dcap-2 m7GpppN-mRNA hydrolase dcap-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dcap-2
Official Full Name: m7GpppN-mRNA hydrolase dcap-2
Primary source: WormBase:WBGene00003582
Locus tag: CELE_F52G2.1
See related: AllianceGenome:WB:WBGene00003582
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity. Involved in several processes, including deadenylation-dependent decapping of nuclear-transcribed mRNA; determination of adult lifespan; and nematode larval development. Located in P granule and P-body. Orthologous to human DCP2 (decapping mRNA 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dcap-2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (13513369..13521870, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Signaling by AWC Olfactory Neurons Is Necessary for Caenorhabditis elegans' Response to Prenol, an Odor Associated with Nematode-Infected Insects.
Title: Signaling by AWC Olfactory Neurons Is Necessary for Caenorhabditis elegans' Response to Prenol, an Odor Associated with Nematode-Infected Insects.
Loss of the mRNA decapping complex activity acting in the 5'-3' mRNA decay pathway inhibits dauer formation at the stressful high temperature of 27.5 degrees C, and instead promotes early developmental arrest.
Title: Neuronal function of the mRNA decapping complex determines survival of Caenorhabditis elegans at high temperature through temporal regulation of heterochronic gene expression.
Caenorhabditis elegans Dcp2 is localized to distinct foci during embryogenesis.
Title: Caenorhabditis elegans decapping proteins: localization and functional analysis of Dcp1, Dcp2, and DcpS during embryogenesis.
Dcp2 activity can be influenced by both sequence and context, and Dcp2 may contribute to gene regulation in multiple RNA pathways, including monomethyl- and trimethylguanosine-capped RNAs
Title: Dcp2 Decaps m2,2,7GpppN-capped RNAs, and its activity is sequence and context dependent.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS4-243 (e-PCR)
- UniSTS:242239

F52G2.1a (e-PCR)
- UniSTS:320080

Y45F10A.1 (e-PCR)
- UniSTS:313313

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA	IDA Inferred from Direct Assay more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
involved_in regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to UV	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: m7GpppN-mRNA hydrolase dcap-2

NP_001293937.1

Confirmed by transcript evidence

NP_001293938.1

Confirmed by transcript evidence

NP_502608.3

Confirmed by transcript evidence

NP_502609.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

13513369..13521870 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_070207.7 → NP_502608.3 m7GpppN-mRNA hydrolase dcap-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502608.3

Status: REVIEWED

UniProtKB/Swiss-Prot

O62255

Conserved Domains (2) summary

cd03672
Location:224 → 370

Dcp2p; mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical ...

pfam05026
Location:136 → 221

DCP2; Dcp2, box A domain
NM_070208.6 → NP_502609.2 m7GpppN-mRNA hydrolase dcap-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502609.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A061ACN4, A0A061ADX7, B3VKU3, O62255, O62257, Q2YS49, Q2YS50, Q45F95

Conserved Domains (2) summary

cd03672
Location:240 → 386

Dcp2p; mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical ...

pfam05026
Location:152 → 237

DCP2; Dcp2, box A domain
NM_001307008.3 → NP_001293937.1 m7GpppN-mRNA hydrolase dcap-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293937.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061ADX7

Conserved Domains (3) summary

PHA03247
Location:318 → 559

PHA03247; large tegument protein UL36; Provisional

cd03672
Location:140 → 286

Dcp2p; mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical ...

pfam05026
Location:52 → 136

DCP2; Dcp2, box A domain
NM_001307009.3 → NP_001293938.1 m7GpppN-mRNA hydrolase dcap-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293938.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061ACN4

Conserved Domains (3) summary

PHA03247
Location:228 → 469

PHA03247; large tegument protein UL36; Provisional

cd03672
Location:50 → 196

Dcp2p; mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical ...

pfam05026
Location:10 → 46

DCP2; Dcp2, box A domain