ARP4 actin-related protein 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: ARP4
Official Full Name: actin-related protein 4
Primary source: TAIR:AT1G18450
Locus tag: AT1G18450
See related: Araport:AT1G18450
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: actin-related protein 4; ATARP4; F15H18.8; F15H18_8
Summary: Encodes a gene similar to actin-related proteins in other organisms. Member of nuclear ARP family of genes. Component of chromatin remodeling complexes, involved in chromatin-mediated gene regulation. Phenotype of the arp4-1 mutant allele revealed partial sterility due to defects in anther development. Targeting the distinct, 3' UTR of AtARP4 transcripts with RNA interference caused a drastic reduction in the level of AtARP4 protein expression, and resulted in strong pleiotropic phenotypes such as altered organization of plant organs, early flowering, delayed flower senescence and high levels of sterility. Western blot analysis and immunolabelling demonstrated a clear correlation between reductions in the level of AtARP4 expression and severity of the phenotypes.
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Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

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Actin-Related Protein 4 Interacts with PIE1 and Regulates Gene Expression in Arabidopsis.
Title: Actin-Related Protein 4 Interacts with PIE1 and Regulates Gene Expression in Arabidopsis.
The effects of antibody silencing of ARP4 on growth and flowering in transgenic and wild type A. thaliana, Brassica, and tobacco.
Title: Silencing the nuclear actin-related protein AtARP4 in Arabidopsis has multiple effects on plant development, including early flowering and delayed floral senescence.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_101702.4

Function	Evidence Code	Pubs
enables structural constituent of cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within long-day photoperiodism, flowering	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen sperm cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Ino80 complex	IDA Inferred from Direct Assay more info	PubMed
part_of NuA4 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Swr1 complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in nucleolus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

NP_564051.1

actin-related protein 4 (ARP4); FUNCTIONS IN: structural constituent of cytoskeleton; INVOLVED IN: long-day photoperiodism, flowering, chromatin organization, pollen sperm cell differentiation; LOCATED IN: nucleolus, nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Actin/actin-like (InterPro:IPR004000); BEST Arabidopsis thaliana protein match is: actin-11 (TAIR:AT3G12110.1); Has 13669 Blast hits to 13362 proteins in 2792 species: Archae - 2; Bacteria - 480; Metazoa - 5593; Fungi - 3430; Plants - 1457; Viruses - 2; Other Eukaryotes - 2705 (source: NCBI BLink).

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The following sections contain reference sequences that belong to a specific genome build. Explain