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    Gkap1 G kinase anchoring protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 56278, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gkap1provided by MGI
    Official Full Name
    G kinase anchoring protein 1provided by MGI
    Primary source
    MGI:MGI:1891694
    See related
    Ensembl:ENSMUSG00000021552 AllianceGenome:MGI:1891694
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    42kDa; Gkap42; D13Ertd340e; 4933400B15Rik
    Summary
    Predicted to enable identical protein binding activity. Involved in positive regulation of insulin receptor signaling pathway and signal transduction. Located in Golgi apparatus. Is expressed in several structures, including aorta; genitourinary system; gut gland; nervous system; and trachea. Orthologous to human GKAP1 (G kinase anchoring protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 36.7), placenta adult (RPKM 11.9) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gkap1 in Genome Data Viewer
    Location:
    13 B1; 13 30.97 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (58381160..58422691, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (58233346..58274877, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ubiquilin 1 Neighboring gene STARR-seq mESC enhancer starr_34674 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_34675 Neighboring gene STARR-seq mESC enhancer starr_34676 Neighboring gene predicted gene, 26555 Neighboring gene STARR-seq mESC enhancer starr_34677 Neighboring gene kinesin family member 27 Neighboring gene STARR-seq mESC enhancer starr_34678 Neighboring gene microRNA 6369 Neighboring gene STARR-seq mESC enhancer starr_34680 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:58474531-58474732 Neighboring gene Q-nucleotide N-glycosylase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional role of GKAP1 in the regulation of male germ cell spontaneous apoptosis and sperm number. Wang H, et al. Mol Reprod Dev, 2019 Sep. PMID 31318116
    2. Tumor necrosis factor (TNF)-α-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Iα causes insulin resistance in 3T3-L1 adipocytes. Ando Y, et al. J Biol Chem, 2015 Feb 27. PMID 25586176, Free PMC Article
    3. Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha. Yuasa K, et al. J Biol Chem, 2000 Feb 18. PMID 10671526
    4. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Zhao X, et al. Cell Res, 2014 Dec. PMID 25412662, Free PMC Article
    5. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G kinase-anchoring protein 1
    Names
    42 kD cGMP-dependent protein kinase anchoring protein
    cGMP-dependent protein kinase anchoring protein
    cGMP-dependent protein kinase-anchoring protein of 42 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019832.4 → NP_062806.1  G kinase-anchoring protein 1

      See identical proteins and their annotated locations for NP_062806.1

      Status: VALIDATED

      Source sequence(s)
      BC052347, W84281
      Consensus CDS
      CCDS36684.1
      UniProtKB/Swiss-Prot
      Q9CUD8, Q9JMB0
      Related
      ENSMUSP00000089169.5, ENSMUST00000091579.6
      Conserved Domains (1) summary
      COG1196
      Location:188 → 349
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      58381160..58422691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244542.3 → XP_011242844.1  G kinase-anchoring protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011242844.1

      UniProtKB/Swiss-Prot
      Q9CUD8, Q9JMB0
      Conserved Domains (1) summary
      COG1196
      Location:188 → 349
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_030247329.2 → XP_030103189.1  G kinase-anchoring protein 1 isoform X2

    3. XM_006517304.5 → XP_006517367.1  G kinase-anchoring protein 1 isoform X2

    4. XM_030247330.2 → XP_030103190.1  G kinase-anchoring protein 1 isoform X2

    5. XM_011244543.4 → XP_011242845.1  G kinase-anchoring protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011242845.1

      UniProtKB/Swiss-Prot
      Q9CUD8, Q9JMB0
      Conserved Domains (1) summary
      COG1196
      Location:188 → 349
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. XM_036158099.1 → XP_036013992.1  G kinase-anchoring protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9CUD8, Q9JMB0
      Conserved Domains (1) summary
      COG1196
      Location:188 → 349
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_006517301.3 → XP_006517364.1  G kinase-anchoring protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006517364.1

      UniProtKB/Swiss-Prot
      Q9CUD8, Q9JMB0
      Conserved Domains (1) summary
      COG1196
      Location:188 → 349
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JMB0.1 GenPept UniProtKB/Swiss-Prot:Q9JMB0

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