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    CALCA calcitonin related polypeptide alpha [ Homo sapiens (human) ]

    Gene ID: 796, updated on 27-Nov-2024

    Summary

    Official Symbol
    CALCAprovided by HGNC
    Official Full Name
    calcitonin related polypeptide alphaprovided by HGNC
    Primary source
    HGNC:HGNC:1437
    See related
    Ensembl:ENSG00000110680 MIM:114130; AllianceGenome:HGNC:1437
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I; CGRP-alpha
    Summary
    This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
    Expression
    Restricted expression toward thyroid (RPKM 13.7) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CALCA in Genome Data Viewer
    Location:
    11p15.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (14966668..14972351, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (15063025..15068708, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (14988214..14993897, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 3B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4477 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:14929307-14929806 Neighboring gene cytochrome P450 family 2 subfamily R member 1 Neighboring gene calcitonin pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:14993078-14993724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3175 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:14996341-14996870 Neighboring gene Sharpr-MPRA regulatory region 7615 Neighboring gene olfactory receptor family 7 subfamily E member 41 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:15096041-15096542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3176 Neighboring gene calcitonin related polypeptide beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126648

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcitonin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcitonin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in amylin receptor 1 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in amylin receptor 2 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antibacterial humoral response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antifungal humoral response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcitonin family receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in calcitonin gene-related peptide receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to nerve growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to Gram-negative bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in detection of temperature stimulus involved in sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryo implantation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in feeding behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in leukocyte cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in monocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of bone resorption IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of calcium ion transport into cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of ossification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within nervous system process involved in regulation of systemic arterial blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ossification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-1 alpha production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-8 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of macrophage differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of blood pressure NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to heat IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to pain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to yeast IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vasculature development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vasodilation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in hippocampal mossy fiber to CA3 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal dense core vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in terminal bouton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    calcitonin; calcitonin gene-related peptide 1
    Names
    alpha-type CGRP
    calcitonin 1
    calcitonin gene-related peptide I
    calcitonin/calcitonin-related polypeptide, alpha
    katacalcin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015960.1 RefSeqGene

      Range
      5001..10618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_13

    mRNA and Protein(s)

    1. NM_001033952.3NP_001029124.1  calcitonin isoform CT preproprotein

      See identical proteins and their annotated locations for NP_001029124.1

      Status: REVIEWED

      Source sequence(s)
      AC090835, FO082042
      Consensus CDS
      CCDS7819.1
      UniProtKB/Swiss-Prot
      B7ZL39, P01258, Q13935, Q13937, Q52LX7
      Related
      ENSP00000379657.2, ENST00000396372.2
      Conserved Domains (1) summary
      pfam00214
      Location:1121
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
    2. NM_001033953.3NP_001029125.1  calcitonin gene-related peptide 1 isoform alpha-CGRP preproprotein

      See identical proteins and their annotated locations for NP_001029125.1

      Status: REVIEWED

      Source sequence(s)
      AC090835, FO082042
      Consensus CDS
      CCDS31432.1
      UniProtKB/Swiss-Prot
      P06881, Q93048, Q9UCP0
      Related
      ENSP00000417833.1, ENST00000486207.6
      Conserved Domains (1) summary
      pfam00214
      Location:1124
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
    3. NM_001378949.1NP_001365878.1  calcitonin isoform CT preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC090835, FO082042
      Consensus CDS
      CCDS7819.1
      UniProtKB/Swiss-Prot
      B7ZL39, P01258, Q13935, Q13937, Q52LX7
      Conserved Domains (1) summary
      pfam00214
      Location:1121
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
    4. NM_001378950.1NP_001365879.1  calcitonin isoform alpha-CGRP preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC090835, FO082042
      Consensus CDS
      CCDS31432.1
      UniProtKB/Swiss-Prot
      P06881, Q93048, Q9UCP0
      Related
      ENSP00000516203.1, ENST00000706042.1
      Conserved Domains (1) summary
      pfam00214
      Location:1124
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
    5. NM_001741.3NP_001732.1  calcitonin isoform CT preproprotein

      See identical proteins and their annotated locations for NP_001732.1

      Status: REVIEWED

      Source sequence(s)
      AC090835, BC069704, BF942024
      Consensus CDS
      CCDS7819.1
      UniProtKB/Swiss-Prot
      B7ZL39, P01258, Q13935, Q13937, Q52LX7
      Related
      ENSP00000331746.4, ENST00000331587.9
      Conserved Domains (1) summary
      pfam00214
      Location:1121
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    RNA

    1. NR_125898.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090835, BC069684, BX094781, CB048118, M64486
    2. NR_166196.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090835, FO082042

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      14966668..14972351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      15063025..15068708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369928.1XP_054225903.1  calcitonin isoform X1

      UniProtKB/Swiss-Prot
      B7ZL39, P01258, Q13935, Q13937, Q52LX7
    2. XM_054369929.1XP_054225904.1  calcitonin isoform X1

      UniProtKB/Swiss-Prot
      B7ZL39, P01258, Q13935, Q13937, Q52LX7