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    Rnft2 ring finger protein, transmembrane 2 [ Mus musculus (house mouse) ]

    Gene ID: 269695, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnft2provided by MGI
    Official Full Name
    ring finger protein, transmembrane 2provided by MGI
    Primary source
    MGI:MGI:2442859
    See related
    Ensembl:ENSMUSG00000032850 AllianceGenome:MGI:2442859
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem118; B830028P19Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in positive regulation of ERAD pathway. Predicted to be located in membrane. Is expressed in several structures, including brain; male reproductive gland or organ; parathyroid gland; trachea; and trigeminal nerve. Orthologous to human RNFT2 (ring finger protein, transmembrane 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 9.2), CNS E14 (RPKM 9.0) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnft2 in Genome Data Viewer
    Location:
    5 F; 5 58.2 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (118328799..118388518, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (118190734..118245510, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14188 Neighboring gene predicted gene, 30522 Neighboring gene harakiri, BCL2 interacting protein (contains only BH3 domain) Neighboring gene STARR-positive B cell enhancer ABC_E431 Neighboring gene SREBF pathway regulator in golgi 1 Neighboring gene predicted gene, 25076 Neighboring gene STARR-positive B cell enhancer mm9_chr5:118776989-118777289 Neighboring gene STARR-positive B cell enhancer ABC_E10344 Neighboring gene predicted gene, 46942

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RING finger and transmembrane domain-containing protein 2
    Names
    transmembrane protein 118

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109902.1 → NP_001103372.1  RING finger and transmembrane domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001103372.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and at a single splice boundary, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AW049082, BC057302, BY721494
      Consensus CDS
      CCDS51632.1
      UniProtKB/Swiss-Prot
      Q3UF64, Q8BXI9
      Related
      ENSMUSP00000113749.2, ENSMUST00000121369.8
      Conserved Domains (1) summary
      cd16742
      Location:384 → 423
      RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

    2. NM_172998.3 → NP_766586.2  RING finger and transmembrane domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_766586.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK046850, AW049082, BU611972
      Consensus CDS
      CCDS19611.2
      UniProtKB/Swiss-Prot
      Q3UF64
      Related
      ENSMUSP00000112903.2, ENSMUST00000117177.8
      Conserved Domains (1) summary
      cd16742
      Location:385 → 424
      RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      118328799..118388518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530344.3 → XP_006530407.1  RING finger and transmembrane domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006530407.1

      UniProtKB/Swiss-Prot
      Q3UF64
      Conserved Domains (1) summary
      cd16742
      Location:385 → 424
      RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

    2. XM_036165152.1 → XP_036021045.1  RING finger and transmembrane domain-containing protein 2 isoform X4

      Conserved Domains (1) summary
      cl17238
      Location:384 → 401
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. XM_017320901.2 → XP_017176390.1  RING finger and transmembrane domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q3UF64, Q8BXI9
      Conserved Domains (1) summary
      cd16742
      Location:384 → 423
      RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

    4. XM_006530347.3 → XP_006530410.1  RING finger and transmembrane domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006530410.1

      UniProtKB/Swiss-Prot
      Q3UF64
      Conserved Domains (1) summary
      cd16742
      Location:385 → 424
      RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

    5. XM_006530349.2 → XP_006530412.1  RING finger and transmembrane domain-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006530412.1

      UniProtKB/Swiss-Prot
      Q3UF64, Q8BXI9
      Conserved Domains (1) summary
      cd16742
      Location:384 → 423
      RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

    6. XM_006530348.2 → XP_006530411.1  RING finger and transmembrane domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006530411.1

      UniProtKB/Swiss-Prot
      Q3UF64
      Conserved Domains (1) summary
      cd16742
      Location:385 → 424
      RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

    7. XM_030254537.1 → XP_030110397.1  RING finger and transmembrane domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q3UF64, Q8BXI9
      Conserved Domains (1) summary
      cd16742
      Location:384 → 423
      RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

    8. XM_006530345.2 → XP_006530408.1  RING finger and transmembrane domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006530408.1

      UniProtKB/Swiss-Prot
      Q3UF64
      Conserved Domains (1) summary
      cd16742
      Location:385 → 424
      RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

    9. XM_036165151.1 → XP_036021044.1  RING finger and transmembrane domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q3UF64, Q8BXI9
      Conserved Domains (1) summary
      cd16742
      Location:384 → 423
      RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

    10. XM_006530346.5 → XP_006530409.1  RING finger and transmembrane domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006530409.1

      UniProtKB/Swiss-Prot
      Q3UF64
      Conserved Domains (1) summary
      cd16742
      Location:385 → 424
      RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

    11. XM_006530350.3 → XP_006530413.1  RING finger and transmembrane domain-containing protein 2 isoform X3

      Conserved Domains (1) summary
      cl17238
      Location:385 → 402
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    12. XM_030254539.1 → XP_030110399.1  RING finger and transmembrane domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      D3Z0I9

    13. XM_030254540.2 → XP_030110400.1  RING finger and transmembrane domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      D3Z0I9

    14. XM_030254538.2 → XP_030110398.1  RING finger and transmembrane domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      D3Z0I9
      Related
      ENSMUSP00000120260.2, ENSMUST00000154786.8

    RNA

    1. XR_878686.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UF64.2 GenPept UniProtKB/Swiss-Prot:Q3UF64

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