fgfr3 fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: fgfr3provided by Xenbase
Official Full Name: fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)provided by Xenbase
Primary source: Xenbase:XB-GENE-479255
See related: Ensembl:ENSXETG00000002396 AllianceGenome:Xenbase:XB-GENE-479255
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: ach; cek2; jtk4; cd333; fgfr-3; hsfgfr3ex
Summary: Predicted to enable ATP binding activity and fibroblast growth factor receptor activity. Acts upstream of or within embryonic body morphogenesis. Predicted to be located in plasma membrane. Is expressed in anatomical system; ectoderm; and mesenchyme. Human ortholog(s) of this gene implicated in several diseases, including Human papillomavirus infectious disease; SADDAN; acanthosis nigricans; bone disease (multiple); and carcinoma (multiple). Orthologous to human FGFR3 (fibroblast growth factor receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	1	NC_030677.2 (20843644..20911445)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	1	NC_030677.1 (12769288..12836770, complement)

Chromosome 1 - NC_030677.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroblast growth factor receptor 3

NP_001135467.1

EC 2.7.10.1

XP_012812743.1

EC 2.7.10.1

XP_012812749.1

EC 2.7.10.1

XP_012812753.1

EC 2.7.10.1

XP_012812760.1

EC 2.7.10.1

XP_031752005.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001141995.1 → NP_001135467.1 fibroblast growth factor receptor 3

See identical proteins and their annotated locations for NP_001135467.1

Status: PROVISIONAL

Source sequence(s)

BC168038

UniProtKB/TrEMBL

A0A6I8RGC9, B4F6W5

Related

ENSXETP00000080689.2, ENSXETT00000086796.2

Conserved Domains (4) summary

cd05857
Location:177 → 261

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:284 → 373

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

cd05100
Location:474 → 807

PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

smart00408
Location:74 → 129

IGc2; Immunoglobulin C-2 Type

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030677.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

20843644..20911445

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_012957289.3 → XP_012812743.1 fibroblast growth factor receptor 3 isoform X5

UniProtKB/TrEMBL

A0A6I8RGC9, A0A8J0SG86

Conserved Domains (4) summary

cd05857
Location:177 → 261

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05100
Location:476 → 809

PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

smart00408
Location:74 → 129

IGc2; Immunoglobulin C-2 Type

cd04974
Location:284 → 371

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
XM_012957306.3 → XP_012812760.1 fibroblast growth factor receptor 3 isoform X2

UniProtKB/TrEMBL

A0A6I8RGC9, A0A6I8SYT7, F6V1T7

Related

ENSXETP00000005103.3, ENSXETT00000005103.4

Conserved Domains (4) summary

cd05857
Location:177 → 261

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05100
Location:475 → 808

PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

smart00408
Location:74 → 129

IGc2; Immunoglobulin C-2 Type

cd04974
Location:284 → 371

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
XM_012957299.3 → XP_012812753.1 fibroblast growth factor receptor 3 isoform X3

UniProtKB/TrEMBL

A0A6I8RGC9, A0A6I8RGZ1

Related

ENSXETP00000080879.2, ENSXETT00000103276.2

Conserved Domains (7) summary

cd04974
Location:284 → 371

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:177 → 261

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05100
Location:475 → 808

PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

smart00408
Location:74 → 129

IGc2; Immunoglobulin C-2 Type

smart00409
Location:75 → 145

IG; Immunoglobulin

smart00410
Location:276 → 370

IG_like; Immunoglobulin like

pfam07714
Location:488 → 764

Pkinase_Tyr; Protein tyrosine kinase
XM_031896145.1 → XP_031752005.1 fibroblast growth factor receptor 3 isoform X4

UniProtKB/TrEMBL

A0A6I8RGC9, A0A8J1J4S6

Conserved Domains (5) summary

cd05100
Location:474 → 807

PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

smart00408
Location:74 → 129

IGc2; Immunoglobulin C-2 Type

cd00096
Location:269 → 272

Ig; Ig strand A [structural motif]

cd05857
Location:167 → 261

IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains

cl11960
Location:269 → 373

Ig; Immunoglobulin domain
XM_012957295.3 → XP_012812749.1 fibroblast growth factor receptor 3 isoform X1

UniProtKB/TrEMBL

A0A6I8RGC9, A0A6I8SPF3

Related

ENSXETP00000099567.2, ENSXETT00000070721.2

Conserved Domains (4) summary

cd05857
Location:177 → 261

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:284 → 373

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

cd05100
Location:475 → 808

PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

smart00408
Location:74 → 129

IGc2; Immunoglobulin C-2 Type