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    lgc-58 Ligand-Gated ion Channel [ Caenorhabditis elegans ]

    Gene ID: 191637, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lgc-58
    Official Full Name
    Ligand-Gated ion Channel
    Primary source
    WormBase:WBGene00001587
    Locus tag
    CELE_C45B2.4
    See related
    AllianceGenome:WB:WBGene00001587
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane and postsynapse. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in nerve ring and neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lgc-58 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    15
    Sequence:
    Chromosome: X; NC_003284.9 (6075509..6081881)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Neuropeptide-Like Protein Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Novel and Functionally Diverse Class of Acetylcholine-Gated Ion Channels. Hardege I, et al. J Neurosci, 2023 Feb 15. PMID 36604172, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ligand-Gated ion Channel
    NP_001024472.2
    • Confirmed by transcript evidence;
      Product from WormBase gene class lgc
    NP_001367470.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class lgc
    NP_001368736.1
    • Partially confirmed by transcript evidence;
      Product from WormBase gene class lgc
    NP_001368737.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class lgc
    NP_001368738.1
    • Partially confirmed by transcript evidence;
      Product from WormBase gene class lgc
    NP_001368739.1
    • Partially confirmed by transcript evidence;
      Product from WormBase gene class lgc
    NP_001368740.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class lgc
    NP_001368741.1
    • Partially confirmed by transcript evidence;
      Product from WormBase gene class lgc
    NP_001368742.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class lgc
    NP_001368743.1
    • Partially confirmed by transcript evidence;
      Product from WormBase gene class lgc
    NP_001368744.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class lgc
    NP_001368745.1
    • Partially confirmed by transcript evidence;
      Product from WormBase gene class lgc
    NP_001368746.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class lgc

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6075509..6081881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029301.7 → NP_001024472.2  Ligand-Gated ion Channel [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024472.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2WF65
      Conserved Domains (3) summary
      TIGR00860
      Location:30 → 541
      LIC; Cation transporter family protein
      pfam02931
      Location:41 → 237
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:245 → 538
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    2. NM_001380998.2 → NP_001368746.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKP2
      Conserved Domains (1) summary
      TIGR00860
      Location:30 → 502
      LIC; Cation transporter family protein

    3. NM_001380992.2 → NP_001368740.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKB1
      Conserved Domains (1) summary
      TIGR00860
      Location:30 → 513
      LIC; Cation transporter family protein

    4. NM_001380988.1 → NP_001368738.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IN81
      Conserved Domains (1) summary
      TIGR00860
      Location:30 → 548
      LIC; Cation transporter family protein

    5. NM_001380989.1 → NP_001368736.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKM8
      Conserved Domains (1) summary
      TIGR00860
      Location:30 → 535
      LIC; Cation transporter family protein

    6. NM_001380990.1 → NP_001368737.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0INF0
      Conserved Domains (1) summary
      TIGR00860
      Location:30 → 528
      LIC; Cation transporter family protein

    7. NM_001380991.1 → NP_001368739.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V6M3Y9
      Conserved Domains (1) summary
      TIGR00860
      Location:30 → 520
      LIC; Cation transporter family protein

    8. NM_001380993.1 → NP_001368743.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0ILX4
      Conserved Domains (1) summary
      TIGR00860
      Location:30 → 537
      LIC; Cation transporter family protein

    9. NM_001380994.1 → NP_001368744.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IK93
      Conserved Domains (1) summary
      TIGR00860
      Location:30 → 530
      LIC; Cation transporter family protein

    10. NM_001380995.1 → NP_001368741.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IJ32
      Conserved Domains (1) summary
      TIGR00860
      Location:30 → 524
      LIC; Cation transporter family protein

    11. NM_001380996.1 → NP_001368742.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0ILI0
      Conserved Domains (1) summary
      TIGR00860
      Location:30 → 517
      LIC; Cation transporter family protein

    12. NM_001380997.1 → NP_001368745.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IK64
      Conserved Domains (1) summary
      TIGR00860
      Location:30 → 509
      LIC; Cation transporter family protein

    13. NM_001380999.1 → NP_001367470.1  Ligand-Gated ion Channel [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYL4
      Conserved Domains (1) summary
      TIGR00860
      Location:30 → 423
      LIC; Cation transporter family protein
    Nucleotide Protein
    Heading Accession and Version

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