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    Stx1b syntaxin 1B [ Mus musculus (house mouse) ]

    Gene ID: 56216, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stx1bprovided by MGI
    Official Full Name
    syntaxin 1Bprovided by MGI
    Primary source
    MGI:MGI:1930705
    See related
    Ensembl:ENSMUSG00000030806 AllianceGenome:MGI:1930705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Stx1b; Syn1b; Stx1b2; Stx1bl
    Summary
    Enables protein kinase binding activity and signaling receptor binding activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of synaptic vesicle recycling; and neurotransmitter secretion. Located in axon; plasma membrane; and presynapse. Is active in neuromuscular junction and presynaptic active zone membrane. Is expressed in forebrain and retina layer. Human ortholog(s) of this gene implicated in generalized epilepsy with febrile seizures plus 9. Orthologous to human STX1B (syntaxin 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 100.1), frontal lobe adult (RPKM 87.7) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Stx1b in Genome Data Viewer
    Location:
    7 F3; 7 69.75 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127403072..127423703, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127803900..127824531, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene SET domain containing 1A Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Neighboring gene STARR-positive B cell enhancer ABC_E3755 Neighboring gene syntaxin 4A (placental) Neighboring gene STARR-seq mESC enhancer starr_20194 Neighboring gene zinc finger protein 668 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:135020325-135020434

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in calcium ion-regulated exocytosis of neurotransmitter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of macropinocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of synaptic vesicle recycling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of excitatory postsynaptic potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of neurotransmitter secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of spontaneous neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic vesicle priming IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in spontaneous neurotransmitter secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in spontaneous neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic vesicle docking IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in synaptic vesicle docking IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle docking involved in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuromuscular junction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in nuclear lamina ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in presynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic active zone membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic membrane IC
    Inferred by Curator
    more info
     
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    syntaxin-1B
    Names
    syntaxin 1B1
    syntaxin 1B2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024414.2NP_077725.1  syntaxin-1B

      See identical proteins and their annotated locations for NP_077725.1

      Status: VALIDATED

      Source sequence(s)
      AC149222
      Consensus CDS
      CCDS40146.1
      UniProtKB/Swiss-Prot
      A2RSB4, O35525, P32853, P61264
      Related
      ENSMUSP00000101874.4, ENSMUST00000106267.5
      Conserved Domains (2) summary
      pfam00804
      Location:29226
      Syntaxin
      pfam05739
      Location:227278
      SNARE; SNARE domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      127403072..127423703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241866.1XP_011240168.1  syntaxin-1B isoform X2

      Conserved Domains (2) summary
      pfam00804
      Location:25222
      Syntaxin
      pfam05739
      Location:223274
      SNARE; SNARE domain
    2. XM_006508044.4XP_006508107.1  syntaxin-1B isoform X1

      Conserved Domains (2) summary
      pfam00804
      Location:147344
      Syntaxin
      pfam05739
      Location:345396
      SNARE; SNARE domain
    3. XM_036153269.1XP_036009162.1  syntaxin-1B isoform X3

      Conserved Domains (2) summary
      pfam00804
      Location:1198
      Syntaxin
      pfam05739
      Location:199250
      SNARE; SNARE domain