dffb DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: dffbprovided by Xenbase
Official Full Name: DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)provided by Xenbase
Primary source: Xenbase:XB-GENE-990152
See related: Ensembl:ENSXETG00000006035 AllianceGenome:Xenbase:XB-GENE-990152
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary: Predicted to enable DNA nuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytoplasm and nucleus. Orthologous to human DFFB (DNA fragmentation factor subunit beta). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	7	NC_030683.2 (96871897..96881104)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	7	NC_030683.1 (75938882..75950439, complement)

Chromosome 7 - NC_030683.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA endonuclease activity	IEA Inferred from Electronic Annotation more info
enables DNA nuclease activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic DNA fragmentation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within apoptotic DNA fragmentation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA fragmentation factor subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127164.1 → NP_001120636.1 DNA fragmentation factor subunit beta

See identical proteins and their annotated locations for NP_001120636.1

Status: PROVISIONAL

Source sequence(s)

BC161794

UniProtKB/TrEMBL

B1WBL0, F7EHJ0

Related

ENSXETP00000013293.4, ENSXETT00000013293.4

Conserved Domains (2) summary

cd06535
Location:11 → 87

CIDE_N_CAD; CIDE_N domain of CAD nuclease. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are ...

pfam09230
Location:107 → 330

DFF40; DNA fragmentation factor 40 kDa