ClC-b Chloride channel-b [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ClC-bprovided by FlyBase
Official Full Name: Chloride channel-bprovided by FlyBase
Primary source: FLYBASE:FBgn0033755
Locus tag: Dmel_CG8594
See related: AllianceGenome:FB:FBgn0033755
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8594; clc-b; Clcn7; DmClC-b; DmClCb; Dmel\CG8594
Summary: Enables chloride transmembrane transporter activity. Involved in several processes, including chloride transmembrane transport; positive regulation of phagocytosis; and sensory perception of touch. Located in late endosome and phagolysosome. Is expressed in several structures, including adult head; embryonic/larval gut; embryonic/larval plasmatocyte; larval central nervous system; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in autosomal dominant osteopetrosis 2 and autosomal recessive osteopetrosis 4. Orthologous to human CLCN7 (chloride voltage-gated channel 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (12572068..12575299)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (8459573..8462804)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables chloride transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride:proton antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables chloride:proton antiporter activity	TAS Traceable Author Statement more info	PubMed
enables voltage-gated chloride channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloride transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in chloride transmembrane transport	TAS Traceable Author Statement more info	PubMed
involved_in chloride transport	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosomal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in phagolysosome	IDA Inferred from Direct Assay more info	PubMed
part_of transmembrane transporter complex	IPI Inferred from Physical Interaction more info	PubMed

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