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    tnk2b tyrosine kinase, non-receptor, 2b [ Syngnathus acus (greater pipefish) ]

    Gene ID: 119136967, updated on 21-Mar-2024

    Summary

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    Gene symbol
    tnk2b
    Gene description
    tyrosine kinase, non-receptor, 2b
    See related
    EnsemblRapid:ENSSACG00010016178
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Syngnathus acus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Syngnathiaria; Syngnathiformes; Syngnathoidei; Syngnathidae; Syngnathus
    Orthologs
    human zebrafish all
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    Genomic context

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    See tnk2b in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    100 current fSynAcu1.2 (GCF_901709675.1) 17 NC_051102.1 (841760..885316)

    Chromosome 17 - NC_051102.1Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 15 Neighboring gene transferrin receptor 1a Neighboring gene pinopsin-like Neighboring gene uncharacterized LOC119137024

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_051102.1 Chromosome 17 Reference fSynAcu1.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of keratinocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine kinase, non-receptor, 2b

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Syngnathus acus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference fSynAcu1.2

    Genomic

    1. NC_051102.1 Reference fSynAcu1.2

      Range
      841760..885316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_037275876.1 → XP_037131771.1  tyrosine kinase, non-receptor, 2b isoform X5

      Conserved Domains (7) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      cd14274
      Location:1078 → 1121
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1108 → 1147
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:147 → 406
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:468 → 533
      GTPase_binding; GTPase binding
      pfam11555
      Location:853 → 941
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:414 → 463
      SH3_9; Variant SH3 domain

    2. XM_037275870.1 → XP_037131765.1  tyrosine kinase, non-receptor, 2b isoform X1

      Conserved Domains (7) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      cd14274
      Location:1110 → 1153
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1140 → 1179
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:179 → 438
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:500 → 565
      GTPase_binding; GTPase binding
      pfam11555
      Location:885 → 973
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:446 → 495
      SH3_9; Variant SH3 domain

    3. XM_037275871.1 → XP_037131766.1  tyrosine kinase, non-receptor, 2b isoform X1

      Conserved Domains (7) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      cd14274
      Location:1110 → 1153
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1140 → 1179
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:179 → 438
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:500 → 565
      GTPase_binding; GTPase binding
      pfam11555
      Location:885 → 973
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:446 → 495
      SH3_9; Variant SH3 domain

    4. XM_037275875.1 → XP_037131770.1  tyrosine kinase, non-receptor, 2b isoform X4

      Conserved Domains (7) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      cd14274
      Location:1084 → 1127
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1114 → 1153
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:179 → 438
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:500 → 565
      GTPase_binding; GTPase binding
      pfam11555
      Location:859 → 947
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:446 → 495
      SH3_9; Variant SH3 domain

    5. XM_037275877.1 → XP_037131772.1  tyrosine kinase, non-receptor, 2b isoform X6

      Conserved Domains (7) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      cd14274
      Location:1069 → 1112
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1099 → 1138
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:179 → 438
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:500 → 565
      GTPase_binding; GTPase binding
      pfam11555
      Location:844 → 932
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:446 → 495
      SH3_9; Variant SH3 domain

    6. XM_037275874.1 → XP_037131769.1  tyrosine kinase, non-receptor, 2b isoform X3

      Related
      ENSSACP00010023756.1, ENSSACT00010026148.1
      Conserved Domains (7) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      cd14274
      Location:1110 → 1153
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1140 → 1179
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:179 → 438
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:500 → 565
      GTPase_binding; GTPase binding
      pfam11555
      Location:885 → 973
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:446 → 495
      SH3_9; Variant SH3 domain

    7. XM_037275872.1 → XP_037131767.1  tyrosine kinase, non-receptor, 2b isoform X2

      Conserved Domains (7) summary
      cd09539
      Location:32 → 93
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      cd14274
      Location:1104 → 1147
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1134 → 1173
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:173 → 432
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:494 → 559
      GTPase_binding; GTPase binding
      pfam11555
      Location:879 → 967
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:440 → 489
      SH3_9; Variant SH3 domain

    8. XM_037275878.1 → XP_037131773.1  tyrosine kinase, non-receptor, 2b isoform X7

      Related
      ENSSACP00010023752.1, ENSSACT00010026144.1
      Conserved Domains (7) summary
      cd09539
      Location:32 → 93
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      cd14274
      Location:1063 → 1106
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1093 → 1132
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:173 → 432
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:494 → 559
      GTPase_binding; GTPase binding
      pfam11555
      Location:838 → 926
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:440 → 489
      SH3_9; Variant SH3 domain

    9. XM_037275879.1 → XP_037131774.1  tyrosine kinase, non-receptor, 2b isoform X8

      Conserved Domains (6) summary
      cd14274
      Location:889 → 932
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:919 → 958
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      pfam09027
      Location:279 → 344
      GTPase_binding; GTPase binding
      pfam11555
      Location:664 → 752
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:225 → 274
      SH3_9; Variant SH3 domain
      cl21453
      Location:32 → 217
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
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