U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Rbks ribokinase [ Mus musculus (house mouse) ]

    Gene ID: 71336, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rbksprovided by MGI
    Official Full Name
    ribokinaseprovided by MGI
    Primary source
    MGI:MGI:1918586
    See related
    Ensembl:ENSMUSG00000029136 AllianceGenome:MGI:1918586
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RK; RBSK; 5230400M11Rik
    Summary
    Enables ribokinase activity. Involved in pentose-phosphate shunt. Predicted to be located in nucleus. Predicted to be active in cytosol. Is expressed in cerebral cortex; heart; and liver. Orthologous to human RBKS (ribokinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 4.4), testis adult (RPKM 4.2) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rbks in Genome Data Viewer
    Location:
    5 B1; 5 17.27 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31781783..31855042, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31624439..31697649, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AI839979 Neighboring gene STARR-seq mESC enhancer starr_12777 Neighboring gene STARR-positive B cell enhancer ABC_E4750 Neighboring gene STARR-seq mESC enhancer starr_12780 Neighboring gene STARR-seq mESC enhancer starr_12781 Neighboring gene predicted gene, 38424 Neighboring gene mitochondrial ribosomal protein L33 Neighboring gene microRNA 3473e Neighboring gene STARR-positive B cell enhancer ABC_E11723 Neighboring gene BRISC and BRCA1 A complex member 2 Neighboring gene STARR-seq mESC enhancer starr_12782 Neighboring gene STARR-seq mESC enhancer starr_12783 Neighboring gene STARR-seq mESC enhancer starr_12784 Neighboring gene STARR-positive B cell enhancer mm9_chr5:32316174-32316475 Neighboring gene predicted gene, 52770 Neighboring gene STARR-seq mESC enhancer starr_12785 Neighboring gene microRNA 12198 Neighboring gene predicted gene, 40277

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribokinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in D-ribose catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pentose-phosphate shunt IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ribokinase
    NP_001404658.1
    NP_001404659.1
    NP_001404660.1
    NP_694876.1
    XP_006504176.1
    XP_011239073.1
    XP_036021384.1
    XP_036021385.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417729.1NP_001404658.1  ribokinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114613
    2. NM_001417730.1NP_001404659.1  ribokinase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114613
    3. NM_001417731.1NP_001404660.1  ribokinase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC114613
    4. NM_153196.2NP_694876.1  ribokinase isoform 1

      See identical proteins and their annotated locations for NP_694876.1

      Status: VALIDATED

      Source sequence(s)
      AC114613
      Consensus CDS
      CCDS19187.1
      UniProtKB/Swiss-Prot
      Q8R1Q9
      Related
      ENSMUSP00000031018.8, ENSMUST00000031018.10
      Conserved Domains (1) summary
      TIGR02152
      Location:23319
      D_ribokin_bact; ribokinase

    RNA

    1. NR_184568.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114613
    2. NR_184569.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114613
    3. NR_184570.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114613

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      31781783..31855042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165492.1XP_036021385.1  ribokinase isoform X4

      Conserved Domains (1) summary
      cl00192
      Location:1170
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
    2. XM_036165491.1XP_036021384.1  ribokinase isoform X4

      Conserved Domains (1) summary
      cl00192
      Location:1170
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
    3. XM_006504113.5XP_006504176.1  ribokinase isoform X2

      Conserved Domains (1) summary
      cl00192
      Location:23266
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
    4. XM_011240771.4XP_011239073.1  ribokinase isoform X1

      Conserved Domains (1) summary
      cl00192
      Location:23266
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...