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    Aven Apoptosis and caspase activation inhibitor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32215, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Avenprovided by FlyBase
    Official Full Name
    Apoptosis and caspase activation inhibitorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030410
    Locus tag
    Dmel_CG15727
    See related
    AllianceGenome:FB:FBgn0030410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15727; dAven; Dmel\CG15727
    Summary
    Involved in negative regulation of G2/M transition of mitotic cell cycle. Located in cytosol and nucleus. Is expressed in several structures, including embryonic/larval salivary gland; epithelium; germ layer; larval tracheal system; and larval ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Aven in Genome Data Viewer
    Location:
    11B5-11B5; 1-39 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12628370..12629640, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12522403..12523673, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44568 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tomosyn Neighboring gene mir-970 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of dAven, a Drosophila melanogaster ortholog of the cell cycle regulator Aven. Zou S, et al. Cell Cycle, 2011 Mar 15. PMID 21368576, Free PMC Article
    2. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article
    3. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article
    4. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Neely GG, et al. Cell, 2010 Nov 12. PMID 21074052, Free PMC Article
    5. Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Schnorrer F, et al. Nature, 2010 Mar 11. PMID 20220848

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    apoptosis and caspase activation inhibitor
    Names
    Aven-PA
    Aven-PB
    CG15727-PA
    CG15727-PB
    aven ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12628370..12629640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298233.1 → NP_001285162.1  apoptosis and caspase activation inhibitor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285162.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYK8
      Conserved Domains (1) summary
      PRK12278
      Location:180 → 248
      PRK12278; 50S ribosomal protein L21/unknown domain fusion protein; Provisional

    2. NM_132589.2 → NP_572817.1  apoptosis and caspase activation inhibitor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572817.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYK8
      Related
      FBpp0073542, FBtr0073709
      Conserved Domains (1) summary
      PRK12278
      Location:180 → 248
      PRK12278; 50S ribosomal protein L21/unknown domain fusion protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYK8 Q9VYK8

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