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    Slc35d2 solute carrier family 35, member D2 [ Mus musculus (house mouse) ]

    Gene ID: 70484, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc35d2provided by MGI
    Official Full Name
    solute carrier family 35, member D2provided by MGI
    Primary source
    MGI:MGI:1917734
    See related
    Ensembl:ENSMUSG00000033114 AllianceGenome:MGI:1917734
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    hfrc; SQV7L; UGTrel8; mUGTrel8; 5730408I21Rik
    Summary
    Predicted to enable antiporter activity and pyrimidine nucleotide-sugar transmembrane transporter activity. Predicted to be involved in nucleotide-sugar transmembrane transport. Predicted to act upstream of with a positive effect on heparan sulfate proteoglycan biosynthetic process. Predicted to be active in Golgi membrane. Orthologous to human SLC35D2 (solute carrier family 35 member D2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver adult (RPKM 6.4), bladder adult (RPKM 3.9) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc35d2 in Genome Data Viewer
    Location:
    13 B3; 13 33.26 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (64244122..64277195, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (64096308..64129381, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30999 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 3 Neighboring gene zinc finger protein 367 Neighboring gene STARR-seq mESC enhancer starr_34820 Neighboring gene STARR-positive B cell enhancer ABC_E5404 Neighboring gene STARR-positive B cell enhancer ABC_E928 Neighboring gene STARR-positive B cell enhancer ABC_E7250 Neighboring gene hyaluronic acid binding protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family. Ishida N, et al. Genomics, 2005 Jan. PMID 15607426
    2. Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection. Suda T, et al. J Biol Chem, 2004 Jun 18. PMID 15082721
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130109, MGC130110

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables UDP-N-acetylgalactosamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-N-acetylglucosamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-N-acetylglucosamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables UDP-glucose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables UDP-glucuronic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide-sugar transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide-sugar transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP-glucose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_positive_effect heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect heparan sulfate proteoglycan biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nucleotide-sugar transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nucleotide sugar transporter SLC35D2
    Names
    UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
    UDP-galactose transporter-related protein 8
    UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001321.3 → NP_001001321.2  nucleotide sugar transporter SLC35D2

      See identical proteins and their annotated locations for NP_001001321.2

      Status: PROVISIONAL

      Source sequence(s)
      AK159148
      Consensus CDS
      CCDS26595.1
      UniProtKB/Swiss-Prot
      Q3TXR0, Q762D4, Q762D5, Q811G6
      UniProtKB/TrEMBL
      A0A0R4J181
      Related
      ENSMUSP00000097040.5, ENSMUST00000099441.6
      Conserved Domains (1) summary
      pfam03151
      Location:16 → 301
      TPT; Triose-phosphate Transporter family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      64244122..64277195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517373.4 → XP_006517436.1  nucleotide sugar transporter SLC35D2 isoform X3

      UniProtKB/Swiss-Prot
      Q3TXR0, Q762D4, Q762D5, Q811G6
      Conserved Domains (1) summary
      cl26744
      Location:55 → 238
      TPT; Triose-phosphate Transporter family

    2. XM_006517372.4 → XP_006517435.1  nucleotide sugar transporter SLC35D2 isoform X1

      UniProtKB/Swiss-Prot
      Q3TXR0, Q762D4, Q762D5, Q811G6
      UniProtKB/TrEMBL
      A0A1Y7VL74
      Related
      ENSMUSP00000152341.2, ENSMUST00000220792.2
      Conserved Domains (1) summary
      cl26744
      Location:16 → 228
      TPT; Triose-phosphate Transporter family

    3. XM_006517374.4 → XP_006517437.1  nucleotide sugar transporter SLC35D2 isoform X4

      Conserved Domains (1) summary
      cl26744
      Location:12 → 195
      TPT; Triose-phosphate Transporter family

    4. XM_036158165.1 → XP_036014058.1  nucleotide sugar transporter SLC35D2 isoform X4

      Conserved Domains (1) summary
      cl26744
      Location:12 → 195
      TPT; Triose-phosphate Transporter family

    5. XM_036158164.1 → XP_036014057.1  nucleotide sugar transporter SLC35D2 isoform X2

      UniProtKB/Swiss-Prot
      Q3TXR0, Q762D4, Q762D5, Q811G6
      Conserved Domains (1) summary
      cl26744
      Location:2 → 249
      TPT; Triose-phosphate Transporter family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q762D5.1 GenPept UniProtKB/Swiss-Prot:Q762D5

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