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    GstO3 Glutathione S transferase O3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38972, updated on 17-Dec-2024

    Summary

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    Official Symbol
    GstO3provided by FlyBase
    Official Full Name
    Glutathione S transferase O3provided by FlyBase
    Primary source
    FLYBASE:FBgn0035904
    Locus tag
    Dmel_CG6776
    See related
    AllianceGenome:FB:FBgn0035904
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6776; Dmel\CG6776; DmGSTO3; GSTO3; T14
    Summary
    Enables glutathione dehydrogenase (ascorbate) activity and glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head; adult heart; embryonic midgut chamber; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Orthologous to human GSTO1 (glutathione S-transferase omega 1) and GSTO2 (glutathione S-transferase omega 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GstO3 in Genome Data Viewer
    Location:
    66D5-66D5; 3-26 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8518885..8520295)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8511985..8513395)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Pseudouridine synthase 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene sepia Neighboring gene Glutathione S transferase O2 Neighboring gene Glutathione S transferase O1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Therapeutic modulation of GSTO activity rescues FUS-associated neurotoxicity via deglutathionylation in ALS disease models. Cha SJ, et al. Dev Cell, 2022 Mar 28. PMID 35320731
    2. Canalization by Selection of de Novo Induced Mutations. Fanti L, et al. Genetics, 2017 Aug. PMID 28576865, Free PMC Article
    3. Glutathione s-transferase omega 1 activity is sufficient to suppress neurodegeneration in a Drosophila model of Parkinson disease. Kim K, et al. J Biol Chem, 2012 Feb 24. PMID 22219196, Free PMC Article
    4. Identification and characteristics of the structural gene for the Drosophila eye colour mutant sepia, encoding PDA synthase, a member of the omega class glutathione S-transferases. Kim J, et al. Biochem J, 2006 Sep 15. PMID 16712527, Free PMC Article
    5. Interaction of Omega, Sigma, and Theta glutathione transferases with p38b mitogen-activated protein kinase from the fruit fly, Drosophila melanogaster. Wongtrakul J, et al. J Insect Sci, 2014 May 1. PMID 25373207, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione dehydrogenase (ascorbate) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione dehydrogenase (ascorbate) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables pyrimidodiazepine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase O3
    Names
    CG6776-PA
    GstO3-PA
    glutathione transferase
    NP_648234.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8518885..8520295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139977.3 → NP_648234.1  glutathione S transferase O3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648234.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSL2
      Related
      FBpp0076348
      Conserved Domains (3) summary
      cd03184
      Location:109 → 230
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      COG0625
      Location:22 → 209
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cl00388
      Location:3 → 95
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSL2 Q9VSL2

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