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    CG10939 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44155, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10939provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010620
    Locus tag
    Dmel_CG10939
    See related
    AllianceGenome:FB:FBgn0010620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10939; l(2)06373; Sip1
    Summary
    Enables molecular adaptor activity. Involved in several processes, including epithelial structure maintenance; positive regulation of cell-cell adhesion; and regulation of renal system process. Is active in cytoplasmic side of apical plasma membrane. Is expressed in several structures, including adult head; anlage in statu nascendi; embryonic/larval midgut primordium; gut section; and head epidermis primordium. Used to study hypophosphatemic nephrolithiasis/osteoporosis 2. Human ortholog(s) of this gene implicated in hypophosphatemic nephrolithiasis/osteoporosis 2. Orthologous to human NHERF1 (NHERF family PDZ scaffold protein 1) and NHERF2 (NHERF family PDZ scaffold protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10939 in Genome Data Viewer
    Location:
    54B6-54B7; 2-82 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17394593..17405171)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13282098..13292676)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Alanine-TGC 1-1 Neighboring gene transfer RNA:Alanine-TGC 2-1 Neighboring gene Cathelicidin-like antimicrobial protein Neighboring gene Vajk4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of cell proliferation and adhesion by means of a novel region of drosophila merlin interacting with Sip1. Abeysundara N, et al. Dev Dyn, 2014 Dec. PMID 25204795
    2. The PP1 phosphatase flapwing regulates the activity of Merlin and Moesin in Drosophila. Yang Y, et al. Dev Biol, 2012 Jan 15. PMID 22133918
    3. Sip1, the Drosophila orthologue of EBP50/NHERF1, functions with the sterile 20 family kinase Slik to regulate Moesin activity. Hughes SC, et al. J Cell Sci, 2010 Apr 1. PMID 20215404, Free PMC Article
    4. Targeted renal knockdown of Na(+)/H(+) exchanger regulatory factor Sip1 produces uric acid nephrolithiasis in Drosophila. Ghimire S, et al. Am J Physiol Renal Physiol, 2019 Oct 1. PMID 31364377, Free PMC Article
    5. Molecular cloning of the Drosophila melanogaster gene alpha5_dm encoding a 20S proteasome alpha-type subunit. Zaiss D, et al. Gene, 1997 Nov 12. PMID 9409776

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sip1 facilitates the activation of Merlin as a tumor suppressor protein.
      Title: Regulation of cell proliferation and adhesion by means of a novel region of drosophila merlin interacting with Sip1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial structure maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cell-cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of renal system process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic side of apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10939-PA
    SRY interacting protein 1
    sex-determining region Y protein-interacting protein-1
    NP_524712.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17394593..17405171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079973.3 → NP_524712.1  uncharacterized protein Dmel_CG10939 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524712.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K5M6
      Related
      FBpp0086065
      Conserved Domains (1) summary
      cd00992
      Location:20 → 101
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K5M6 Q7K5M6

    Gene LinkOut

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