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    Hmgs HMG Coenzyme A synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44154, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hmgsprovided by FlyBase
    Official Full Name
    HMG Coenzyme A synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010611
    Locus tag
    Dmel_CG4311
    See related
    AllianceGenome:FB:FBgn0010611
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16796; CG4311; Dmel\CG4311; HMGS; l(2)06214; Ov25
    Summary
    Predicted to enable hydroxymethylglutaryl-CoA synthase activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Is expressed in several structures, including adult head; embryonic anal pad; embryonic head epidermis; epithelium; and gut section. Human ortholog(s) of this gene implicated in HMG-CoA synthase 2 deficiency. Orthologous to several human genes including HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hmgs in Genome Data Viewer
    Location:
    53C1-53C1; 2-80 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16336090..16341242)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12223595..12228747)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Vacuolar H[+] ATPase 44kD subunit Neighboring gene uncharacterized protein Neighboring gene Nucleoporin 62kD

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation. Silva B, et al. Nat Metab, 2022 Feb. PMID 35177854, Free PMC Article
    2. MicroRNA miR-8 promotes cell growth of corpus allatum and juvenile hormone biosynthesis independent of insulin/IGF signaling in Drosophila melanogaster. Zhang J, et al. Insect Biochem Mol Biol, 2021 Sep. PMID 34182107
    3. CoA protects against the deleterious effects of caloric overload in Drosophila. Palanker Musselman L, et al. J Lipid Res, 2016 Mar. PMID 26805007, Free PMC Article
    4. Modes of metabolic compensation during mitochondrial disease using the Drosophila model of ATP6 dysfunction. Celotto AM, et al. PLoS One, 2011. PMID 21991365, Free PMC Article
    5. Glial metabolism versatility regulates mushroom body-driven behavioral output in Drosophila. Basu R, et al. Learn Mem, 2024 May. PMID 38862167, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydroxymethylglutaryl-CoA synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxymethylglutaryl-CoA synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acetyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    HMG coenzyme A synthase
    Names
    CG4311-PA
    CG4311-PB
    CG4311-PC
    CG4311-PD
    CG4311-PE
    CG4311-PF
    HMG-CoA synthase
    Hmgs-PA
    Hmgs-PB
    Hmgs-PC
    Hmgs-PD
    Hmgs-PE
    Hmgs-PF
    hydroxy-3-methylglutaryl-CoA synthase
    NP_001286488.1
    NP_524711.1
    NP_725567.1
    NP_725568.1
    NP_725569.1
    NP_725570.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16336090..16341242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079972.4 → NP_524711.1  HMG coenzyme A synthase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524711.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4Q9
      Related
      FBpp0086289
      Conserved Domains (3) summary
      TIGR01833
      Location:5 → 456
      HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
      pfam08540
      Location:179 → 456
      HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal
      cl09938
      Location:8 → 178
      cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...

    2. NM_001299559.1 → NP_001286488.1  HMG coenzyme A synthase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286488.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4Q9
      Conserved Domains (3) summary
      TIGR01833
      Location:5 → 456
      HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
      pfam08540
      Location:179 → 456
      HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal
      cl09938
      Location:8 → 178
      cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...

    3. NM_166167.3 → NP_725568.1  HMG coenzyme A synthase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725568.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4Q9
      Related
      FBpp0086290
      Conserved Domains (3) summary
      TIGR01833
      Location:5 → 456
      HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
      pfam08540
      Location:179 → 456
      HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal
      cl09938
      Location:8 → 178
      cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...

    4. NM_166166.3 → NP_725567.1  HMG coenzyme A synthase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725567.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4Q9
      Related
      FBpp0086291
      Conserved Domains (3) summary
      TIGR01833
      Location:5 → 456
      HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
      pfam08540
      Location:179 → 456
      HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal
      cl09938
      Location:8 → 178
      cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...

    5. NM_166168.3 → NP_725569.1  HMG coenzyme A synthase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725569.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4Q9
      Related
      FBpp0086292
      Conserved Domains (3) summary
      TIGR01833
      Location:5 → 456
      HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
      pfam08540
      Location:179 → 456
      HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal
      cl09938
      Location:8 → 178
      cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...

    6. NM_166169.3 → NP_725570.1  HMG coenzyme A synthase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725570.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4Q9
      Related
      FBpp0086293
      Conserved Domains (3) summary
      TIGR01833
      Location:5 → 456
      HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
      pfam08540
      Location:179 → 456
      HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal
      cl09938
      Location:8 → 178
      cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K4Q9 Q7K4Q9

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