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    D2hgdh D-2-hydroxyglutaric acid dehydrogenase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31184, updated on 9-Dec-2024

    Summary

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    Official Symbol
    D2hgdhprovided by FlyBase
    Official Full Name
    D-2-hydroxyglutaric acid dehydrogenaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023507
    Locus tag
    Dmel_CG3835
    See related
    AllianceGenome:FB:FBgn0023507
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3835; D2HGDH; Dmel\CG3835; EG87B1; EG:87B1.3
    Summary
    Enables (R)-2-hydroxyglutarate dehydrogenase activity. Involved in organic acid metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; anlage in statu nascendi; germline cell; and main body follicle cell. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 1. Orthologous to human D2HGDH (D-2-hydroxyglutarate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See D2hgdh in Genome Data Viewer
    Location:
    2D4-2D4; 1-0.6 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2141489..2144937)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2035522..2038970)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene polyhomeotic distal Neighboring gene polyhomeotic proximal Neighboring gene Phosphogluconate dehydrogenase Neighboring gene bcn92 Neighboring gene wings apart-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Positive Selection at the Polyhomeotic Locus Led to Decreased Thermosensitivity of Gene Expression in Temperate Drosophila melanogaster. Voigt S, et al. Genetics, 2015 Jun. PMID 25855066, Free PMC Article
    2. Evidence that strong positive selection drives neofunctionalization in the tandemly duplicated polyhomeotic genes in Drosophila. Beisswanger S, et al. Proc Natl Acad Sci U S A, 2008 Apr 8. PMID 18381818, Free PMC Article
    3. Linking global histone acetylation to the transcription enhancement of X-chromosomal genes in Drosophila males. Smith ER, et al. J Biol Chem, 2001 Aug 24. PMID 11445559
    4. GAL4 enhancer trap patterns during Drosophila development. Ward EJ, et al. Genesis, 2002 Sep-Oct. PMID 12324946
    5. Loss of the Polycomb group gene polyhomeotic induces non-autonomous cell overproliferation. Feng S, et al. EMBO Rep, 2011 Feb. PMID 21164514, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables (R)-2-hydroxyglutarate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    D-2-hydroxyglutaric acid dehydrogenase
    Names
    CG3835-PA
    CG3835-PB
    CG3835-PC
    D2hgdh-PA
    D2hgdh-PB
    D2hgdh-PC
    NP_569982.1
    NP_726794.1
    NP_726795.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2141489..2144937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166930.2 → NP_726795.1  D-2-hydroxyglutaric acid dehydrogenase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726795.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46096, Q7K511
      Related
      FBpp0070366
      Conserved Domains (3) summary
      COG0277
      Location:85 → 532
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:115 → 252
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:291 → 531
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain

    2. NM_166929.2 → NP_726794.1  D-2-hydroxyglutaric acid dehydrogenase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726794.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46096, Q7K511
      Related
      FBpp0070365
      Conserved Domains (3) summary
      COG0277
      Location:85 → 532
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:115 → 252
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:291 → 531
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain

    3. NM_130626.3 → NP_569982.1  D-2-hydroxyglutaric acid dehydrogenase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569982.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46096, Q7K511
      Related
      FBpp0070367
      Conserved Domains (3) summary
      COG0277
      Location:85 → 532
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:115 → 252
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:291 → 531
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46096 O46096
    Q7K511 Q7K511

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