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    vav2 vav guanine nucleotide exchange factor 2 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 733982, updated on 4-Jan-2025

    Summary

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    Official Symbol
    vav2provided by Xenbase
    Official Full Name
    vav guanine nucleotide exchange factor 2provided by Xenbase
    Primary source
    Xenbase:XB-GENE-6067166
    See related
    Ensembl:ENSXETG00000019578 AllianceGenome:Xenbase:XB-GENE-6067166
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and metal ion binding activity. Predicted to act upstream of or within intracellular signal transduction. Orthologous to human VAV2 (vav guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See vav2 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 8 NC_030684.2 (8275449..8437508)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) Unplaced Scaffold NW_016683374.1 (254345..417129, complement)

    Chromosome 8 - NC_030684.2Genomic Context describing neighboring genes Neighboring gene bromodomain containing 3 Neighboring gene BRD3 opposite strand Neighboring gene nucleolin 1-like Neighboring gene NLR family CARD domain-containing protein 3 Neighboring gene beta-1,3-galactosyltransferase 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide exchange factor VAV2
    Names
    vav 2 guanine nucleotide exchange factor
    vav 2 oncogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045691.1 → NP_001039156.1  guanine nucleotide exchange factor VAV2

      See identical proteins and their annotated locations for NP_001039156.1

      Status: PROVISIONAL

      Source sequence(s)
      CR942591
      UniProtKB/TrEMBL
      A0A6I8RFJ2, Q28BX0
      Related
      ENSXETP00000080099.2, ENSXETT00000103455.2
      Conserved Domains (8) summary
      cd10406
      Location:650 → 752
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:779 → 836
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:580 → 639
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      cd01223
      Location:383 → 505
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00130
      Location:513 → 561
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00169
      Location:400 → 501
      PH; PH domain
      pfam00621
      Location:196 → 369
      RhoGEF; RhoGEF domain
      pfam11971
      Location:19 → 104
      CAMSAP_CH; CAMSAP CH domain

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      8275449..8437508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_031890516.1 → XP_031746376.1  guanine nucleotide exchange factor VAV2 isoform X1

      UniProtKB/TrEMBL
      A0A8J1IPD9, F6WZD6
      Conserved Domains (7) summary
      cd10406
      Location:699 → 801
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:855 → 912
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:629 → 688
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      cd01223
      Location:388 → 515
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00621
      Location:201 → 373
      RhoGEF; RhoGEF domain
      cd21263
      Location:3 → 121
      CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
      cd20868
      Location:518 → 575
      C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

    2. XM_031890518.1 → XP_031746378.1  guanine nucleotide exchange factor VAV2 isoform X3

      UniProtKB/TrEMBL
      A0A8J1ILM5, F6WZD6
      Conserved Domains (7) summary
      cd10406
      Location:694 → 796
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:850 → 907
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:624 → 683
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      cd01223
      Location:388 → 510
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00621
      Location:201 → 373
      RhoGEF; RhoGEF domain
      cd21263
      Location:3 → 121
      CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
      cd20868
      Location:513 → 570
      C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

    3. XM_031890520.1 → XP_031746380.1  guanine nucleotide exchange factor VAV2 isoform X5

      UniProtKB/TrEMBL
      A0A8J1INP5, F6WZD6
      Conserved Domains (7) summary
      cd10406
      Location:699 → 801
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:826 → 883
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:629 → 688
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      cd01223
      Location:388 → 515
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00621
      Location:201 → 373
      RhoGEF; RhoGEF domain
      cd21263
      Location:3 → 121
      CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
      cd20868
      Location:518 → 575
      C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

    4. XM_031890517.1 → XP_031746377.1  guanine nucleotide exchange factor VAV2 isoform X2

      UniProtKB/TrEMBL
      A0A8J1ILL5, F6WZD6
      Conserved Domains (7) summary
      cd10406
      Location:694 → 796
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:850 → 907
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:624 → 683
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      cd01223
      Location:383 → 510
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00621
      Location:196 → 368
      RhoGEF; RhoGEF domain
      cd21263
      Location:3 → 121
      CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
      cd20868
      Location:513 → 570
      C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

    5. XM_031890519.1 → XP_031746379.1  guanine nucleotide exchange factor VAV2 isoform X4

      UniProtKB/TrEMBL
      A0A8J1ILL8, F6WZD6
      Related
      ENSXETP00000042340.4, ENSXETT00000042340.4
      Conserved Domains (7) summary
      cd10406
      Location:689 → 791
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:845 → 902
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:619 → 678
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      cd01223
      Location:383 → 505
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00621
      Location:196 → 368
      RhoGEF; RhoGEF domain
      cd21263
      Location:3 → 121
      CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
      cd20868
      Location:508 → 565
      C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

    6. XM_012968560.3 → XP_012824014.1  guanine nucleotide exchange factor VAV2 isoform X6

      UniProtKB/TrEMBL
      A0A6I8RFJ2, A0A8J0SV09
      Related
      ENSXETP00000060789.2, ENSXETT00000062378.3
      Conserved Domains (8) summary
      cd10406
      Location:660 → 762
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:816 → 873
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:590 → 649
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      COG5261
      Location:36 → 179
      IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
      cd00160
      Location:198 → 373
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:388 → 515
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam11971
      Location:19 → 104
      CAMSAP_CH; CAMSAP CH domain
      pfam00130
      Location:523 → 571
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    7. XM_012968561.3 → XP_012824015.1  guanine nucleotide exchange factor VAV2 isoform X7

      UniProtKB/TrEMBL
      A0A6I8RFJ2, A0A8J0SWD0
      Conserved Domains (8) summary
      cd10406
      Location:660 → 762
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:787 → 844
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:590 → 649
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      cd01223
      Location:388 → 515
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00130
      Location:523 → 571
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00169
      Location:405 → 511
      PH; PH domain
      pfam00621
      Location:201 → 374
      RhoGEF; RhoGEF domain
      pfam11971
      Location:19 → 104
      CAMSAP_CH; CAMSAP CH domain

    RNA

    1. XR_004219473.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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