD
    Primary source
    RGD:71095
    See related
    EnsemblRapid:ENSRNOG00000065511 AllianceGenome:RGD:71095
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ipr328
    Summary
    Enables ionotropic glutamate receptor binding activity. Involved in several processes, including eye blink reflex; positive regulation of AMPA receptor activity; and positive regulation of protein localization to basolateral plasma membrane. Located in cell surface; cerebellar mossy fiber; and postsynaptic density membrane. Part of AMPA glutamate receptor complex. Biomarker of childhood absence epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 10. Orthologous to human CACNG2 (calcium voltage-gated channel auxiliary subunit gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 36.3) See more
    Orthologs
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    Genomic context

    See Cacng2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (111451605..111579071, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (109572838..109698516, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (119228112..119353332, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553765 Neighboring gene eukaryotic translation initiation factor 3, subunit D Neighboring gene uncharacterized LOC102554213 Neighboring gene intraflagellar transport 27

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel regulator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ionotropic glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated calcium channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in eye blink reflex IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within membrane hyperpolarization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nervous system process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuromuscular junction development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurotransmitter receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurotransmitter receptor transport, postsynaptic endosome to lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of AMPA receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein localization to basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in postsynaptic neurotransmitter receptor diffusion trapping IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in postsynaptic neurotransmitter receptor diffusion trapping ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of AMPA receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to calcium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in transmission of nerve impulse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within transmission of nerve impulse ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of AMPA glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of AMPA glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cerebellar mossy fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in hippocampal mossy fiber to CA3 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in somatodendritic compartment ISO
    Inferred from Sequence Orthology
    more info
     
    part_of voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    voltage-dependent calcium channel gamma-2 subunit
    Names
    TARP gamma-2
    calcium channel, voltage-dependent, gamma subunit 2
    neuronal voltage-gated calcium channel gamma-2 subunit
    stargazin
    transmembrane AMPAR regulatory protein gamma-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053351.2NP_445803.2  voltage-dependent calcium channel gamma-2 subunit

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q71RJ2
      UniProtKB/TrEMBL
      Q99PR9
      Related
      ENSRNOP00000085982.1, ENSRNOT00000106728.2
      Conserved Domains (1) summary
      pfam00822
      Location:6197
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      111451605..111579071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595135.3XP_017450624.1  voltage-dependent calcium channel gamma-2 subunit isoform X1

      UniProtKB/TrEMBL
      Q99PR9
      Conserved Domains (1) summary
      cl21598
      Location:1174
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family