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    paics phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100488155, updated on 9-Dec-2024

    Summary

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    Official Symbol
    paicsprovided by Xenbase
    Official Full Name
    phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthaseprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-965995
    See related
    Ensembl:ENSXETG00000005615 AllianceGenome:Xenbase:XB-GENE-965995
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    ade2; airc; pais; paics.1
    Summary
    Predicted to enable ATP binding activity; carboxy-lyase activity; and phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Predicted to act upstream of or within 'de novo' IMP biosynthetic process. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See paics in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 1 NC_030677.2 (40866781..40892646)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 1 NC_030677.1 (31632332..31658195)

    Chromosome 1 - NC_030677.2Genomic Context describing neighboring genes Neighboring gene aminoadipate-semialdehyde dehydrogenase Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, gene 2 Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene LON peptidase N-terminal domain and ring finger 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    multifunctional protein ADE2; uncharacterized protein paics.1
    Names
    phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, gene 1
    phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030677.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      40866781..40892646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012955670.3 → XP_012811124.2  uncharacterized protein paics.1 isoform X1

      UniProtKB/TrEMBL
      A0A803JC09
      Related
      ENSXETP00000105398.1, ENSXETT00000112681.1
      Conserved Domains (3) summary
      cd01416
      Location:610 → 861
      SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
      TIGR01162
      Location:871 → 1024
      purE; phosphoribosylaminoimidazole carboxylase, PurE protein
      pfam13837
      Location:152 → 235
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    2. XM_012955671.3 → XP_012811125.2  uncharacterized protein paics.1 isoform X2

      UniProtKB/TrEMBL
      A0A8J0SCV8
      Conserved Domains (3) summary
      cd01416
      Location:609 → 860
      SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
      TIGR01162
      Location:870 → 1023
      purE; phosphoribosylaminoimidazole carboxylase, PurE protein
      pfam13837
      Location:152 → 235
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    3. XM_031895412.1 → XP_031751272.1  uncharacterized protein paics.1 isoform X3

      UniProtKB/TrEMBL
      A0A8J1J096
      Conserved Domains (3) summary
      cd01416
      Location:585 → 836
      SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
      TIGR01162
      Location:846 → 999
      purE; phosphoribosylaminoimidazole carboxylase, PurE protein
      pfam13837
      Location:152 → 235
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    4. XM_012955673.3 → XP_012811127.2  uncharacterized protein paics.1 isoform X4

      UniProtKB/TrEMBL
      A0A6I8SSC3
      Related
      ENSXETP00000096021.2, ENSXETT00000080143.2
      Conserved Domains (3) summary
      cd01416
      Location:475 → 726
      SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
      TIGR01162
      Location:736 → 889
      purE; phosphoribosylaminoimidazole carboxylase, PurE protein
      pfam13837
      Location:152 → 235
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    5. XM_004911198.4 → XP_004911255.1  multifunctional protein ADE2 isoform X5

      See identical proteins and their annotated locations for XP_004911255.1

      UniProtKB/TrEMBL
      A0A803JV91, A0A8J0R0U7
      Related
      ENSXETP00000012371.3, ENSXETT00000012371.3
      Conserved Domains (2) summary
      cd01416
      Location:7 → 258
      SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
      TIGR01162
      Location:268 → 421
      purE; phosphoribosylaminoimidazole carboxylase, PurE protein

    6. XM_012955674.3 → XP_012811128.1  multifunctional protein ADE2 isoform X5

      See identical proteins and their annotated locations for XP_012811128.1

      UniProtKB/TrEMBL
      A0A803JV91, A0A8J0R0U7
      Conserved Domains (2) summary
      cd01416
      Location:7 → 258
      SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
      TIGR01162
      Location:268 → 421
      purE; phosphoribosylaminoimidazole carboxylase, PurE protein

    7. XM_002934673.5 → XP_002934719.2  multifunctional protein ADE2 isoform X5

      See identical proteins and their annotated locations for XP_002934719.2

      UniProtKB/TrEMBL
      A0A803JV91, A0A8J0R0U7
      Related
      ENSXETP00000111953.1, ENSXETT00000105303.1
      Conserved Domains (2) summary
      cd01416
      Location:7 → 258
      SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
      TIGR01162
      Location:268 → 421
      purE; phosphoribosylaminoimidazole carboxylase, PurE protein
    Nucleotide Protein Strain
    Heading Accession and Version

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