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    Brms1 breast cancer metastasis-suppressor 1 [ Mus musculus (house mouse) ]

    Gene ID: 107392, updated on 27-Nov-2024

    Summary

    Official Symbol
    Brms1provided by MGI
    Official Full Name
    breast cancer metastasis-suppressor 1provided by MGI
    Primary source
    MGI:MGI:2388804
    See related
    Ensembl:ENSMUSG00000080268 AllianceGenome:MGI:2388804
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable NF-kappaB binding activity and histone deacetylase binding activity. Predicted to be involved in positive regulation of anoikis; positive regulation of protein deacetylation; and regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Predicted to be part of Sin3-type complex. Is expressed in alimentary system; central nervous system; genitourinary system; heart; and respiratory system. Orthologous to human BRMS1 (BRMS1 transcriptional repressor and anoikis regulator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 61.2), stomach adult (RPKM 31.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Brms1 in Genome Data Viewer
    Location:
    19 A; 19 4.23 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5091391..5099940)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5041363..5049912)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30581 Neighboring gene nuclear encoded tRNA serine 6 (anticodon GCT) Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5041192-5041379 Neighboring gene beta-1,4-glucuronyltransferase 1 Neighboring gene Ras and Rab interactor 1 Neighboring gene CD248 antigen, endosialin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: B4gat1

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NF-kappaB binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell migration NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of anoikis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Sin3-type complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    breast cancer metastasis-suppressor 1 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374047.1NP_001360976.1  breast cancer metastasis-suppressor 1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124502
      UniProtKB/Swiss-Prot
      Q99N20
      UniProtKB/TrEMBL
      Q547N0, Q8R5H5
      Conserved Domains (1) summary
      pfam08598
      Location:60178
      Sds3; Sds3-like
    2. NM_001374048.1NP_001360977.1  breast cancer metastasis-suppressor 1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124502
      UniProtKB/TrEMBL
      Q8R5H5
      Conserved Domains (1) summary
      pfam08598
      Location:60178
      Sds3; Sds3-like
    3. NM_134155.3NP_598916.1  breast cancer metastasis-suppressor 1 homolog isoform 1

      See identical proteins and their annotated locations for NP_598916.1

      Status: VALIDATED

      Source sequence(s)
      AC124502
      Consensus CDS
      CCDS50355.1
      UniProtKB/Swiss-Prot
      Q99N20
      UniProtKB/TrEMBL
      Q547N0, Q8R5H5
      Related
      ENSMUSP00000112266.3, ENSMUST00000116567.4
      Conserved Domains (1) summary
      pfam08598
      Location:60178
      Sds3; Sds3-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5091391..5099940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)