U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Nucleotidyltransferase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819170, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Full Name
    Nucleotidyltransferase family protein
    Primary source
    TAIR:AT2G45620
    Locus tag
    AT2G45620
    See related
    Araport:AT2G45620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F17K2.15; URT1; UTP:RNA uridylyltransferase 1
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (18792864..18795904)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene D-isomer specific 2-hydroxyacid dehydrogenase family protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular mechanism underlying the di-uridylation activity of Arabidopsis TUTase URT1. Hu Q, et al. Nucleic Acids Res, 2022 Oct 14. PMID 36177876, Free PMC Article
    2. Crystal structure of Arabidopsis terminal uridylyl transferase URT1. Zhu L, et al. Biochem Biophys Res Commun, 2020 Apr 2. PMID 32008746
    3. Uridylation prevents 3' trimming of oligoadenylated mRNAs. Sement FM, et al. Nucleic Acids Res, 2013 Aug. PMID 23748567, Free PMC Article
    4. The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis. Scheer H, et al. Nat Commun, 2021 Feb 26. PMID 33637717, Free PMC Article
    5. Uridylation and PABP Cooperate to Repair mRNA Deadenylated Ends in Arabidopsis. Zuber H, et al. Cell Rep, 2016 Mar 22. PMID 26972004

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular mechanism underlying the di-uridylation activity of Arabidopsis TUTase URT1.
      Title: Molecular mechanism underlying the di-uridylation activity of Arabidopsis TUTase URT1.
    2. The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis.
      Title: The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis.
    3. Crystal structure of Arabidopsis terminal uridylyl transferase URT1.
      Title: Crystal structure of Arabidopsis terminal uridylyl transferase URT1.
    4. role in RNA metabolism and silencing
      Title: A genetics screen highlights emerging roles for CPL3, RST1 and URT1 in RNA metabolism and silencing.
    5. URT1 uridylates deadenylated mRNAs and prevents excessive deadenylation.
      Title: Uridylation prevents 3' trimming of oligoadenylated mRNAs.
    6. Results uncover a role for uridylation and PABP in repairing mRNA deadenylated ends and reveal that uridylation plays diverse roles in eukaryotic mRNA metabolism.
      Title: Uridylation and PABP Cooperate to Repair mRNA Deadenylated Ends in Arabidopsis.
    7. UTP: RNA uridylyltransferase (URT1) is a functional paralog of HESO1. URT1 interacts with AGO1 and plays a predominant role in miRNA uridylation when HESO1 is absent. [URT1]
      Title: Synergistic and independent actions of multiple terminal nucleotidyl transferases in the 3' tailing of small RNAs in Arabidopsis.
    8. URT1 and HESO1 prefer substrates with different 3' end nucleotides in vitro and act cooperatively to tail different forms of the same miRNAs in vivo. Moreover, both HESO1 and URT1 exhibit nucleotidyl transferase activity on AGO1-bound miRNAs. [URT1]
      Title: Distinct and cooperative activities of HESO1 and URT1 nucleotidyl transferases in microRNA turnover in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_130124.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA uridylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA 3' uridylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in RNA 3' uridylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in miRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of post-transcriptional gene silencing by regulatory ncRNA IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within nuclear-transcribed mRNA poly(A) tail shortening IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Nucleotidyltransferase family protein
    NP_566048.1
    • Nucleotidyltransferase family protein; FUNCTIONS IN: nucleotidyltransferase activity; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Nucleotidyl transferase domain (InterPro:IPR002934), PAP/25A-associated (InterPro:IPR002058); BEST Arabidopsis thaliana protein match is: Nucleotidyltransferase family protein (TAIR:AT3G45750.1); Has 1962 Blast hits to 1846 proteins in 232 species: Archae - 0; Bacteria - 9; Metazoa - 921; Fungi - 372; Plants - 185; Viruses - 0; Other Eukaryotes - 475 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18792864..18795904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130124.1 → NP_566048.1  Nucleotidyltransferase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566048.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64642, Q9C5K9
      UniProtKB/TrEMBL
      A0A5S9X7J0, A0A654F3F9
      Conserved Domains (2) summary
      cd05402
      Location:456 → 566
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:655 → 714
      PAP_assoc; Cid1 family poly A polymerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O64642.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools