Rapgef3 Rap guanine nucleotide exchange factor (GEF) 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rapgef3provided by MGI
Official Full Name: Rap guanine nucleotide exchange factor (GEF) 3provided by MGI
Primary source: MGI:MGI:2441741
See related: Ensembl:ENSMUSG00000022469 AllianceGenome:MGI:2441741
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Epac; Epac1; 2310016P22Rik; 9330170P05Rik
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in associative learning. Predicted to be located in several cellular components, including basolateral part of cell; brush border membrane; and distal axon. Predicted to be active in plasma membrane. Is expressed in brain; heart; lens; lung; and metanephros. Orthologous to human RAPGEF3 (Rap guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in kidney adult (RPKM 30.5), thymus adult (RPKM 25.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 53.74 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (97637886..97666300, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (97744770..97768419, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Leishmania exploits host cAMP/EPAC/calcineurin signaling to induce an IL-33-mediated anti-inflammatory environment for the establishment of infection.
Title: Leishmania exploits host cAMP/EPAC/calcineurin signaling to induce an IL-33-mediated anti-inflammatory environment for the establishment of infection.
Upregulation of Epac1 Promotes Pericyte Loss by Inducing Mitochondrial Fission, Reactive Oxygen Species Production, and Apoptosis.
Title: Upregulation of Epac1 Promotes Pericyte Loss by Inducing Mitochondrial Fission, Reactive Oxygen Species Production, and Apoptosis.
Epac1 participates in beta1-adrenoreceptor autoantibody-mediated decreased autophagic flux in cardiomyocytes.
Title: Epac1 participates in β(1)-adrenoreceptor autoantibody-mediated decreased autophagic flux in cardiomyocytes.
cAMP-EPAC-PKCepsilon-RIM1alpha signaling regulates presynaptic long-term potentiation and motor learning.
Title: cAMP-EPAC-PKCε-RIM1α signaling regulates presynaptic long-term potentiation and motor learning.
Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet.
Title: Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet.
Electroacupuncture Attenuates Post-Inflammatory IBS-Associated Visceral and Somatic Hypersensitivity and Correlates With the Regulatory Mechanism of Epac1-Piezo2 Axis.
Title: Electroacupuncture Attenuates Post-Inflammatory IBS-Associated Visceral and Somatic Hypersensitivity and Correlates With the Regulatory Mechanism of Epac1-Piezo2 Axis.
Epac1-/- and Epac2-/- mice exhibit deficient epithelial Na+ channel regulation and impaired urinary Na+ conservation.
Title: Epac1-/- and Epac2-/- mice exhibit deficient epithelial Na+ channel regulation and impaired urinary Na+ conservation.
Epac1 regulates TLR4 signaling in the diabetic retinal vasculature.
Title: Epac1 regulates TLR4 signaling in the diabetic retinal vasculature.
Cyclic AMP-binding protein Epac1 acts as a metabolic sensor to promote cardiomyocyte lipotoxicity.
Title: Cyclic AMP-binding protein Epac1 acts as a metabolic sensor to promote cardiomyocyte lipotoxicity.
Intracellular receptor EPAC regulates von Willebrand factor secretion from endothelial cells in a PI3K-/eNOS-dependent manner during inflammation.
Title: Intracellular receptor EPAC regulates von Willebrand factor secretion from endothelial cells in a PI3K-/eNOS-dependent manner during inflammation.

Submit: New GeneRIF Correction See all GeneRIFs (113)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (14) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rapgef3 (e-PCR), detects polymorphism
- UniSTS:507859

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cAMP binding	IEA Inferred from Electronic Annotation more info
enables cAMP binding	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rap protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Rap protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial barrier	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of syncytium formation by plasma membrane fusion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of syncytium formation by plasma membrane fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of syncytium formation by plasma membrane fusion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of syncytium formation by plasma membrane fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral part of cell	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in cortical actin cytoskeleton	IEA Inferred from Electronic Annotation more info
colocalizes_with cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in microvillus	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in photoreceptor cell terminal bouton	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ribbon synapse	ISO Inferred from Sequence Orthology more info
located_in rod bipolar cell terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rap guanine nucleotide exchange factor 3

Names: Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I; exchange protein directly activated by cAMP 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177810.1 → NP_001171281.1 rap guanine nucleotide exchange factor 3 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform (1).

Source sequence(s)

AC104225, AK034265, AK142594, CJ051320

Consensus CDS

CCDS49714.1

UniProtKB/TrEMBL

Q3UQC2

Related

ENSMUSP00000116426.3, ENSMUST00000126854.9

Conserved Domains (4) summary

smart00147
Location:661 → 926

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:247 → 356

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:100 → 223

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:387 → 496

RasGEF_N; RasGEF N-terminal motif
NM_001177811.1 → NP_001171282.1 rap guanine nucleotide exchange factor 3 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.

Source sequence(s)

AC104225, AK034265, AK169430, CJ051320

Consensus CDS

CCDS49713.1

UniProtKB/TrEMBL

E9Q2E5, Q3TES7

Related

ENSMUSP00000120126.3, ENSMUST00000128775.9

Conserved Domains (5) summary

cd06224
Location:392 → 513

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:661 → 909

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

COG0664
Location:268 → 346

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:247 → 356

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:100 → 223

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
NM_001357630.1 → NP_001344559.1 rap guanine nucleotide exchange factor 3 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4.

Source sequence(s)

AC104225

UniProtKB/TrEMBL

Q3UQC2

Conserved Domains (4) summary

cd06224
Location:392 → 513

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:661 → 929

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:247 → 356

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:100 → 223

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
NM_144850.2 → NP_659099.2 rap guanine nucleotide exchange factor 3 isoform 2

See identical proteins and their annotated locations for NP_659099.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.

Source sequence(s)

AC104225

Consensus CDS

CCDS37187.2

UniProtKB/Swiss-Prot

Q8BZK9, Q8R1R1, Q8VCC8

UniProtKB/TrEMBL

Q3UQC2

Related

ENSMUSP00000118148.3, ENSMUST00000129223.9

Conserved Domains (5) summary

cd06224
Location:392 → 513

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:661 → 918

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

COG0664
Location:268 → 346

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:247 → 356

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:100 → 223

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

97637886..97666300 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248523.2 → XP_030104383.1 rap guanine nucleotide exchange factor 3 isoform X9

UniProtKB/TrEMBL

Q3UQC2

Conserved Domains (4) summary

smart00147
Location:661 → 926

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:247 → 356

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:100 → 223

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:387 → 496

RasGEF_N; RasGEF N-terminal motif
XM_036159382.1 → XP_036015275.1 rap guanine nucleotide exchange factor 3 isoform X14

UniProtKB/TrEMBL

H3BK39

Conserved Domains (4) summary

smart00147
Location:568 → 833

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:154 → 263

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00618
Location:294 → 403

RasGEF_N; RasGEF N-terminal motif

cl02442
Location:36 → 130

DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
XM_036159375.1 → XP_036015268.1 rap guanine nucleotide exchange factor 3 isoform X2

UniProtKB/TrEMBL

Q3UQC2

Conserved Domains (4) summary

smart00147
Location:695 → 960

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:281 → 390

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:131 → 257

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:421 → 530

RasGEF_N; RasGEF N-terminal motif
XM_017316583.3 → XP_017172072.1 rap guanine nucleotide exchange factor 3 isoform X4

UniProtKB/TrEMBL

Q3UQC2

Related

ENSMUSP00000135238.2, ENSMUST00000177352.8

Conserved Domains (4) summary

smart00147
Location:692 → 957

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:278 → 387

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:131 → 254

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:418 → 527

RasGEF_N; RasGEF N-terminal motif
XM_017316585.2 → XP_017172074.1 rap guanine nucleotide exchange factor 3 isoform X17

Conserved Domains (2) summary

smart00147
Location:233 → 498

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cl02520
Location:1 → 85

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
XM_030248524.1 → XP_030104384.1 rap guanine nucleotide exchange factor 3 isoform X10

UniProtKB/TrEMBL

Q3UQC2

Conserved Domains (4) summary

smart00147
Location:661 → 915

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:247 → 356

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:100 → 223

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:387 → 496

RasGEF_N; RasGEF N-terminal motif
XM_036159379.1 → XP_036015272.1 rap guanine nucleotide exchange factor 3 isoform X8

UniProtKB/TrEMBL

Q3UQC2

Conserved Domains (4) summary

smart00147
Location:664 → 932

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:250 → 359

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:100 → 226

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:390 → 499

RasGEF_N; RasGEF N-terminal motif
XM_036159378.1 → XP_036015271.1 rap guanine nucleotide exchange factor 3 isoform X8

UniProtKB/TrEMBL

Q3UQC2

Conserved Domains (4) summary

smart00147
Location:664 → 932

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:250 → 359

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:100 → 226

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:390 → 499

RasGEF_N; RasGEF N-terminal motif
XM_036159381.1 → XP_036015274.1 rap guanine nucleotide exchange factor 3 isoform X13

UniProtKB/TrEMBL

H3BK39

Conserved Domains (4) summary

smart00147
Location:571 → 839

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:157 → 266

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00618
Location:297 → 406

RasGEF_N; RasGEF N-terminal motif

cl02442
Location:36 → 133

DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
XM_011245602.4 → XP_011243904.1 rap guanine nucleotide exchange factor 3 isoform X12

UniProtKB/TrEMBL

H3BK39

Conserved Domains (4) summary

smart00147
Location:619 → 887

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:205 → 314

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:58 → 181

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:345 → 454

RasGEF_N; RasGEF N-terminal motif
XM_036159380.1 → XP_036015273.1 rap guanine nucleotide exchange factor 3 isoform X11

UniProtKB/TrEMBL

H3BK39

Conserved Domains (4) summary

smart00147
Location:622 → 890

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:208 → 317

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:58 → 184

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:348 → 457

RasGEF_N; RasGEF N-terminal motif
XM_036159377.1 → XP_036015270.1 rap guanine nucleotide exchange factor 3 isoform X7

UniProtKB/TrEMBL

Q3UQC2

Conserved Domains (4) summary

smart00147
Location:695 → 949

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:281 → 390

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:131 → 257

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:421 → 530

RasGEF_N; RasGEF N-terminal motif
XM_036159376.1 → XP_036015269.1 rap guanine nucleotide exchange factor 3 isoform X5

UniProtKB/TrEMBL

Q3UQC2

Conserved Domains (4) summary

smart00147
Location:695 → 952

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:281 → 390

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:131 → 257

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:421 → 530

RasGEF_N; RasGEF N-terminal motif
XM_036159374.1 → XP_036015267.1 rap guanine nucleotide exchange factor 3 isoform X1

UniProtKB/TrEMBL

Q3UQC2

Conserved Domains (4) summary

smart00147
Location:695 → 963

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:281 → 390

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:131 → 257

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:421 → 530

RasGEF_N; RasGEF N-terminal motif
XM_017316584.3 → XP_017172073.1 rap guanine nucleotide exchange factor 3 isoform X6

UniProtKB/TrEMBL

Q3UQC2

Conserved Domains (4) summary

smart00147
Location:692 → 949

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:278 → 387

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:131 → 254

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:418 → 527

RasGEF_N; RasGEF N-terminal motif
XM_017316582.3 → XP_017172071.1 rap guanine nucleotide exchange factor 3 isoform X3

UniProtKB/TrEMBL

Q3UQC2

Conserved Domains (4) summary

smart00147
Location:692 → 960

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:278 → 387

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:131 → 254

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:418 → 527

RasGEF_N; RasGEF N-terminal motif
XM_011245603.1 → XP_011243905.1 rap guanine nucleotide exchange factor 3 isoform X16

Conserved Domains (2) summary

smart00147
Location:233 → 501

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cl02520
Location:1 → 85

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
XM_036159383.1 → XP_036015276.1 rap guanine nucleotide exchange factor 3 isoform X15

Conserved Domains (2) summary

cd06224
Location:4 → 125

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:273 → 541

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases