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    Pigt phosphatidylinositol glycan anchor biosynthesis, class T [ Mus musculus (house mouse) ]

    Gene ID: 78928, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pigtprovided by MGI
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Tprovided by MGI
    Primary source
    MGI:MGI:1926178
    See related
    Ensembl:ENSMUSG00000017721 AllianceGenome:MGI:1926178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NDAP; Ndap7; CGI-06; 2510012P17Rik; 4930534E15Rik
    Summary
    Involved in attachment of GPI anchor to protein. Acts upstream of or within neuron apoptotic process and neuron differentiation. Located in cytoplasmic vesicle. Part of GPI-anchor transamidase complex. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 3 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGT (phosphatidylinositol glycan anchor biosynthesis class T). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 132.8), adrenal adult (RPKM 118.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pigt in Genome Data Viewer
    Location:
    2 H3; 2 85.17 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164339461..164350221)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164497090..164508301)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06326 Neighboring gene syndecan 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164266728-164266915 Neighboring gene STARR-seq mESC enhancer starr_06330 Neighboring gene STARR-positive B cell enhancer ABC_E7884 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164286295-164286478 Neighboring gene SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae) Neighboring gene transformation related protein 53 target 5 Neighboring gene dysbindin domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E9539 Neighboring gene STARR-seq mESC enhancer starr_06331 Neighboring gene predicted gene, 36090 Neighboring gene STARR-seq mESC enhancer starr_06332 Neighboring gene predicted gene 14317

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and identification of differentially expressed transcripts in primary culture of GABAergic neurons. Li Z, et al. Neurochem Res, 2001 Oct. PMID 11700951
    2. The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis. Li HL, et al. FEBS Lett, 2006 Mar 20. PMID 16516892
    3. PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8. Ohishi K, et al. EMBO J, 2001 Aug 1. PMID 11483512, Free PMC Article
    4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    5. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in attachment of GPI anchor to protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of GPI anchor to protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GPI-anchor transamidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GPI-anchor transamidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of GPI-anchor transamidase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GPI transamidase component PIG-T
    Names
    neuronal development-associated protein 7
    phosphatidylinositol-glycan biosynthesis class T protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362644.2 → NP_001349573.1  GPI transamidase component PIG-T isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL591478
      Consensus CDS
      CCDS89578.1
      UniProtKB/TrEMBL
      B7ZC19
      Related
      ENSMUSP00000112577.2, ENSMUST00000117066.8
      Conserved Domains (1) summary
      pfam04113
      Location:36 → 419
      Gpi16; Gpi16 subunit, GPI transamidase component

    2. NM_001362645.2 → NP_001349574.1  GPI transamidase component PIG-T isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL591478
      Conserved Domains (1) summary
      pfam04113
      Location:2 → 301
      Gpi16; Gpi16 subunit, GPI transamidase component

    3. NM_001378795.1 → NP_001365724.1  GPI transamidase component PIG-T isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL591478
      Conserved Domains (1) summary
      pfam04113
      Location:71 → 478
      Gpi16; Gpi16 subunit, GPI transamidase component

    4. NM_133779.3 → NP_598540.2  GPI transamidase component PIG-T isoform 1 precursor

      See identical proteins and their annotated locations for NP_598540.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL591478
      Consensus CDS
      CCDS17038.2
      UniProtKB/Swiss-Prot
      A2A5G2, Q3U2X2, Q8BXQ2, Q99JA3
      UniProtKB/TrEMBL
      Q3U5R2
      Related
      ENSMUSP00000099390.5, ENSMUST00000103101.11
      Conserved Domains (1) summary
      pfam04113
      Location:36 → 572
      Gpi16; Gpi16 subunit, GPI transamidase component

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164339461..164350221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001407281.1: Suppressed sequence

      Description
      NM_001407281.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BXQ2.2 GenPept UniProtKB/Swiss-Prot:Q8BXQ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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