azin1b antizyme inhibitor 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: azin1bprovided by ZNC
Official Full Name: antizyme inhibitor 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030121-1
See related: Ensembl:ENSDARG00000035869 AllianceGenome:ZFIN:ZDB-GENE-030121-1
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: azin1; oazin; wu:fj32d12
Summary: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes one of two copies of antizyme inhibitor 1 in zebrafish. It is expressed in embryos and adult fish and may have a role in zebrafish development. [provided by RefSeq, May 2015]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (32930476..32944035, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (33343356..33356915, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables ornithine decarboxylase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine decarboxylase activator activity	IEA Inferred from Electronic Annotation more info
enables ornithine decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within polyamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of polyamine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in putrescine biosynthetic process from ornithine	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: antizyme inhibitor 1b

Names: antizyme inhibitor 1; ornithine decarboxylase antizyme inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007159.2 → NP_001007160.2 antizyme inhibitor 1b

Status: REVIEWED

Source sequence(s)

AL807244, BI884235, EH554389, EH575502

UniProtKB/TrEMBL

A0A8M1N338, Q801V3

Related

ENSDARP00000122392.1, ENSDART00000137611.3

Conserved Domains (2) summary

TIGR03099
Location:40 → 395

dCO2ase_PEP1; pyridoxal-dependent decarboxylase, exosortase A system-associated

cd06831
Location:26 → 419

PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor