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    ADF4 actin depolymerizing factor 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836111, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ADF4
    Official Full Name
    actin depolymerizing factor 4
    Primary source
    TAIR:AT5G59890
    Locus tag
    AT5G59890
    See related
    Araport:AT5G59890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    actin depolymerizing factor 4; ACTIN DEPOLYMERIZING FACTOR 4; ATADF4; MMN10.8; MMN10_8
    Summary
    actin depolymerizing factor 4 (ADF4) mRNA, complete cds
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    Genomic context

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    See ADF4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (24122348..24123912)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene actin depolymerizing factor 3 Neighboring gene uncharacterized protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Histone superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ACTIN DEPOLYMERIZING FACTOR4 regulates actin dynamics during innate immune signaling in Arabidopsis. Henty-Ridilla JL, et al. Plant Cell, 2014 Jan. PMID 24464292, Free PMC Article
    2. Arabidopsis Actin-Depolymerizing Factor-4 links pathogen perception, defense activation and transcription to cytoskeletal dynamics. Porter K, et al. PLoS Pathog, 2012. PMID 23144618, Free PMC Article
    3. Arabidopsis actin depolymerizing factor4 modulates the stochastic dynamic behavior of actin filaments in the cortical array of epidermal cells. Henty JL, et al. Plant Cell, 2011 Oct. PMID 22010035, Free PMC Article
    4. Arabidopsis calcium-dependent protein kinase 3 regulates actin cytoskeleton organization and immunity. Lu YJ, et al. Nat Commun, 2020 Dec 4. PMID 33277490, Free PMC Article
    5. Arabidopsis actin-depolymerizing factor AtADF4 mediates defense signal transduction triggered by the Pseudomonas syringae effector AvrPphB. Tian M, et al. Plant Physiol, 2009 Jun. PMID 19346440, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis calcium-dependent protein kinase 3 regulates actin cytoskeleton organization and immunity.
      Title: Arabidopsis calcium-dependent protein kinase 3 regulates actin cytoskeleton organization and immunity.
    2. ADF4 is associated with cytoskeletal rearrangements elicited directly after pathogen perception in plant cells.
      Title: ACTIN DEPOLYMERIZING FACTOR4 regulates actin dynamics during innate immune signaling in Arabidopsis.
    3. a novel role for ADF4 in controlling gene-for-gene resistance activation, as well as MAPK-signaling, via the coordinated regulation of actin cytoskeletal dynamics and R-gene transcription.
      Title: Arabidopsis Actin-Depolymerizing Factor-4 links pathogen perception, defense activation and transcription to cytoskeletal dynamics.
    4. ADF4 contributes to the stochastic dynamic turnover of actin filaments in plant cells.
      Title: Arabidopsis actin depolymerizing factor4 modulates the stochastic dynamic behavior of actin filaments in the cortical array of epidermal cells.
    5. Actin dynamics play a role in the activation of gene-for-gene resistance in Arabidopsis thaliana following inoculation with the phytopathogenic bacterium Pseudomonas syringae pv tomato.
      Title: Arabidopsis actin-depolymerizing factor AtADF4 mediates defense signal transduction triggered by the Pseudomonas syringae effector AvrPphB.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001345374.1
    NM_125382.2
    NM_180897.3

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within innate immune response-activating signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    actin depolymerizing factor 4
    NP_001318843.1
    • actin depolymerizing factor 4 (ADF4); FUNCTIONS IN: actin binding; INVOLVED IN: defense response signaling pathway, resistance gene-dependent, defense response to bacterium; LOCATED IN: intracellular; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Actin-binding, cofilin/tropomyosin type (InterPro:IPR002108); BEST Arabidopsis thaliana protein match is: actin depolymerizing factor 1 (TAIR:AT3G46010.2); Has 1456 Blast hits to 1455 proteins in 265 species: Archae - 0; Bacteria - 5; Metazoa - 592; Fungi - 174; Plants - 513; Viruses - 0; Other Eukaryotes - 172 (source: NCBI BLink).
    NP_851228.1
    • actin depolymerizing factor 4 (ADF4); FUNCTIONS IN: actin binding; INVOLVED IN: defense response signaling pathway, resistance gene-dependent, defense response to bacterium; LOCATED IN: intracellular; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Actin-binding, cofilin/tropomyosin type (InterPro:IPR002108); BEST Arabidopsis thaliana protein match is: actin depolymerizing factor 1 (TAIR:AT3G46010.1); Has 1469 Blast hits to 1466 proteins in 267 species: Archae - 0; Bacteria - 5; Metazoa - 601; Fungi - 174; Plants - 513; Viruses - 0; Other Eukaryotes - 176 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      24122348..24123912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180897.3 → NP_851228.1  actin depolymerizing factor 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851228.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGG7, Q94A13, Q9FJE7, Q9ZSK3
      UniProtKB/TrEMBL
      A0A178UJT7, A0A7G2EU81
      Conserved Domains (1) summary
      cd11286
      Location:6 → 138
      ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors

    2. NM_001345374.1 → NP_001318843.1  actin depolymerizing factor 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EU81
      Conserved Domains (1) summary
      cd11286
      Location:1 → 131
      ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors

    3. NM_125382.2 → NP_568916.2  actin depolymerizing factor 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568916.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EU81
      Conserved Domains (1) summary
      cd11286
      Location:1 → 131
      ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZSK3.2

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