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    rskd-1 PX domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179685, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rskd-1
    Official Full Name
    PX domain-containing protein
    Primary source
    WormBase:WBGene00010096
    Locus tag
    CELE_F55C5.7
    See related
    AllianceGenome:WB:WBGene00010096
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity; phosphatidylinositol binding activity; and protein kinase activity. Predicted to be involved in protein phosphorylation. Is expressed in GABAergic neurons; rectal muscle; retrovesicular ganglion; and somatic nervous system. Orthologous to several human genes including RPS6KC1 (ribosomal protein S6 kinase C1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rskd-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    10
    Sequence:
    Chromosome: V; NC_003283.11 (12284060..12288615, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Uncharacterized protein Neighboring gene Signal recognition particle subunit SRP68 Neighboring gene Serpentine Receptor, class H

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of cross-linked peptides from complex samples. Yang B, et al. Nat Methods, 2012 Sep. PMID 22772728
    2. Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development. Arur S, et al. Proc Natl Acad Sci U S A, 2009 Mar 24. PMID 19264959, Free PMC Article
    3. A pathway for phagosome maturation during engulfment of apoptotic cells. Kinchen JM, et al. Nat Cell Biol, 2008 May. PMID 18425118, Free PMC Article
    4. A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans. Updike DL, et al. Genetics, 2009 Dec. PMID 19805813, Free PMC Article
    5. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PX domain-containing protein
    NP_001122957.1
    • Confirmed by transcript evidence
    NP_506082.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12284060..12288615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073681.8 → NP_506082.2  PX domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506082.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20821
      Conserved Domains (3) summary
      cd06881
      Location:26 → 150
      PX_SNX15_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 15-like proteins
      cd02677
      Location:251 → 324
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cl21453
      Location:601 → 783
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001129485.3 → NP_001122957.1  PX domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122957.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WHT6
      Conserved Domains (1) summary
      cl02563
      Location:26 → 150
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    Nucleotide Protein
    Heading Accession and Version

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