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    nsd2 nuclear receptor binding SET domain protein 2 [ Pangasianodon hypophthalmus (striped catfish) ]

    Gene ID: 113545431, updated on 15-Mar-2024

    Summary

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    Gene symbol
    nsd2
    Gene description
    nuclear receptor binding SET domain protein 2
    Locus tag
    PHYPO_G00180450
    See related
    EnsemblRapid:ENSPHYG00025011122
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pangasianodon hypophthalmus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes; Pangasiidae; Pangasianodon
    Orthologs
    zebrafish all
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    Genomic context

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    See nsd2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2023_02 current fPanHyp1.pri (GCF_027358585.1) 3 NC_069712.1 (20397669..20419489)

    Chromosome 3 - NC_069712.1Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor receptor 3 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 1 Neighboring gene uncharacterized LOC128318013 Neighboring gene KIAA1109 ortholog Neighboring gene C9orf72-SMCR8 complex subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_069712.1 Chromosome 3 Reference fPanHyp1.pri

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables histone H3K36 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase NSD2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_027358585.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference fPanHyp1.pri

    Genomic

    1. NC_069712.1 Reference fPanHyp1.pri

      Range
      20397669..20419489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_026944793.3 → XP_026800594.2  histone-lysine N-methyltransferase NSD2 isoform X3

      UniProtKB/TrEMBL
      A0A5N5PQA6
      Related
      ENSPHYP00025025777.1, ENSPHYT00025027846.1
      Conserved Domains (7) summary
      cd05838
      Location:973 → 1066
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      cd15660
      Location:1333 → 1375
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1156 → 1297
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17907
      Location:1116 → 1154
      AWS; AWS domain
      pfam17982
      Location:1374 → 1419
      C5HCH; NSD Cys-His rich domain
      cl02554
      Location:279 → 393
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
      cl22851
      Location:858 → 911
      PHD_SF; PHD finger superfamily

    2. XM_026944785.3 → XP_026800586.2  histone-lysine N-methyltransferase NSD2 isoform X1

      UniProtKB/TrEMBL
      A0A5N5PQA6
      Related
      ENSPHYP00025025757.1, ENSPHYT00025027826.1
      Conserved Domains (7) summary
      cd05838
      Location:991 → 1084
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      cd15660
      Location:1351 → 1393
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1174 → 1315
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17907
      Location:1134 → 1172
      AWS; AWS domain
      pfam17982
      Location:1392 → 1437
      C5HCH; NSD Cys-His rich domain
      cl02554
      Location:297 → 411
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
      cl22851
      Location:876 → 929
      PHD_SF; PHD finger superfamily

    3. XM_034303066.2 → XP_034158957.1  histone-lysine N-methyltransferase NSD2 isoform X2

      UniProtKB/TrEMBL
      A0A5N5PQA6
      Conserved Domains (7) summary
      cd05838
      Location:990 → 1083
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      cd15660
      Location:1350 → 1392
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1173 → 1314
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17907
      Location:1133 → 1171
      AWS; AWS domain
      pfam17982
      Location:1391 → 1436
      C5HCH; NSD Cys-His rich domain
      cl02554
      Location:297 → 411
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
      cl22851
      Location:875 → 928
      PHD_SF; PHD finger superfamily

    4. XM_026944803.3 → XP_026800604.2  histone-lysine N-methyltransferase NSD2 isoform X3

      UniProtKB/TrEMBL
      A0A5N5PQA6
      Conserved Domains (7) summary
      cd05838
      Location:973 → 1066
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      cd15660
      Location:1333 → 1375
      PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
      cd19211
      Location:1156 → 1297
      SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
      pfam17907
      Location:1116 → 1154
      AWS; AWS domain
      pfam17982
      Location:1374 → 1419
      C5HCH; NSD Cys-His rich domain
      cl02554
      Location:279 → 393
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
      cl22851
      Location:858 → 911
      PHD_SF; PHD finger superfamily
    Nucleotide Protein
    Heading Accession and Version

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