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    Cyp4g15 Cytochrome P450 4g15 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32093, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4g15provided by FlyBase
    Official Full Name
    Cytochrome P450 4g15provided by FlyBase
    Primary source
    FLYBASE:FBgn0030304
    Locus tag
    Dmel_CG11715
    See related
    AllianceGenome:FB:FBgn0030304
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    152658_at; 4g15; CG11715; cyp4g15; CYP4G15; Dmel\CG11715
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; ganglia; larval central nervous system; larval nervous system; and presumptive embryonic/larval central nervous system. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp4g15 in Genome Data Viewer
    Location:
    10B15-10B15; 1-34 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11477058..11483233)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11371091..11377266)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Heterochromatin protein 5 Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-like activating enzyme 5 Neighboring gene Spase 25-subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insights into unique features of Drosophila CYP4G enzymes. Kefi M, et al. Insect Biochem Mol Biol, 2024 Jan. PMID 38008364
    2. Origin and evolution of the CYP4G subfamily in insects, cytochrome P450 enzymes involved in cuticular hydrocarbon synthesis. Feyereisen R. Mol Phylogenet Evol, 2020 Feb. PMID 31805344
    3. A new cytochrome P450 from Drosophila melanogaster, CYP4G15, expressed in the nervous system. Maïbèche-Coisne M, et al. Biochem Biophys Res Commun, 2000 Jul 14. PMID 10891384
    4. On the genomic location of the exuperantia1 gene in Drosophila miranda: the limits of in situ hybridization experiments. Bachtrog D, et al. Genetics, 2003 Jul. PMID 12871928, Free PMC Article
    5. Systemic and local cues drive neural stem cell niche remodelling during neurogenesis in Drosophila. Spéder P, et al. Elife, 2018 Jan 4. PMID 29299997, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4g15
    Names
    CG11715-PA
    CG11715-PC
    Cyp4g15-PA
    Cyp4g15-PC
    cytochrome P450
    NP_572721.1
    NP_727531.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11477058..11483233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167287.2 → NP_727531.2  cytochrome P450 4g15, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727531.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VYY4
      UniProtKB/TrEMBL
      Q8IR88
      Conserved Domains (1) summary
      pfam00067
      Location:47 → 542
      p450; Cytochrome P450

    2. NM_132493.3 → NP_572721.1  cytochrome P450 4g15, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572721.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VYY4
      UniProtKB/TrEMBL
      Q8IR88
      Related
      FBpp0073352
      Conserved Domains (1) summary
      pfam00067
      Location:47 → 542
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IR88 Q8IR88
    Q9VYY4.1 Q9VYY4

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