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    Acnat2 acyl-coenzyme A amino acid N-acyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 209186, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acnat2provided by MGI
    Official Full Name
    acyl-coenzyme A amino acid N-acyltransferase 2provided by MGI
    Primary source
    MGI:MGI:2444345
    See related
    Ensembl:ENSMUSG00000060317 AllianceGenome:MGI:2444345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C730036D15Rik
    Summary
    Predicted to enable N-acyltransferase activity and fatty acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid metabolic process. Predicted to be active in peroxisome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 17.2), kidney adult (RPKM 14.0) and 1 other tissue See more
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    Genomic context

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    See Acnat2 in Genome Data Viewer
    Location:
    4 B1; 4 26.37 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (49374458..49408151, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (49374458..49408151, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene phospholipid phosphatase related 1 Neighboring gene predicted gene, 22685 Neighboring gene tumor suppressor candidate 2 pseudogene Neighboring gene recombination signal binding protein for immunoglobulin kappa J region, pseudogene 1 Neighboring gene predicted gene 12451 Neighboring gene predicted gene 12452 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region, pseudogene 2 Neighboring gene acyl-coenzyme A amino acid N-acyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Novel functions of acyl-CoA thioesterases and acyltransferases as auxiliary enzymes in peroxisomal lipid metabolism. Hunt MC, et al. Prog Lipid Res, 2008 Nov. PMID 18538142
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiolester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    acyl-coenzyme A amino acid N-acyltransferase 2
    Names
    acyl-CoA:amino acid N-acyltransferase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356289.1 → NP_001343218.1  acyl-coenzyme A amino acid N-acyltransferase 2

      Status: VALIDATED

      Source sequence(s)
      AK050308, AK050357, BX537352
      Consensus CDS
      CCDS18171.1
      UniProtKB/Swiss-Prot
      B2D099, Q8BGG9, Q91XC7
      Related
      ENSMUSP00000103326.2, ENSMUST00000107698.8
      Conserved Domains (2) summary
      pfam04775
      Location:15 → 139
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      pfam08840
      Location:206 → 415
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

    2. NM_145368.3 → NP_663343.2  acyl-coenzyme A amino acid N-acyltransferase 2

      See identical proteins and their annotated locations for NP_663343.2

      Status: VALIDATED

      Source sequence(s)
      AK050308, BX537352
      Consensus CDS
      CCDS18171.1
      UniProtKB/Swiss-Prot
      B2D099, Q8BGG9, Q91XC7
      Related
      ENSMUSP00000080256.3, ENSMUST00000081541.9
      Conserved Domains (2) summary
      pfam04775
      Location:15 → 139
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      pfam08840
      Location:206 → 415
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      49374458..49408151 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249969.4 → XP_011248271.1  acyl-coenzyme A amino acid N-acyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_011248271.1

      Conserved Domains (2) summary
      pfam04775
      Location:15 → 140
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      cl21494
      Location:206 → 250
      Abhydrolase; alpha/beta hydrolases

    2. XM_036163935.1 → XP_036019828.1  acyl-coenzyme A amino acid N-acyltransferase 2 isoform X1

      Conserved Domains (2) summary
      pfam04775
      Location:15 → 140
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      cl21494
      Location:206 → 250
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGG9.1 GenPept UniProtKB/Swiss-Prot:Q8BGG9

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