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    g6pc3 glucose-6-phosphatase catalytic subunit 3 [ Danio rerio (zebrafish) ]

    Gene ID: 790919, updated on 9-Dec-2024

    Summary

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    Official Symbol
    g6pc3provided by ZNC
    Official Full Name
    glucose-6-phosphatase catalytic subunit 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061215-19
    See related
    Ensembl:ENSDARG00000020371 AllianceGenome:ZFIN:ZDB-GENE-061215-19
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:158425
    Summary
    Predicted to enable glucose-6-phosphatase activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. Is expressed in ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in severe congenital neutropenia 4. Orthologous to human G6PC3 (glucose-6-phosphatase catalytic subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See g6pc3 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (3301132..3310677)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (3189472..3199037)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene leucine-rich repeat-containing protein 70 Neighboring gene transmembrane protein 101 Neighboring gene LSM12 homolog b Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2b Neighboring gene cyclin N-terminal domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification, expression and regulation of amphioxus G6Pase gene with an emphasis on origin of liver. Wang Y, et al. Gen Comp Endocrinol, 2015 Apr 1. PMID 25745818
    2. Evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formation. Letelier J, et al. Proc Natl Acad Sci U S A, 2018 Apr 17. PMID 29610331, Free PMC Article
    3. Transforming growth factor-β1 regulates the nascent hematopoietic stem cell niche by promoting gluconeogenesis. Zhang CY, et al. Leukemia, 2018 Feb. PMID 28642593
    4. RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. Saddala MS, et al. BMC Genomics, 2020 Feb 7. PMID 32033529, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables glucose-6-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucose-6-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucose-6-phosphatase 3
    Names
    G-6-Pase 3
    G6Pase 3
    glucose 6 phosphatase, catalytic, 3
    NP_001073535.1
    XP_068080750.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080066.1 → NP_001073535.1  glucose-6-phosphatase 3

      See identical proteins and their annotated locations for NP_001073535.1

      Status: PROVISIONAL

      Source sequence(s)
      BC128866
      UniProtKB/Swiss-Prot
      A1A5Z0
      Related
      ENSDARP00000027964.5, ENSDART00000010569.6
      Conserved Domains (2) summary
      COG0671
      Location:39 → 200
      PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]
      cl00474
      Location:40 → 269
      PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      3301132..3310677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224649.1 → XP_068080750.1  glucose-6-phosphatase 3 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1A5Z0.1 GenPept UniProtKB/Swiss-Prot:A1A5Z0

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