SGIP1 SH3GL interacting endocytic adaptor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SGIP1provided by HGNC
Official Full Name: SH3GL interacting endocytic adaptor 1provided by HGNC
Primary source: HGNC:HGNC:25412
See related: Ensembl:ENSG00000118473 MIM:611540; AllianceGenome:HGNC:25412
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: SGIP1 functions as an endocytic protein that affects signaling by receptors in neuronal systems involved in energy homeostasis via its interaction with endophilins (see SH3GL3; MIM 603362) (Trevaskis et al., 2005 [PubMed 15919751] and Uezu et al., 2007 [PubMed 17626015]).[supplied by OMIM, Mar 2008]
Expression: Biased expression in brain (RPKM 8.0), endometrium (RPKM 2.4) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p31.3

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (66533361..66751139)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (66410946..66628673)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (66999044..67216822)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plasma SGIP1 methylation in diagnosis and prognosis prediction in hepatocellular carcinoma.
Title: Plasma SGIP1 methylation in diagnosis and prognosis prediction in hepatocellular carcinoma.
Data indicate that cysteine C632 residue is important for the function of SH3 domain GRB2 like endophilin interacting protein 1 (SGIP1) during cellular endocytosis.
Title: SGIP1 dimerizes via intermolecular disulfide bond in μHD domain during cellular endocytosis.
The present study demonstrated a possible association of target P300 evoked theta and of alcohol dependence with SNPs from the gene SGIP1 in the region of rs10889635, but further studies are required.
Title: Event-related potentials (ERP) and SGIP1 gene polymorphisms in alcoholics: relation to family history of alcoholism and drug usage.
crystal structures of the SGIP1 mu homology domains in complex with peptides containing two DPF motifs, are reported.
Title: Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 μ homology domain.
Our results show association between genetic variants in SGIP1 and fat mass. We provide evidence that variation in SGIP1 is a potentially important determinant of obesity-related traits in humans
Title: Genetic variation in SH3-domain GRB2-like (endophilin)-interacting protein 1 has a major impact on fat mass.
The earlier implicated single nucleotide polymorphisms located in SGIP1 gene showed no association with alcohol dependence or theta electroencephalogram power.
Title: Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power.
SGIP1 and the signaling adaptor Reps1 interact with ITSN1 in vivo.
Title: Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide association identifies candidate genes that influence the human electroencephalogram.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene variants associated with ischemic stroke: the cardiovascular health study.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of early menopause and the combined impact of identified variants. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of antiphospholipid antibodies. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-30800 (e-PCR)
- UniSTS:74246

SHGC-131180 (e-PCR)
- UniSTS:167695

G54681 (e-PCR)
- UniSTS:117785

SHGC-79650 (e-PCR)
- UniSTS:101407

G16077 (e-PCR)
- UniSTS:58658

RH120417 (e-PCR)
- UniSTS:133412

D1S198 (e-PCR), detects polymorphism
- UniSTS:8484

AL033642 (e-PCR)
- UniSTS:93477

AL009520 (e-PCR)
- UniSTS:46897

RH119584 (e-PCR)
- UniSTS:132667

SHGC-58572 (e-PCR)
- UniSTS:94329

AL009405 (e-PCR)
- UniSTS:73855

G42182 (e-PCR)
- UniSTS:105100

D1S198 (e-PCR), detects polymorphism
- UniSTS:43703

G65675 (e-PCR)
- UniSTS:225467

D1S3585 (e-PCR)
- UniSTS:82655

G65597 (e-PCR)
- UniSTS:225531

Clone Names

FLJ33378, FLJ43054, DKFZp761D221, DKFZp686A16142

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables SH3 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipid binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in clathrin-dependent endocytosis	IEA Inferred from Electronic Annotation more info
involved_in energy homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of feeding behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of receptor-mediated endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to dietary excess	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle endocytosis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of AP-2 adaptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in clathrin-coated pit	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SH3-containing GRB2-like protein 3-interacting protein 1

Names: SH3 domain GRB2 like endophilin interacting protein 1; endophilin-3-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308203.2 → NP_001295132.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 2

See identical proteins and their annotated locations for NP_001295132.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which has the same N- and C-termini, but has some distinct internal segments, is lacking other internal segments, and is shorter than isoform 1.

Source sequence(s)

AL136561, AL354978, AW205180, BC040516, BX640813

Consensus CDS

CCDS76171.1

UniProtKB/TrEMBL

A0A804HJI3

Related

ENSP00000360078.1, ENST00000371039.5

Conserved Domains (1) summary

cd09266
Location:364 → 630

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001350217.2 → NP_001337146.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate in-frame exon in the 5' coding region, but also lacks an alternate exon in the 5' coding region, compared to variant 1. This variant encodes isoform 3, which has the same N- and C-termini, but is four aa longer than isoform 1.

Source sequence(s)

AB210039, AL136561, AL354978, AW205180, BC040516, DA491011

UniProtKB/TrEMBL

A0A804HJS7

Related

ENSP00000237247.6, ENST00000237247.10

Conserved Domains (1) summary

cd09266
Location:565 → 831

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001350218.2 → NP_001337147.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. This variant encodes isoform 4, which has the same N- and C-termini, but is shorter than isoform 1.

Source sequence(s)

AK299941, AL136561, AL354978, AW205180

UniProtKB/TrEMBL

B7Z5H8, B7Z691

Conserved Domains (1) summary

cd09266
Location:370 → 636

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376534.1 → NP_001363463.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

Consensus CDS

CCDS30744.1

UniProtKB/Swiss-Prot

A6NL81, A6NLD1, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2, Q9BQI5

UniProtKB/TrEMBL

A0A804HHZ7

Conserved Domains (1) summary

cd09266
Location:561 → 827

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376535.1 → NP_001363464.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

Consensus CDS

CCDS30744.1

UniProtKB/Swiss-Prot

A6NL81, A6NLD1, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2, Q9BQI5

UniProtKB/TrEMBL

A0A804HHZ7

Conserved Domains (1) summary

cd09266
Location:561 → 827

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376536.1 → NP_001363465.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

Consensus CDS

CCDS76171.1

UniProtKB/TrEMBL

A0A804HJI3

Related

ENSP00000508234.1, ENST00000684664.1

Conserved Domains (1) summary

cd09266
Location:364 → 630

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376537.1 → NP_001363466.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 5

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

UniProtKB/TrEMBL

A0A804HJJ5

Conserved Domains (1) summary

cd09266
Location:559 → 825

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376538.1 → NP_001363467.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 6

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

UniProtKB/TrEMBL

A0A804HJS7

Conserved Domains (1) summary

cd09266
Location:545 → 811

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376539.1 → NP_001363468.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 7

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

UniProtKB/TrEMBL

A0A804HHZ7

Conserved Domains (1) summary

cd09266
Location:541 → 807

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376540.1 → NP_001363469.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 7

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

UniProtKB/TrEMBL

A0A804HHZ7

Conserved Domains (1) summary

cd09266
Location:541 → 807

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376541.1 → NP_001363470.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 8

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

UniProtKB/TrEMBL

A0A804HJJ5

Conserved Domains (1) summary

cd09266
Location:537 → 803

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376542.1 → NP_001363471.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 8

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

UniProtKB/TrEMBL

A0A804HJJ5

Conserved Domains (1) summary

cd09266
Location:537 → 803

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376543.1 → NP_001363472.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 8

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

UniProtKB/TrEMBL

A0A804HJJ5

Conserved Domains (1) summary

cd09266
Location:537 → 803

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376544.1 → NP_001363473.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 9

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

UniProtKB/TrEMBL

A0A804HJJ5

Conserved Domains (1) summary

cd09266
Location:517 → 783

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376545.1 → NP_001363474.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 9

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

UniProtKB/TrEMBL

A0A804HJJ5

Conserved Domains (1) summary

cd09266
Location:517 → 783

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376546.1 → NP_001363475.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 10

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

UniProtKB/TrEMBL

B7Z5H8

Conserved Domains (1) summary

cd09266
Location:398 → 664

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376547.1 → NP_001363476.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 11

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

Consensus CDS

CCDS90969.1

UniProtKB/TrEMBL

A0A804HJG4, A0A804HJI3

Related

ENSP00000507495.1, ENST00000684168.1

Conserved Domains (1) summary

cd09266
Location:388 → 654

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376548.1 → NP_001363477.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 12

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

Consensus CDS

CCDS90970.1

UniProtKB/TrEMBL

A0A804HHV6, A0A804HJI3

Related

ENSP00000507159.1, ENST00000684178.1

Conserved Domains (1) summary

cd09266
Location:386 → 652

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376549.1 → NP_001363478.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 12

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

Consensus CDS

CCDS90970.1

UniProtKB/TrEMBL

A0A804HHV6, A0A804HJI3

Related

ENSP00000506779.1, ENST00000682707.1

Conserved Domains (1) summary

cd09266
Location:386 → 652

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376550.1 → NP_001363479.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 13

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

Consensus CDS

CCDS90971.1

UniProtKB/TrEMBL

A0A804HJI3, A0A804HJX5

Related

ENSP00000507684.1, ENST00000681971.1

Conserved Domains (1) summary

cd09266
Location:366 → 632

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376551.1 → NP_001363480.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 14

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

Consensus CDS

CCDS90972.1

UniProtKB/TrEMBL

B7Z5H8

Related

ENSP00000507311.1, ENST00000684539.1

Conserved Domains (1) summary

cd09266
Location:362 → 628

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376552.1 → NP_001363481.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 14

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

Consensus CDS

CCDS90972.1

UniProtKB/TrEMBL

B7Z5H8

Related

ENSP00000507967.1, ENST00000683257.1

Conserved Domains (1) summary

cd09266
Location:362 → 628

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376554.1 → NP_001363483.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 15

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

Consensus CDS

CCDS90973.1

UniProtKB/TrEMBL

A0A804HI01, B7Z5H8

Related

ENSP00000395525.3, ENST00000435165.3

Conserved Domains (1) summary

cd09266
Location:342 → 608

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376555.1 → NP_001363484.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 15

Status: VALIDATED

Source sequence(s)

AL139147, AL354978, AL356913

Consensus CDS

CCDS90973.1

UniProtKB/TrEMBL

A0A804HI01, B7Z5H8

Related

ENSP00000506836.1, ENST00000682293.1

Conserved Domains (1) summary

cd09266
Location:342 → 608

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
NM_001376556.1 → NP_001363485.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 16

Status: VALIDATED

Source sequence(s)

AL139147, AL356913

UniProtKB/TrEMBL

A0A804HIX4

Related

ENSP00000506802.1, ENST00000684083.1
NM_001376557.1 → NP_001363486.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 17

Status: VALIDATED

Source sequence(s)

AL139147, AL356913

UniProtKB/TrEMBL

A0A804HJ90

Related

ENSP00000410439.2, ENST00000424320.6
NM_032291.4 → NP_115667.2 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 1

See identical proteins and their annotated locations for NP_115667.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AL136561, AL354978, AW205180, BC040516, DA491011

Consensus CDS

CCDS30744.1

UniProtKB/Swiss-Prot

A6NL81, A6NLD1, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2, Q9BQI5

UniProtKB/TrEMBL

A0A804HHZ7

Related

ENSP00000360076.3, ENST00000371037.9

Conserved Domains (1) summary

cd09266
Location:561 → 827

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

66533361..66751139

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047432059.1 → XP_047288015.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X19

UniProtKB/TrEMBL

A0A804HJI3, A0A804HJX5
XM_047432054.1 → XP_047288010.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X13

UniProtKB/TrEMBL

A0A804HHV6, A0A804HJI3
XM_047432058.1 → XP_047288014.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X19

UniProtKB/TrEMBL

A0A804HJI3, A0A804HJX5
XM_005271270.5 → XP_005271327.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X21

See identical proteins and their annotated locations for XP_005271327.1

UniProtKB/TrEMBL

B7Z5H8

Conserved Domains (1) summary

cd09266
Location:362 → 628

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
XM_017002506.2 → XP_016857995.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1

UniProtKB/TrEMBL

A0A804HHZ7
XM_017002510.2 → XP_016857999.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X3

UniProtKB/TrEMBL

A0A804HHZ7
XM_017002524.2 → XP_016858013.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X8

UniProtKB/TrEMBL

A0A804HJI3

Conserved Domains (1) summary

cd09266
Location:408 → 674

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
XM_047432055.1 → XP_047288011.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X13

UniProtKB/TrEMBL

A0A804HHV6, A0A804HJI3
XM_017002508.2 → XP_016857997.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X2

UniProtKB/TrEMBL

A0A804HHZ7
XM_047432052.1 → XP_047288008.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X6

UniProtKB/TrEMBL

A0A804HHZ7

Related

ENSP00000506830.1, ENST00000683499.1
XM_047432051.1 → XP_047288007.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X5

UniProtKB/TrEMBL

A0A804HJJ5
XM_017002516.2 → XP_016858005.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X7

UniProtKB/TrEMBL

A0A804HJJ5

Related

ENSP00000508116.1, ENST00000682054.1

Conserved Domains (1) summary

cd09266
Location:551 → 817

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
XM_017002528.2 → XP_016858017.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X15

UniProtKB/TrEMBL

B7Z5H8
XM_047432061.1 → XP_047288017.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X22

UniProtKB/TrEMBL

A0A804HJ90

Related

ENSP00000507400.1, ENST00000683291.1
XM_006710961.3 → XP_006711024.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X4

See identical proteins and their annotated locations for XP_006711024.1

UniProtKB/TrEMBL

A0A804HJS7

Conserved Domains (1) summary

cd09266
Location:567 → 833

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
XM_006710971.3 → XP_006711034.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X9

See identical proteins and their annotated locations for XP_006711034.1

UniProtKB/TrEMBL

A0A804HJI3

Conserved Domains (1) summary

cd09266
Location:400 → 666

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
XM_017002529.2 → XP_016858018.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X16

UniProtKB/TrEMBL

A0A804HJI3
XM_006710973.3 → XP_006711036.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X11

See identical proteins and their annotated locations for XP_006711036.1

UniProtKB/TrEMBL

A0A804HJI3

Conserved Domains (1) summary

cd09266
Location:392 → 658

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
XM_047432053.1 → XP_047288009.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X12

UniProtKB/TrEMBL

B7Z5H8
XM_047432057.1 → XP_047288013.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X18

UniProtKB/TrEMBL

A0A804HJI3
XM_017002505.2 → XP_016857994.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1

UniProtKB/TrEMBL

A0A804HHZ7
XM_017002507.2 → XP_016857996.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X2

UniProtKB/TrEMBL

A0A804HHZ7
XM_011542291.2 → XP_011540593.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X10

See identical proteins and their annotated locations for XP_011540593.1

UniProtKB/TrEMBL

A0A804HJI3

Conserved Domains (1) summary

cd09266
Location:393 → 659

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
XM_011542292.2 → XP_011540594.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X17

See identical proteins and their annotated locations for XP_011540594.1

UniProtKB/TrEMBL

A0A804HJI3

Conserved Domains (1) summary

cd09266
Location:373 → 639

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins
XM_047432056.1 → XP_047288012.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X14

UniProtKB/TrEMBL

A0A804HJI3
XM_047432060.1 → XP_047288016.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X20

UniProtKB/TrEMBL

A0A804HJI3
XM_017002515.2 → XP_016858004.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X7

UniProtKB/TrEMBL

A0A804HJJ5

Related

ENSP00000507528.1, ENST00000683581.1

Conserved Domains (1) summary

cd09266
Location:551 → 817

SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

RNA

XR_007064415.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

66410946..66628673

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054339159.1 → XP_054195134.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X19

UniProtKB/TrEMBL

A0A804HJI3, A0A804HJX5
XM_054339152.1 → XP_054195127.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X13

UniProtKB/TrEMBL

A0A804HHV6, A0A804HJI3
XM_054339162.1 → XP_054195137.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X21

UniProtKB/TrEMBL

B7Z5H8
XM_054339138.1 → XP_054195113.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1

UniProtKB/TrEMBL

A0A804HHZ7
XM_054339141.1 → XP_054195116.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X3

UniProtKB/TrEMBL

A0A804HHZ7
XM_054339147.1 → XP_054195122.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X8

UniProtKB/TrEMBL

A0A804HJI3
XM_054339153.1 → XP_054195128.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X13

UniProtKB/TrEMBL

A0A804HHV6, A0A804HJI3
XM_054339140.1 → XP_054195115.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X2

UniProtKB/TrEMBL

A0A804HHZ7
XM_054339144.1 → XP_054195119.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X6

UniProtKB/TrEMBL

A0A804HHZ7
XM_054339143.1 → XP_054195118.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X5

UniProtKB/TrEMBL

A0A804HJJ5
XM_054339146.1 → XP_054195121.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X7

UniProtKB/TrEMBL

A0A804HJJ5
XM_054339155.1 → XP_054195130.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X15

UniProtKB/TrEMBL

B7Z5H8
XM_054339163.1 → XP_054195138.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X22

UniProtKB/TrEMBL

A0A804HJ90
XM_054339160.1 → XP_054195135.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X19

UniProtKB/TrEMBL

A0A804HJI3, A0A804HJX5
XM_054339142.1 → XP_054195117.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X4

UniProtKB/TrEMBL

A0A804HJS7
XM_054339148.1 → XP_054195123.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X9

UniProtKB/TrEMBL

A0A804HJI3
XM_054339156.1 → XP_054195131.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X16

UniProtKB/TrEMBL

A0A804HJI3
XM_054339150.1 → XP_054195125.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X11

UniProtKB/TrEMBL

A0A804HJI3
XM_054339151.1 → XP_054195126.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X12

UniProtKB/TrEMBL

B7Z5H8
XM_054339158.1 → XP_054195133.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X18

UniProtKB/TrEMBL

A0A804HJI3
XM_054339137.1 → XP_054195112.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1

UniProtKB/TrEMBL

A0A804HHZ7
XM_054339139.1 → XP_054195114.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X2

UniProtKB/TrEMBL

A0A804HHZ7
XM_054339149.1 → XP_054195124.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X10

UniProtKB/TrEMBL

A0A804HJI3
XM_054339157.1 → XP_054195132.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X17

UniProtKB/TrEMBL

A0A804HJI3
XM_054339154.1 → XP_054195129.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X14

UniProtKB/TrEMBL

A0A804HJI3
XM_054339161.1 → XP_054195136.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X20

UniProtKB/TrEMBL

A0A804HJI3
XM_054339145.1 → XP_054195120.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform X7

UniProtKB/TrEMBL

A0A804HJJ5