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    Atp11b ATPase, class VI, type 11B [ Mus musculus (house mouse) ]

    Gene ID: 76295, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Atp11bprovided by MGI
    Official Full Name
    ATPase, class VI, type 11Bprovided by MGI
    Primary source
    MGI:MGI:1923545
    See related
    Ensembl:ENSMUSG00000037400 AllianceGenome:MGI:1923545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ATPIF; ATPIR; mKIAA0956; 1110019I14Rik
    Summary
    Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in phospholipid translocation. Predicted to be located in early endosome membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in endoplasmic reticulum; plasma membrane; and recycling endosome. Is expressed in 2-cell stage embryo; 4-cell stage embryo; and dentate gyrus subgranular zone. Orthologous to human ATP11B (ATPase phospholipid transporting 11B (putative)). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 18.5), CNS E18 (RPKM 15.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atp11b in Genome Data Viewer
    Location:
    3 17.36 cM; 3 B
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (35808104..35910425)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (35754044..35856276)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6639 Neighboring gene STARR-seq mESC enhancer starr_07405 Neighboring gene STARR-seq mESC enhancer starr_07406 Neighboring gene STARR-seq mESC enhancer starr_07409 Neighboring gene STARR-positive B cell enhancer ABC_E9546 Neighboring gene predicted gene, 25696 Neighboring gene STARR-positive B cell enhancer ABC_E7907 Neighboring gene STARR-seq mESC enhancer starr_07413 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene chaperonin containing Tcp1, subunit 8 (theta) pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reanalysis of ATP11B, a type IV P-type ATPase. Halleck MS, et al. J Biol Chem, 2002 Mar 22. PMID 11790799
    2. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
    3. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phospholipid-translocating ATPase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid-transporting ATPase IF
    Names
    P4-ATPase flippase complex alpha subunit ATP11B
    probable phospholipid-transporting ATPase IF
    NP_083846.2
    XP_006535637.1
    XP_030108731.1
    XP_030108733.1
    XP_036019283.1
    XP_036019284.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029570.4 → NP_083846.2  phospholipid-transporting ATPase IF

      See identical proteins and their annotated locations for NP_083846.2

      Status: VALIDATED

      Source sequence(s)
      BC076603, CF952078, CJ128477, CN535194
      Consensus CDS
      CCDS38414.1
      UniProtKB/Swiss-Prot
      Q6DFW5
      UniProtKB/TrEMBL
      Q6ZQ17
      Related
      ENSMUSP00000029257.9, ENSMUST00000029257.15
      Conserved Domains (1) summary
      cd02073
      Location:41 → 978
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    RNA

    1. NR_151626.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157780, BC076603

    2. NR_151627.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157780, BC076603

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      35808104..35910425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163391.1 → XP_036019284.1  phospholipid-transporting ATPase IF isoform X4

      Conserved Domains (1) summary
      cl21460
      Location:13 → 590
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. XM_036163390.1 → XP_036019283.1  phospholipid-transporting ATPase IF isoform X1

      UniProtKB/TrEMBL
      Q6ZQ17
      Related
      ENSMUSP00000142676.2, ENSMUST00000198599.2
      Conserved Domains (1) summary
      cd02073
      Location:41 → 978
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    3. XM_006535574.4 → XP_006535637.1  phospholipid-transporting ATPase IF isoform X3

      UniProtKB/TrEMBL
      Q3U2B7
      Related
      ENSMUST00000200445.5
      Conserved Domains (1) summary
      cd02073
      Location:41 → 835
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    4. XM_030252871.1 → XP_030108731.1  phospholipid-transporting ATPase IF isoform X2

      UniProtKB/TrEMBL
      A0A0G2JE89
      Conserved Domains (2) summary
      cd02073
      Location:1 → 715
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      cl28910
      Location:654 → 800
      MFS; Major Facilitator Superfamily

    5. XM_030252873.1 → XP_030108733.1  phospholipid-transporting ATPase IF isoform X4

      Conserved Domains (1) summary
      cl21460
      Location:13 → 590
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DFW5.1 GenPept UniProtKB/Swiss-Prot:Q6DFW5

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