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    ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 [ Melopsittacus undulatus (budgerigar) ]

    Gene ID: 115947053, updated on 8-Nov-2024

    Summary

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    Gene symbol
    ARHGEF2
    Gene description
    Rho/Rac guanine nucleotide exchange factor 2
    See related
    Ensembl:ENSMUNG00015011459
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Melopsittacus undulatus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves; Psittaciformes; Psittaculidae; Melopsittacus
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGEF2 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_11 current bMelUnd1.mat.Z (GCF_012275295.1) 20 NC_047546.1 (1865595..1883519)

    Chromosome 20 - NC_047546.1Genomic Context describing neighboring genes Neighboring gene natriuretic peptide receptor 1 Neighboring gene transfer RNA methionine (anticodon CAU) Neighboring gene ankyrin repeat domain 35 Neighboring gene protein inhibitor of activated STAT 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_047546.1 Chromosome 20 Reference bMelUnd1.mat.Z

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_012275295.1-RS_2024_11

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bMelUnd1.mat.Z

    Genomic

    1. NC_047546.1 Reference bMelUnd1.mat.Z

      Range
      1865595..1883519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_034071211.1 → XP_033927102.1  rho guanine nucleotide exchange factor 2 isoform X5

      UniProtKB/TrEMBL
      A0A8V5GPS6
      Conserved Domains (3) summary
      cd00160
      Location:224 → 418
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd20877
      Location:22 → 82
      C1_ARHGEF2; protein kinase C conserved region 1 (C1 domain) found in Rho guanine nucleotide exchange factor 2 (ARHGEF2) and similar proteins
      cl17171
      Location:461 → 576
      PH-like; Pleckstrin homology-like domain

    2. XM_034071208.1 → XP_033927099.1  rho guanine nucleotide exchange factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V5GPS6
      Conserved Domains (3) summary
      cd00160
      Location:224 → 418
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd20877
      Location:22 → 82
      C1_ARHGEF2; protein kinase C conserved region 1 (C1 domain) found in Rho guanine nucleotide exchange factor 2 (ARHGEF2) and similar proteins
      cl17171
      Location:461 → 576
      PH-like; Pleckstrin homology-like domain

    3. XM_034071207.1 → XP_033927098.1  rho guanine nucleotide exchange factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V5GPS6
      Conserved Domains (3) summary
      cd00160
      Location:234 → 428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd20877
      Location:32 → 92
      C1_ARHGEF2; protein kinase C conserved region 1 (C1 domain) found in Rho guanine nucleotide exchange factor 2 (ARHGEF2) and similar proteins
      cl17171
      Location:471 → 586
      PH-like; Pleckstrin homology-like domain

    4. XM_034071210.1 → XP_033927101.1  rho guanine nucleotide exchange factor 2 isoform X4

      UniProtKB/TrEMBL
      A0A8V5GPS6
      Conserved Domains (3) summary
      cd00160
      Location:212 → 406
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd20877
      Location:10 → 70
      C1_ARHGEF2; protein kinase C conserved region 1 (C1 domain) found in Rho guanine nucleotide exchange factor 2 (ARHGEF2) and similar proteins
      cl17171
      Location:449 → 564
      PH-like; Pleckstrin homology-like domain

    5. XM_034071209.1 → XP_033927100.1  rho guanine nucleotide exchange factor 2 isoform X4

      UniProtKB/TrEMBL
      A0A8V5GPS6
      Related
      ENSMUNP00015015545.1, ENSMUNT00015016392.1
      Conserved Domains (3) summary
      cd00160
      Location:212 → 406
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd20877
      Location:10 → 70
      C1_ARHGEF2; protein kinase C conserved region 1 (C1 domain) found in Rho guanine nucleotide exchange factor 2 (ARHGEF2) and similar proteins
      cl17171
      Location:449 → 564
      PH-like; Pleckstrin homology-like domain

    6. XM_034071206.1 → XP_033927097.1  rho guanine nucleotide exchange factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V5GPS6
      Conserved Domains (3) summary
      cd00160
      Location:293 → 487
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd20877
      Location:91 → 151
      C1_ARHGEF2; protein kinase C conserved region 1 (C1 domain) found in Rho guanine nucleotide exchange factor 2 (ARHGEF2) and similar proteins
      cl17171
      Location:530 → 645
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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