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    Triobp TRIO and F-actin binding protein [ Mus musculus (house mouse) ]

    Gene ID: 110253, updated on 9-Dec-2024

    Summary

    Official Symbol
    Triobpprovided by MGI
    Official Full Name
    TRIO and F-actin binding proteinprovided by MGI
    Primary source
    MGI:MGI:1349410
    See related
    Ensembl:ENSMUSG00000033088 AllianceGenome:MGI:1349410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tara; EST478828; mKIAA1662
    Summary
    This gene encodes a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility, and cell growth. The encoded protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in the human gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants have been described [provided by RefSeq, Sep 2012]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 14.9), ovary adult (RPKM 12.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Triobp in Genome Data Viewer
    Location:
    15 E1; 15 37.7 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78831924..78890069)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78947724..79005869)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30368 Neighboring gene STARR-positive B cell enhancer ABC_E10867 Neighboring gene lectin, galactose binding, soluble 1 Neighboring gene nucleolar protein 12 Neighboring gene STARR-positive B cell enhancer ABC_E8975 Neighboring gene predicted gene 10865 Neighboring gene microRNA 6956 Neighboring gene predicted gene, 17753 Neighboring gene H1.0 linker histone

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (2) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stereocilium base IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    TRIO and F-actin-binding protein
    Names
    protein Tara
    trio-associated repeat on actin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024716.1NP_001019887.1  TRIO and F-actin-binding protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) contains a distinct 5' UTR and 5' coding region, which causes translation initiation to occur at a downstream start codon, compared to variant 3. The encoded protein (isoform 1) has a shorter N-terminus when compared to isoform 3.
      Source sequence(s)
      AK085512, BX528408, BY199415, BY761337
      Consensus CDS
      CCDS37138.1
      UniProtKB/TrEMBL
      A0A2U3TZ82
      Related
      ENSMUSP00000105309.3, ENSMUST00000109687.9
      Conserved Domains (3) summary
      cd13275
      Location:56157
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:56149
      PH; PH domain
      cl12013
      Location:380519
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. NM_001039155.1NP_001034244.1  TRIO and F-actin-binding protein isoform 4

      See identical proteins and their annotated locations for NP_001034244.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains a distinct 3' UTR and lacks a portion of the 3' coding region, compared to variant 3. The resulting isoform (4) has a shorter C-terminus when compared to isoform 3.
      Source sequence(s)
      DQ228002
      Consensus CDS
      CCDS88802.1
      UniProtKB/Swiss-Prot
      Q99KW3
      Related
      ENSMUSP00000155397.2, ENSMUST00000140228.8
      Conserved Domains (2) summary
      PHA03247
      Location:378895
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:145515
      PHA03307; transcriptional regulator ICP4; Provisional
    3. NM_001039156.1NP_001034245.1  TRIO and F-actin-binding protein isoform 3

      See identical proteins and their annotated locations for NP_001034245.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest protein (isoform 3).
      Source sequence(s)
      BP768417, CX223548, DQ228000
      Consensus CDS
      CCDS37136.1
      UniProtKB/Swiss-Prot
      Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90, Q99KW3
      Related
      ENSMUSP00000105312.4, ENSMUST00000109690.11
      Conserved Domains (4) summary
      PHA03247
      Location:378899
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:145515
      PHA03307; transcriptional regulator ICP4; Provisional
      COG0419
      Location:16672014
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd13275
      Location:14431544
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    4. NM_138579.4NP_613045.3  TRIO and F-actin-binding protein isoform 5

      See identical proteins and their annotated locations for NP_613045.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an in-frame exon, compared to variant 3, resulting in a shorter protein (isoform 5) when compared to isoform 3.
      Source sequence(s)
      BP768417, BU058377, CA322031, CA751843, CF531000, CF532339, CF533172, CN528900, CX223548, DQ278602
      Consensus CDS
      CCDS37137.1
      UniProtKB/Swiss-Prot
      Q99KW3
      Related
      ENSMUSP00000105311.3, ENSMUST00000109689.9
      Conserved Domains (5) summary
      cd13275
      Location:13971498
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:13971490
      PH; PH domain
      pfam15665
      Location:17261943
      FAM184; Family with sequence similarity 184, A and B
      cl12013
      Location:17211860
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23720
      Location:18341950
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      78831924..78890069
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520284.1XP_006520347.1  TRIO and F-actin-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006520347.1

      Conserved Domains (4) summary
      PHA03247
      Location:379900
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:150516
      PHA03307; transcriptional regulator ICP4; Provisional
      COG0419
      Location:16682015
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd13275
      Location:14441545
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    2. XM_006520286.1XP_006520349.1  TRIO and F-actin-binding protein isoform X3

      Conserved Domains (4) summary
      PHA03247
      Location:379900
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:150516
      PHA03307; transcriptional regulator ICP4; Provisional
      COG0419
      Location:16221969
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd13275
      Location:13981499
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    3. XM_006520287.1XP_006520350.1  TRIO and F-actin-binding protein isoform X4

      Conserved Domains (4) summary
      PHA03247
      Location:379900
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:150516
      PHA03307; transcriptional regulator ICP4; Provisional
      COG0419
      Location:15961943
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd13275
      Location:13721473
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    4. XM_036159070.1XP_036014963.1  TRIO and F-actin-binding protein isoform X5

      Conserved Domains (4) summary
      PHA03247
      Location:378899
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:145515
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:15831942
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13275
      Location:13711472
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    5. XM_036159071.1XP_036014964.1  TRIO and F-actin-binding protein isoform X6

      Conserved Domains (3) summary
      PHA03247
      Location:378899
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:145515
      PHA03307; transcriptional regulator ICP4; Provisional
      cd13275
      Location:13971498
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    6. XM_006520285.3XP_006520348.1  TRIO and F-actin-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006520348.1

      Conserved Domains (4) summary
      PHA03247
      Location:379900
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:150516
      PHA03307; transcriptional regulator ICP4; Provisional
      COG0419
      Location:16682015
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd13275
      Location:14441545
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    7. XM_017316365.3XP_017171854.1  TRIO and F-actin-binding protein isoform X2

      UniProtKB/Swiss-Prot
      Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90, Q99KW3
      Conserved Domains (4) summary
      PHA03247
      Location:378899
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:145515
      PHA03307; transcriptional regulator ICP4; Provisional
      COG0419
      Location:16672014
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd13275
      Location:14431544
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    8. XM_006520289.2XP_006520352.1  TRIO and F-actin-binding protein isoform X7

      Conserved Domains (2) summary
      cd13275
      Location:93194
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02168
      Location:366664
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    9. XM_006520291.4XP_006520354.1  TRIO and F-actin-binding protein isoform X9

      UniProtKB/TrEMBL
      G5E8W1
      Related
      ENSMUSP00000122988.4, ENSMUST00000130663.10
      Conserved Domains (1) summary
      cd13275
      Location:56157
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    10. XM_036159072.1XP_036014965.1  TRIO and F-actin-binding protein isoform X8

      Conserved Domains (2) summary
      cd13275
      Location:27128
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02168
      Location:300598
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type