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    MKRN2OS MKRN2 opposite strand [ Homo sapiens (human) ]

    Gene ID: 100129480, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MKRN2OSprovided by HGNC
    Official Full Name
    MKRN2 opposite strandprovided by HGNC
    Primary source
    HGNC:HGNC:40375
    See related
    Ensembl:ENSG00000225526 AllianceGenome:HGNC:40375
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C3orf83; MKRN2-AS1
    Expression
    Broad expression in small intestine (RPKM 1.1), duodenum (RPKM 1.1) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MKRN2OS in Genome Data Viewer
    Location:
    3p25.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (12539776..12560999, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (12537578..12558803, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (12581275..12602498, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:12558643-12559143 Neighboring gene RNA, 5S ribosomal pseudogene 123 Neighboring gene RNA, U6 small nuclear 377, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14065 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12598813-12599336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19446 Neighboring gene makorin ring finger protein 2 Neighboring gene MPRA-validated peak4543 silencer Neighboring gene Raf-1 proto-oncogene, serine/threonine kinase Neighboring gene small nucleolar RNA U13 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:12684584-12684794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19447 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12698025-12698668 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12704698-12705308 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12705309-12705920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19449 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12711892-12712473 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12712474-12713054 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12715375-12716244 Neighboring gene cysteine rich protein 1 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The DNA sequence, annotation and analysis of human chromosome 3. Muzny DM, et al. Nature, 2006 Apr 27. PMID 16641997
    2. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Choudhury NR, et al. BMC Biol, 2017 Nov 8. PMID 29117863, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    MKRN2 opposite strand protein
    Names
    MKRN2 antisense RNA 1 (non-protein coding)
    MKRN2 antisense gene protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195279.2 → NP_001182208.1  MKRN2 opposite strand protein isoform 1

      See identical proteins and their annotated locations for NP_001182208.1

      Status: VALIDATED

      Source sequence(s)
      AC018500
      Consensus CDS
      CCDS58816.1
      UniProtKB/Swiss-Prot
      H3BPM6
      Related
      ENSP00000455385.3, ENST00000564146.4
      Conserved Domains (1) summary
      pfam16044
      Location:8 → 199
      DUF4796; Domain of unknown function (DUF4796)

    2. NM_001378007.1 → NP_001364936.1  MKRN2 opposite strand protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC018500
      Conserved Domains (1) summary
      pfam16044
      Location:1 → 80
      DUF4796; Domain of unknown function (DUF4796)

    3. NM_001378008.1 → NP_001364937.1  MKRN2 opposite strand protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC018500
      Conserved Domains (1) summary
      pfam16044
      Location:1 → 80
      DUF4796; Domain of unknown function (DUF4796)

    4. NM_001378009.1 → NP_001364938.1  MKRN2 opposite strand protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC018500
      Conserved Domains (1) summary
      pfam16044
      Location:1 → 80
      DUF4796; Domain of unknown function (DUF4796)

    5. NM_001378010.1 → NP_001364939.1  MKRN2 opposite strand protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC018500
      Conserved Domains (1) summary
      pfam16044
      Location:20 → 129
      DUF4796; Domain of unknown function (DUF4796)

    6. NM_001378011.1 → NP_001364940.1  MKRN2 opposite strand protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC018500
      Conserved Domains (1) summary
      pfam16044
      Location:8 → 176
      DUF4796; Domain of unknown function (DUF4796)

    RNA

    1. NR_165360.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC018500

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      12539776..12560999 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533242.4 → XP_011531544.1  MKRN2 opposite strand protein isoform X1

      See identical proteins and their annotated locations for XP_011531544.1

      Conserved Domains (1) summary
      pfam16044
      Location:1 → 80
      DUF4796; Domain of unknown function (DUF4796)

    2. XM_011533243.4 → XP_011531545.1  MKRN2 opposite strand protein isoform X1

      See identical proteins and their annotated locations for XP_011531545.1

      Conserved Domains (1) summary
      pfam16044
      Location:1 → 80
      DUF4796; Domain of unknown function (DUF4796)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      12537578..12558803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344805.1 → XP_054200780.1  MKRN2 opposite strand protein isoform X1

    2. XM_054344806.1 → XP_054200781.1  MKRN2 opposite strand protein isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H3BPM6.1 GenPept UniProtKB/Swiss-Prot:H3BPM6

    Gene LinkOut

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